Recent parvovirus B19 infection in late pregnancy

Žegarac, Žana; Duić, Željko; Borovečki, Ana

doi:10.1016/j.ijgo.2013.04.006

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…This was in a cohort of 96 pregnancies diagnosed with acute maternal B19V infection between 21 and 24 weeks 26 . B19V has been detected in stillbirths up to 41 weeks gestation 3,7,59‐61 . In a case series of stillbirths born after 22 weeks, parvovirus was detected in 13 of the 92 (14%) cases 62 .…”

Section: Pregnancy Outcomesmentioning

confidence: 95%

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Identification and management of congenital parvovirus B19 infection

2020

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Parvovirus B19 (B19V) infection is well known for its mild, self-limiting clinical presentations in children, such as erythema infectiosum. Approximately 40% of women of childbearing age are susceptible to B19V infection. While maternal B19V infection usually has a good prognosis, B19V can cause severe fetal anaemia and pregnancy loss due to its ability to suppress erythroid progenitor cells. Non-invasive ultrasound monitoring for fetal anaemia is usually performed if maternal seroconversion occurs in the first 20 weeks of gestation, with amniocentesis for fetal infection reserved for those who first present with fetal anaemia or hydrops of unknown cause. Intrauterine transfusion is the standard treatment for severe fetal anaemia and is associated with a significant improvement in survival. However, survivors of hydrops fetalis may have a higher rate of long-term neurodevelopmental complications compared with non-hydropic survivors. This review aims to synthesise published data on the diagnosis, surveillance and outcomes of congenital parvovirus infection to assist clinicians in diagnosing and managing this important condition.

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Section: Pregnancy Outcomesmentioning

confidence: 95%

“…26 B19V has been detected in stillbirths up to 41 weeks gestation. 3,7,[59][60][61] In a case series of stillbirths born after 22 weeks, parvovirus was detected in 13 of the 92 (14%) cases. 62 Only two of the parvovirus B19 DNA-positive cases were hydropic.…”

Section: Management Of Anaemia and Nihfmentioning

confidence: 99%

Identification and management of congenital parvovirus B19 infection

2020

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“…Nuo 20 savaitės vaisiaus imuninė sistema produkuoja nedidelius kiekius IgM klasės antikūnų. Papildomai antikūnų motina perduoda per placentą [58,67].…”

Section: Rezultataiunclassified

“…Europoje apie 1,2 milijono moterų per metus gali būti infekuotos. Vai-sių praranda 0,2 proc., taigi, apie 3000 kūdikių [17,67].…”

Section: Rezultataiunclassified

Parvovirusas b19: struktūra, patogenezė, epidemiologija, organizmo imuninis atsakas

2014

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SantraukaParvovirusas B19 yra vienas mažiausių žinomų DNR genomą turinčių virusų, kurie gali infekuoti žinduolių ląsteles. Šis virusas paplitęs visame pasaulyje. Jis plinta lašeliniu būdu bei per donorų kraują. Parvoviruso B19 infekcija dažniausiai persergama vaikystėje ir daugelis suaugusiųjų jau turi IgG antikūnus prieš parvovirusą B19. Parvoviruso B19 infekcija sukelia neženklius pažeidimus, neretai infekcijos metu nėra jokios klinikinės raiškos. Vaikams parvovirusas B19 sukelia infekcinę eritemą, o suaugusiems gali sukelti artralgijas ir artropatijas. Parvovirusas pavojingas asmenims, kuriems yra imuniniai ir hematologiniai sutrikimai, dėl parvoviruso B19 jiems gali atsirasti sunki anemija. Taip pat virusas pavojingas nėščioms moterims, nes sukelia vaisiaus pažeidimus, vaisiaus vandenligę, netgi persileidimus. Parvoviruso B19 infekcija dažniau būna sergant tam tikromis ligomis (reumatoidiniu artritu, raudonąja vilklige, esant lėtinio nuovargio sindromui, kardiopatijai). Kaip virusas veikia šių ligų patogenezėje iki šiol nėra žinoma. Šiame straipsnyje apibendrinami naujausi mokslinės literatūros duomenys apie parvoviruso B19 struktūrą, patogenezę, epidemiologiją, organizmo imuninį atsaką bei infekcijos nustatymo metodus. ĮvadasParvovirusai -vieni mažiausių DNR genomą turinčių virusų. Virusų šeimos Parvoviridae pavadinimas kilęs iš lotyniško žodžio "parvum", reiškiančio "mažas" [1,2]. Parvovirusai gyvūnų pasaulyje plačiai paplitę, jie infekuoja stuburinius, vabzdžius ir vėžiagyvius. Mokslo bendruomenė daugiausia dėmesio skiria patologiniams žinduolių parvovirusams: šunis, kates, kiaules ir ypač žmones infekuojantiems parvovirusams. Žinomi 4 žmones infekuojan-

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Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays

et al. 2019

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SUMMARY Infections during pregnancy that may cause congenital abnormalities have been recognized for decades, but their diagnosis is challenging. This was again illustrated with the emergence of Zika virus (ZIKV), highlighting the inherent difficulties in estimating the extent of pre- and postnatal ZIKV complications because of the difficulties in establishing definitive diagnoses. We reviewed the epidemiology, infection kinetics, and diagnostic methods used for Toxoplasma gondii, parvovirus B19, rubella virus, and cytomegalovirus (TORCH) infections and compared the results with current knowledge of ZIKV diagnostic assays to provide a basis for the inclusion of ZIKV in the TORCH complex evaluations. Similarities between TORCH pathogens and ZIKV support inclusion of ZIKV as an emerging TORCH infection. Our review evaluates the diagnostic performance of various TORCH diagnostic assays for maternal screening, fetal screening, and neonatal screening. We show that the sensitivity, specificity, and positive and negative predictive value of TORCH complex pathogens are widely variable, stressing the importance of confirmatory testing and the need for novel techniques for earlier and accurate diagnosis of maternal and congenital infections. In this context it is also important to acknowledge different needs and access to care for different geographic and resource settings.

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Recent parvovirus B19 infection in late pregnancy

Cited by 3 publications

References 5 publications

Identification and management of congenital parvovirus B19 infection

Identification and management of congenital parvovirus B19 infection

Parvovirusas b19: struktūra, patogenezė, epidemiologija, organizmo imuninis atsakas

Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays

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