Recent insights into the biological functions of apigenin

Kim, Jae Kwang; Park, Sang Un

doi:10.17179/excli2020-2579

Cited by 6 publications

(5 citation statements)

References 66 publications

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“…Studies have suggested that apigenin has a strong background in the prevention of numerous infections by using different experimental analyses [5]. The anti-inflammatory and antioxidant potential of apigenin [9,10] induces apoptosis and proliferation at a cellular level in host organisms and halts the overexpression of cancer-causing genes [11,12]. Apigenin regulates cell death by activating various intrinsic apoptotic pathways and caspase-3 activity, resulting in forming apoptotic protease activating factor 1(APAF) by liberating one of the components of the electron transport chain named cytochrome C [13].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways

Abid¹,

Ghazanfar²,

Farid

et al. 2022

Molecules

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Plant bioactive compounds, particularly apigenin, have therapeutic potential and functional activities that aid in the prevention of infectious diseases in many mammalian bodies and promote tumor growth inhibition. Apigenin is a flavonoid with low toxicities and numerous bioactive properties due to which it has been considered as a traditional medicine for decades. Apigenin shows synergistic effects in combined treatment with sorafenib in the HepG2 human cell line (HCC) in less time and statistically reduces the viability of tumor cells, migration, gene expression and apoptosis. The combination of anti-cancerous drugs with apigenin has shown health promoting potential against various cancers. It can prevent cell mobility, maintain the cell cycle and stimulate the immune system. Apigenin also suppresses mTOR activity and raises the UVB-induced phagocytosis and reduces the cancerous cell proliferation and growth. It also has a high safety threshold, and active (anti-cancer) doses can be gained by consuming a vegetable and apigenin rich diet. Apigenin also boosted autophagosome formation, decreased cell proliferation and activated autophagy by preventing the activity of the PI3K pathway, specifically in HepG2 cells. This paper provides an updated overview of apigenin’s beneficial anti-inflammatory, antibacterial, antiviral, and anticancer effects, making it a step in the right direction for therapeutics. This study also critically analyzed the effect of apigenin on cancer cell signaling pathways including the PI3K/AKT/MTOR, JAK/STAT, NF-κB and ERK/MAPK pathways.

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Section: Introductionmentioning

confidence: 99%

Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways

Abid¹,

Ghazanfar²,

Farid

et al. 2022

Molecules

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“…This is in line with a study that demonstrated the antioxidant properties of apigenin on sperm and testis 34 . Apigenin may reduce oxidative stress and lipid peroxidation in sperm, by scavenging ROS and enhancing the activity of antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GPX), and total antioxidant capacity (TAC) 34 – 36 . Kopalli, et al 37 investigated the protective effects of apigenin against oxidative damage in testicular sperm cells.…”

Section: Discussionmentioning

confidence: 99%

Apigenin supplementation substantially improves rooster sperm freezability and post-thaw function

Najafi,

Mohammadi,

Sharifi

et al. 2024

Sci Rep

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This pioneering research investigated apigenin potential to augment rooster sperm cryosurvival in an extender model. Apigenin is a natural antioxidant flavonoid showing promise for improved post-thaw sperm function. However, its effects on avian semen cryopreservation remain unexplored. This first study supplemented rooster sperm Lake extender with 0, 50, 100, 200, 400 μmol/L apigenin to determine the optimal concentrations for post-thaw quality. Supplementation with 100 μmol/L apigenin resulted in significant enhancements in total motility (from 41.5% up to 71.5%), progressive motility (18.1% to 29.1%) (p < 0.05), membrane integrity (40% to 68%), mitochondrial function (p < 0.001), viability (37% to 62%) and total antioxidant capacity (p < 0.001) compared to the control. It also substantially reduced percentages of abnormal morphology, reactive oxygen species and apoptosis (p < 0.001). Although 200 μmol/L apigenin significantly enhanced some attributes, effects were markedly lower than 100 μmol/L. Higher doses did not improve cryoprotective parameters. This indicates 100 μmol/L as the optimal apigenin concentration. This represents the first report of apigenin protecting rooster sperm from cryodamage. The natural antioxidant improved post-thaw sperm quality, likely by suppressing oxidative stress and apoptosis. Apigenin shows promise for enhancing rooster sperm cryosurvival.

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“…All vinegars tested contained dihydroxybenzoic acid, 4-hydroxybenzoic acid, caffeic acid, 2-hydroxycinnamic acid, and myricetin. Apigenin, which exhibits a range of health-promoting properties including antibacterial, antiviral, antiproliferative, antiinflammatory, antioxidant, anti-angiogenic, and anticancer activities, was only contained in apple vinegar [68]. Sinapic acid, which is a compound with multiple health benefits, i.e., antioxidant, anti-inflammatory, anticancer, antimutagenic, antiglycaemic, neuroprotective, and antimicrobial effects, was only found in two of the vinegars: the lemon vinegar and the pear vinegar [69].…”

Section: Discussionmentioning

confidence: 99%

The Chemical Profiles and Antioxidant Properties of Live Fruit or Vegetable Vinegars Available on the Polish Food Market

Melkis,

Jakubczyk

2024

Foods

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Live vinegar is a product formed through a two-step fermentation process of a sugar substrate that has not been subjected to filtration or pasteurization. This is considered to preserve all nutrients and biologically active microorganisms, making it a product with a valuable composition and beneficial properties. Therefore, the purpose of this study was to analyze the chemical composition and antioxidant properties of the selected vinegars available on the Polish food market. The material in the study consisted of four live (naturally turbid, unfiltered, unpasteurized) fruit or vegetable vinegars: apple, pear, rhubarb, and lemon. Spectrophotometric, HPLC, and GC methods were used. Among the vinegars tested, lemon vinegar had the highest vitamin C content—15.95 mg/100 mL. Apple vinegar proved to be the best source of polyphenols and flavonoids (TPC—191.97 mg GAE/L, TFC—70.22 mg RE/L). All of the vinegars contained dihydroxybenzoic acid, 4-hydroxybenzoic acid, caffeic acid, 2-hydroxycinnamic acid, and myricetin. The acetic acid content of the tested vinegars ranged from 29.180 to 38.125 mM/L. The pH values ranged from 3.14 to 3.41. In conclusion, the most promising nutraceutical with potentially beneficial health-promoting properties seems to be apple vinegar.

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Recent insights into the biological functions of apigenin

Cited by 6 publications

References 66 publications

Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways

Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways

Apigenin supplementation substantially improves rooster sperm freezability and post-thaw function

The Chemical Profiles and Antioxidant Properties of Live Fruit or Vegetable Vinegars Available on the Polish Food Market

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