Recent Nanocochleate Drug Delivery System for Cancer Treatment: A Review

Nayek, Sujit; Venkatachalam, Abhirami; Choudhury, Sangeeta

doi:10.22159/ijcpr.2019v11i6.36359

Cited by 7 publications

(2 citation statements)

References 13 publications

(19 reference statements)

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“…The addition of a calcium cation to the bathing buffer makes sure that the cochleate structures are intact throughout the washing step and continue to remain as precipitates 19,27 .…”

Section: Methods Of Preparationmentioning

confidence: 99%

Untitled

2021

IJPSR

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Nanocochleate is a novel lipid-based drug delivery system in which the liposomal vesicles are converted into nanocochleate by the addition of Calcium divalent cation. This technology involves encochleation of the drug for overcoming problems such as poor solubility, poor permeability, and poor oral bioavailability. This novel lipid-based formulation approach is applicable for the category of drugs like BCS class III drugs, BCS class IV drugs. Applications of this technology can also be extended to macromolecules as well as small molecule drugs that are lipophilic with poor oral bioavailability. It is appropriate for oral as well as systemic administration of biologically active molecules, including drugs, genes, proteins, peptides, and vaccine antigens. This article covers multiple aspects of Nanocochleate drug delivery system, such as its definition, composition, method of preparation, and mechanism of permeation. The article also elaborates on various advantages, disadvantages, and applications of Nanocochleate drug delivery system. The article highlights the potential of this novel system for oral as well as systemic delivery of chemical and biological drug products. INTRODUCTION:Successful delivery of biological molecule-based pharmaceutical products is primarily determined by its ability to cross the various barriers in the human body. Various barriers encountered by the delivery system include enzymatic barriers, intestinal epithelial barriers, capillary endothelial barriers, blood-brain barrier (BBB) 1 . The Oral route is the most common and acceptable route for drug delivery due to advantages such as high patient compliance, non-invasiveness, convenience, and acceptability. However, it is challenging to deliver biological molecules like protein and peptides, vaccines, genes, etc. by oral route due to reasons such as:

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“…The addition of a calcium cation to the bathing buffer makes sure that the cochleate structures are intact throughout the washing step and continue to remain as precipitates 19,27 .…”

Section: Methods Of Preparationmentioning

confidence: 99%

Untitled

2021

IJPSR

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“…In the paper, authors exemplified the various methods to prepare Nanocochleates and mechanisms of drug delivery. In the end, author/s recommended that in the treatment of cancer cells, application of Nanocochleate can progress the effectiveness of chemotherapeutic agents and this novel drug delivery system can push the therapeutic world into the renewed era [118].…”

Section: Fig 10: Preparation Of Phospholipid Vesicle For the Delivermentioning

confidence: 99%

Curcumin, a Natural Golden Drug and Its Anticancer Aspects From Synthesis to Delivery: A Review

2020

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Cancer is a dreadful disease and, in most cases, leads to death even when it is being treated. Even though synthetic drugs are still in use for the treatment of cancer, the seriousness of the side effects of these drugs has boggled researcher’s mind to find more effective drugs which will help to overcome the side effects and have greater potency in trying to make the patient completely free of the disease. Recently, researchers turned their attention towards bio-components present in natural products. Curcumin, a polyphenol and the main constituent of a rhizome Curcuma longa, has geared significant interest due to its wide spectrum of therapeutics values, especially anticancer activity. Paper summarizes the chemistry and bio-metabolism of curcumin in the human body. Aim of this review article is to gather the dispersed efforts of researchers predominantly in improving the bioavailability of curcumin. In the present review, comprehensive literature on anticancer activity of Curcumin via combination therapy, structure modification, synthesis of analogues, novel delivery systems have been highlighted. Besides, the review paper explicated several challenges associated with Curcumin as an adjuvant chemotherapeutic agent and emphasizes more on clinical studies.

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