Recent pharmaceutical applications of raman and terahertz spectroscopies

McGoverin, Cushla; Rades, Thomas; Gordon, Keith C.

doi:10.1002/jps.21340

Cited by 79 publications

(44 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Raman spectroscopy is more suitable for the in vivo or in situ study of aqueous samples, as water has weak Raman scattering properties (Li-Chan, 1996). Raman spectroscopy is based on the inelastic scattering of photons (from a laser) upon interaction with sample molecules (McGoverin, Rades, & Gordon, 2008). Raman spectroscopy allows one to obtain information about the properties and the structure of molecules from their stretching and bending vibrational transitions (Nafie, 2001).…”

Section: Introductionmentioning

confidence: 99%

Composition of bovine milk fat globules by confocal Raman microscopy

Gallier

Gordon

Jiménez-Flores

et al. 2011

International Dairy Journal

Self Cite

105

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Composition of bovine milk fat globules by confocal Raman microscopy

Gallier

Gordon

Jiménez-Flores

et al. 2011

International Dairy Journal

Self Cite

105

View full text Add to dashboard Cite

“…This has been pioneered for absorption methods using terahertz spectroscopy [23,24]. Transitions in the low wavenumber (10-200 cm À1 ) region, sometimes called the terahertz region, can originate from the phonon lattice modes of the crystalline structure [25].…”

Section: Introductionmentioning

confidence: 99%

Use of low-frequency Raman spectroscopy and chemometrics for the quantification of crystallinity in amorphous griseofulvin tablets

Mah

Fraser

Reish

et al. 2015

Vibrational Spectroscopy

Self Cite

View full text Add to dashboard Cite

“…Several reviews have been published describing the general mechanisms of action of process analytical tools in pharmaceutical production processes. Readers are referred to these publications illustrating near infrared (NIR) spectroscopy, [35][36][37][38][39][40][41] Raman spectroscopy, [35,38,39,[42][43][44][45] ultraviolet/ visible (UV-VIS) spectroscopy, [35] fluorescence spectroscopy, [35] terahertz (THz) spectroscopy, [35,39,42,46,47] nuclear magnetic resonance (NMR) spectroscopy, [35] ultrasound techniques [48] and rheological techniques. [49,50] Process analytical tools for hot-melt extrusion…”

Section: Hot-melt Extrusionmentioning

confidence: 99%

Process monitoring and visualization solutions for hot-melt extrusion: a review

Saerens

Vervaet

Remon

et al. 2013

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives Hot-melt extrusion (HME) is applied as a continuous pharmaceutical manufacturing process for the production of a variety of dosage forms and formulations. To ensure the continuity of this process, the quality of the extrudates must be assessed continuously during manufacturing. The objective of this review is to provide an overview and evaluation of the available process analytical techniques which can be applied in hot-melt extrusion. Key Findings Pharmaceutical extruders are equipped with traditional (univariate) process monitoring tools, observing barrel and die temperatures, throughput, screw speed, torque, drive amperage, melt pressure and melt temperature. The relevance of several spectroscopic process analytical techniques for monitoring and control of pharmaceutical HME has been explored recently. Nevertheless, many other sensors visualizing HME and measuring diverse critical product and process parameters with potential use in pharmaceutical extrusion are available, and were thoroughly studied in polymer extrusion. The implementation of process analytical tools in HME serves two purposes: (1) improving process understanding by monitoring and visualizing the material behaviour and (2) monitoring and analysing critical product and process parameters for process control, allowing to maintain a desired process state and guaranteeing the quality of the end product. Summary This review is the first to provide an evaluation of the process analytical tools applied for pharmaceutical HME monitoring and control, and discusses techniques that have been used in polymer extrusion having potential for monitoring and control of pharmaceutical HME.

show abstract

Recent pharmaceutical applications of raman and terahertz spectroscopies

Cited by 79 publications

References 108 publications

Composition of bovine milk fat globules by confocal Raman microscopy

Composition of bovine milk fat globules by confocal Raman microscopy

Use of low-frequency Raman spectroscopy and chemometrics for the quantification of crystallinity in amorphous griseofulvin tablets

Process monitoring and visualization solutions for hot-melt extrusion: a review

Contact Info

Product

Resources

About