Recent Korean isolates of duck hepatitis virus reveal the presence of a new geno- and serotype when compared to duck hepatitis virus type 1 type strains

Kim, M.-C.; Kwon, Yong-Kuk; Joh, Seong-Joon; Kim, S.-J.; Tolf, C.; Kim, J.-H.; Sung, H.-W.; Lindberg, A. M.; Kwon, Jun-Hun

doi:10.1007/s00705-007-1104-0

Cited by 9 publications

(19 citation statements)

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“…Based on phylogenetic analyses and neutralization tests, DHAVs are classified into three genotypes: DHAV-1, DHAV-2, and DHAV-3. There is no cross-neutralization between genotypes [5,6]. According to previous studies, DHAV-1 is widely distributed in China [7][8][9], DHAV-3 has been reported in Korea and China [5], whereas DHAV-2 has been detected only in Taiwan [6].…”

Section: Introductionmentioning

confidence: 89%

Molecular genotyping of duck hepatitis A viruses (DHAV) in Vietnam

Doan

Thi

et al. 2016

J Infect Dev Ctries

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Introduction: The aim of this study was to identify the genetic characteristics and molecular genotyping of duck hepatitis A virus (DHAV) isolated in Vietnam during [2009][2010][2011][2012][2013]. Methodology: Thirty duckling livers from outbreaks between 2009 and 2013 in seven provinces were collected and identified by polymerase chain reaction (PCR). Then, VP1 genes of eleven positive samples and two attenuated vaccine strains were sequenced and analyzed. Results: Genotypic and phylogenetic analyses indicated that the 13 Vietnamese isolates were classified into two genotypes, DHAV-1 and DHAV-3. The rate of identity and homology was 91%-100% between the 10 Vietnamese and 26 global strains of DHAV-3, and 92%-100% between 3 Vietnamese and 16 strains of DHAV-1. Between the DHAV-3 and DHAV-1 strains, the divergence reached 30%. At the C-terminal of VP1 for the different strains, a hypervariable region was observed, and notably, six of the Vietnamese DHAV-3 strains in this study showed four consistent differences (at positions T184M, Q200H, K207N, and K214R) within this group that were distinct from all other DHAV-3 strains. Conclusions: This is the first report of molecular characterization of DHAVs in Vietnam. At least two genotypes were identified, DHAV-1 and DHAV-3, with diversified clades within and between genotypes. DHAV-3 seemed to be dominant in Vietnam.

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Section: Introductionmentioning

confidence: 89%

Molecular genotyping of duck hepatitis A viruses (DHAV) in Vietnam

Doan

Thi

et al. 2016

J Infect Dev Ctries

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“…Discussion DVH, especially the new type of DVH caused by DHAV-C and reported in recent years in mainland China and Korea (Kim et al, 2007;Wang et al, 2008), is a severe disease resulting in huge economic losses. This disease has brought great difficulties in the prevention and control of the disease in duck-rearing regions.…”

Section: Methodsmentioning

confidence: 99%

“…They are widely epidemic in duckrearing areas worldwide. The pathogen of a new-type of DVH prevalent in Asia in recent years was proved to be a picornavirus (Kim et al, 2007;Tseng et al, 2007;Wang et al, 2008). The serotype of this new type of DHV was not related to conventional DHV-1, although they both belong to the Picornaviridae family (Kim et al, 2007;Tseng et al, 2007).…”

Section: Introductionmentioning

confidence: 96%

“…The pathogen of a new-type of DVH prevalent in Asia in recent years was proved to be a picornavirus (Kim et al, 2007;Tseng et al, 2007;Wang et al, 2008). The serotype of this new type of DHV was not related to conventional DHV-1, although they both belong to the Picornaviridae family (Kim et al, 2007;Tseng et al, 2007). Hence, the DHV in the Picornaviridae family was renamed duck hepatitis A virus (DHAV) (Wang et al, 2008) in order to better distinguish the different serotypes or genotypes of DHV in the Picornaviridae family.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, the DHV in the Picornaviridae family was renamed duck hepatitis A virus (DHAV) (Wang et al, 2008) in order to better distinguish the different serotypes or genotypes of DHV in the Picornaviridae family. DHAV was divided into three genotypes*genotype A (DHAV-A), genotype B (DHAV-B) and genotype C (DHAV-C)*according to the genetic structure of the viruses (Wang et al, 2008), which relate to the original type of DHV-1 (Kim et al, 2006), the new serotype isolated in Taiwan (Tseng et al, 2007) and the new-type DHV isolated in Korea and mainland China (Kim et al, 2007;Wang et al, 2008) respectively. DVH is characterized clinically as an acute infection causing high mortality and later neurological signs.…”

Section: Introductionmentioning

confidence: 99%

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An experimental study of the pathogenicity of a duck hepatitis A virus genotype C isolate in specific pathogen free ducklings

Zhang

Tang

et al. 2012

Avian Pathology

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Duck hepatitis A virus genotype C (DHAV-C), recognized recently, is one of the pathogens causing fatal duck viral hepatitis in ducklings, especially in Asia. To demonstrate the pathogenesis of the DHAV-C isolate, 3-day-old specific pathogen free ducklings were inoculated subcutaneously with a DHAV-C isolate and the clinical signs were observed. Virus distribution, histological and apoptotic morphological changes of various tissues were examined at different times post inoculation. The serial, characteristic changes included haemorrhage and swelling of the liver. Apoptotic cells and virus antigen staining were found in all of the tissues examined. Where more virus antigen staining was detected, there were more severe histopathological and apoptotic changes. The amount of virus antigen and the histological and apoptotic morphological changes agreed with each other and became increasingly severe with length of time after infection. Apoptotic cells were ubiquitously distributed, especially among lymphocytes, macrophages and monocytes in immune organs such as the bursa of Fabricius, thymus and spleen, and in liver, kidney and cerebral cells. Necrosis was also observed within 72 h post inoculation in all organs examined, except the cerebrum, and was characterized by cell swelling and collapsed plasma membrane. These results suggest that the recent outbreak of disease caused by DHAV-C virus is pantropic, causing apoptosis and necrosis of different organs. The apoptosis and necrosis caused by the DHAV-C field strain in this study is associated with pathogenesis and DHAV-C-induced lesions.

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Characterization of monoclonal antibodies against duck hepatitis type 1 virus VP1 protein

Zhang

et al. 2014

Journal of Virological Methods

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Recent Korean isolates of duck hepatitis virus reveal the presence of a new geno- and serotype when compared to duck hepatitis virus type 1 type strains

Cited by 9 publications

References 0 publications

Molecular genotyping of duck hepatitis A viruses (DHAV) in Vietnam

Molecular genotyping of duck hepatitis A viruses (DHAV) in Vietnam

An experimental study of the pathogenicity of a duck hepatitis A virus genotype C isolate in specific pathogen free ducklings

Characterization of monoclonal antibodies against duck hepatitis type 1 virus VP1 protein

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