Recent investigation on heterocycles with one nitrogen [piperidine, pyridine and quinoline], two nitrogen [1,3,4-thiadiazole and pyrazole] and three nitrogen [1,2,4-triazole]: a review

Zabiulla,; S, Asha M.; Al‐Ghorbani, Mohammed; Al-Ostoot, Fares Hezam

doi:10.1007/s13738-021-02293-x

Cited by 12 publications

(2 citation statements)

References 148 publications

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“…While there have been significant advancements in cancer treatment, many current drugs can cause serious side effects and may not be effective enough in certain cases [ 1 ]. The development of new, safer, and more effective drugs for cancer is crucial [ [2] , [3] , [4] ]. This requires a greater comprehension of the underlying mechanisms of cancer and the identification of new targets for therapy [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, DFT, Hirshfeld surface analysis, energy frameworks and in-Silico drug-targeting PFKFB3 kinase of novel triazolequinoxalin derivative (TZQ) as a therapeutic Strategy against cancer

Abad,

Al-Ostoot,

Ashraf

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, DFT, Hirshfeld surface analysis, energy frameworks and in-Silico drug-targeting PFKFB3 kinase of novel triazolequinoxalin derivative (TZQ) as a therapeutic Strategy against cancer

Abad,

Al-Ostoot,

Ashraf

et al. 2023

Heliyon

Self Cite

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“…Synthesis of highly functionalized organic molecules is done using multicomponent reactions. Researchers have thoroughly exploited these structural features of heterocycles over the last three decades (2).…”

Section: Introductionmentioning

confidence: 99%

Spectral Investigations, DFT Studies, ADME Analysis, Molecular Docking of New Piperidine Derivatives with Potential Antimicrobial Activity

Agrawal,

Patel,

Thakur

et al. 2023

IJST

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Objective: To explore the possibility of obtaining effective and harmless antibacterial drugs by conventional synthesis of new piperidine analogs. Methods: The target compound was carried out by cyclization reaction involving aromatic aldehydes and amine and further evaluated for their antimicrobiological assay using agar disc diffusion method. Computational investigation such as density functional theory (DFT) was carried out by B3LYP/6-31G (d,p) method to evaluate their electronic characteristics. Absorption, Distribution, Metabolism, and Excretion (ADME) properties were evaluated using the Swiss ADME server. The Antimicrobial activity was investigated using molecular docking and that molecule was prepared using MGL Tools 1.5.7. Auto Dock Vina 1.2.0. Findings: Among all the synthesized compounds 5a to 5h, compounds 5b and 5e showed good anti-bacterial properties against three pathogenic bacterial strains. B. subtilis is inhibited by compound 5b at a concentration of 26 mm. B. subtilis is inhibited by compound 5e at a concentration of 25 mm. Molecular Docking revealed that molecules 5b and 5e consistently showed a large binding affinity for all six target proteins, which was similar to that of the reference molecule, streptomycin. Drug-likeness predictions and the ADME analysis showed that most of the molecules do not violate any of the five Lipinski rule while some have only one or two violations, primarily because of high molecular weight. Novelty: In order to investigate the anti-bacterial impact of piperidine derivatives, a lot of work has been put into their synthesis and evaluation. These results might influence the creation and advancement of anti-microbial medication candidates that are more potent.

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Synthetic and Medicinal Perspective of 1,2,4‐Triazole as Anticancer Agents

Rathod

Kumar

2022

Chemistry & Biodiversity

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Cancer is still one of the leading causes of death worldwide. Many researchers are working to design and develop heterocyclic-based drugs with the potential to treat cancer at various stages. There is always an unmet need to discover new anticancer drugs to treat different types of cancer. Based on literature reports, it was evident that hybrid 1,2,4-triazoles exhibit a wide spectrum of biological potential (particularly potent anticancer activity), as compared to the corresponding monocyclic compounds. In this review, we summarized fused/hybrid 1,2,4-triazole and poly-functionalized 1,2,4-triazoles as anticancer agents. Triazole may be fused with other heterocyclic scaffolds like pyrimidine, pyridine, piperidine, quinoxaline, quinazoline, thiadiazine, indole, phthalazine etc. A clear explanation of the method of synthesis, structure-activity relationship, and in vitro results plus the inhibitory concentration of new molecules are focused on in this review article.

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Recent investigation on heterocycles with one nitrogen [piperidine, pyridine and quinoline], two nitrogen [1,3,4-thiadiazole and pyrazole] and three nitrogen [1,2,4-triazole]: a review

Cited by 12 publications

References 148 publications

Synthesis, crystal structure, DFT, Hirshfeld surface analysis, energy frameworks and in-Silico drug-targeting PFKFB3 kinase of novel triazolequinoxalin derivative (TZQ) as a therapeutic Strategy against cancer

Synthesis, crystal structure, DFT, Hirshfeld surface analysis, energy frameworks and in-Silico drug-targeting PFKFB3 kinase of novel triazolequinoxalin derivative (TZQ) as a therapeutic Strategy against cancer

Spectral Investigations, DFT Studies, ADME Analysis, Molecular Docking of New Piperidine Derivatives with Potential Antimicrobial Activity

Synthetic and Medicinal Perspective of 1,2,4‐Triazole as Anticancer Agents

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