Recent-onset rheumatoid arthritis: a 1-year observational study of correlations between health-related quality of life and clinical/laboratory data

Thyberg, Ingrid; Hass, Ursula; Gerdle, Björn

doi:10.1080/16501970410023344

Cited by 18 publications

(18 citation statements)

References 21 publications

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“…Grip force and walking speed from inclusion through 1-year followup in the Swedish TIRA cohort were also found to be significant regressors of self-reported variables (36). Compared with a healthy Swedish reference population (21), the grip force reduction in patients with RA with a disease duration of 12 years was ϳ75% in women.…”

mentioning

confidence: 84%

Activity limitation in rheumatoid arthritis correlates with reduced grip force regardless of sex: The Swedish TIRA project

Thyberg¹,

Hass²,

Nordenskiöld³

et al. 2005

Arthritis & Rheumatism

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Objective. To evaluate activity limitations 3 years after diagnosis of early rheumatoid arthritis (RA) in relation to grip force and sex. Methods. A total of 217 patients, 153 women and 64 men, with recent-onset RA were included. Activity limitations were reported using the Health Assessment Questionnaire (HAQ) and the Evaluation of Daily Activities Questionnaire (EDAQ). The relationships between activity limitations versus grip force (measured by the Grippit), walking speed, functional impairment, grip ability, pain, plasma C-reactive protein, the 28-joint disease activity score and its components, the physician's global assessment of disease activity, and sex were analyzed by partial least squares (PLS). Results. Women had significantly lower grip force and more activity limitations (HAQ and EDAQ) than men. The PLS analyses demonstrated that grip force was the strongest regressor of activity limitation, closely followed by walking speed. However, within subgroups based on grip force (group 1 ‫؍‬ grip force <114 N, group 2 ‫؍‬ 116 -206 N, group 3 ‫؍‬ 214 -321 N, group 4 ‫؍‬ grip force >328 N) and including sexes, women and men had corresponding degrees of activity limitation as reported by the HAQ and EDAQ. Conclusion. Our results indicate that the more pronounced activity limitations seen in women with RA, as compared with men, may be explained by lower grip force rather than sex.

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mentioning

confidence: 84%

Activity limitation in rheumatoid arthritis correlates with reduced grip force regardless of sex: The Swedish TIRA project

Thyberg¹,

Hass²,

Nordenskiöld³

et al. 2005

Arthritis & Rheumatism

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“…The Swedish TIRA project This study was conducted in association with the Swedish multi-centre early intervention project TIRA [1,3,5,16,18,33]. In total, 320 patients with recent-onset (≤1 year) RA who fulfilled ≥4 of 7 RA classification criteria or at least morning stiffness ≥60 min, symmetrical arthritis and arthritis of small joints were included in the TIRA cohort during 1996-1998.…”

Section: Methodsmentioning

confidence: 99%

“…At year 8, the TIRA cohort had only a slightly better mean HAQ score in comparison with patients with a mean of 14 years of RA registered in southern Sweden in 2005 [47]. A general aim of the TIRA project was to establish routines for early diagnosis and early instituted DMARD [1,13,47]. This was still a rather new concept, and only 42% of patients were prescribed DMARD at inclusion.…”

Section: Vitality Social Functioningmentioning

confidence: 96%

“…Rheumatoid arthritis (RA) is a chronic inflammatory disease that often contributes to physical as well as psychosocial disabilities soon after diagnosis [1][2][3][4][5][6][7][8]. The today's strategy with early instituted disease-modifying antirheumatic drugs (DMARD) reduces disease activity and improves disability [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Potential of the HAQ score as clinical indicator suggesting comprehensive multidisciplinary assessments: the Swedish TIRA cohort 8 years after diagnosis of RA

et al. 2012

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This study explores the potential of the health assessment questionnaire (HAQ) score as a clinical indicator that can be used to suggest comprehensive multidisciplinary assessments, by relating it to more general aspects of disability. In a cohort of 132 patients with early RA (mean age 55, 68% women), 28 joint count Disease Activity Scores (DAS-28), HAQ, and Short Form 36 (SF-36) scores were registered at annual follow-up visits 8 years after diagnosis. The patients were tentatively sub-grouped into a high-HAQ group (HAQ ≥ 1 at the 8-year follow-up) and a low-HAQ group. The high-HAQ group, comprising 36% of the cohort, had a higher mean HAQ score at inclusion and beyond at all visits compared to the low-HAQ group, and 24% of all individual patients in the high-HAQ group had a HAQ score ≥ 1 at inclusion. Although the DAS-28 improved in both groups, patients in the high-HAQ group also had significantly more persistent disability according to the SF-36: five scales at each follow-up visit and all eight scales at the majority of the visits. Individual RA patients with HAQ ≥ 1 probably have considerable persistent disabilities according to the SF-36. The HAQ score could be used as a clinical indicator suggesting comprehensive multidisciplinary assessments of the components of disability and corresponding interventions, in addition to the established use of HAQ at group levels and in parallel with the medication strategy based on DAS-28.

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“…4 Most observers recognize that biomedical measures such as clinical or laboratory indices do not provide a complete representation of the effect of a treatment on an individual. 5 These measures, while important in their own right, are being supplemented by measures of constructs that focus on issues of importance to the patient such as functional status, health-related quality of life and emotional well being. 6 Compared with concrete measures like blood pressure, constructs such as pain relief, walking ability or depression are complex to measure.…”

Section: Introductionmentioning

confidence: 99%

Payment by Results or Payment by Outcome? The History of Measuring Medicine

O’Connor

Neumann

2006

J R Soc Med

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Recent-onset rheumatoid arthritis: a 1-year observational study of correlations between health-related quality of life and clinical/laboratory data

Cited by 18 publications

References 21 publications

Activity limitation in rheumatoid arthritis correlates with reduced grip force regardless of sex: The Swedish TIRA project

Activity limitation in rheumatoid arthritis correlates with reduced grip force regardless of sex: The Swedish TIRA project

Potential of the HAQ score as clinical indicator suggesting comprehensive multidisciplinary assessments: the Swedish TIRA cohort 8 years after diagnosis of RA

Payment by Results or Payment by Outcome? The History of Measuring Medicine

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