Recent insights into respiratory modulation of brain activity offer new perspectives on cognition and emotion

Heck, Detlef H.; Correia, Brittany; Fox, Mia B.; Liu, Yu; Allen, Micah; Varga, Somogy

doi:10.1016/j.biopsycho.2022.108316

Cited by 25 publications

(16 citation statements)

References 139 publications

(161 reference statements)

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“…A second line of research should focus on potential translational applications of respiration- brain coupling. While others have made a convincing case for studying respiratory involvement in clinical contexts before (for an excellent review, see 48 ), the results presented here demonstrate a novel link between bodily signals and aperiodic neural activity. Importantly, changes in 1/f slope itself - an indicator of E:I imbalance - have been implicated in neurological and psychiatric disorders like Alzheimer’s disease 49 , schizophrenia 50 , autism spectrum disorder 51 , and epilepsy 52 .…”

Section: Discussionmentioning

confidence: 64%

Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling

Kluger

Forster

Abbasi

et al. 2022

Preprint

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Bodily rhythms such as respiration are increasingly acknowledged to modulate neural oscillations underlying human action, perception, and cognition. Conversely, the link between respiration and aperiodic brain activity - a non-oscillatory reflection of excitation-inhibition (E:I) balance - has remained unstudied. Aiming to disentangle potential respiration-related dynamics of periodic and aperiodic activity, we applied novel algorithms of time-resolved parameter estimation to resting-state M/EEG data from two recording sites (N = 78). Our findings highlight the role of respiration as a physiological influence on brain signalling. We provide first evidence that fluctuations of aperiodic brain activity (1/f slope) are phase-locked to the respiratory cycle which strongly suggests that spontaneous state shifts of excitation-inhibition balance are at least partly influenced by peripheral bodily signals. Moreover, differential temporal dynamics in their coupling to non-oscillatory and oscillatory activity point towards a functional distinction in the way each component is related to respiration.

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Section: Discussionmentioning

confidence: 64%

Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling

Kluger

Forster

Abbasi

et al. 2022

Preprint

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“…Evidence has demonstrated that neural responses to heartbeats contribute to visual 14 , somatosensory 15 , auditory 16,17 , and self-perception [18][19][20] . Further, recent evidence has suggested that breathing is aligned with the perception of sensory inputs 21,22 , suggesting that it is involved in perceptual sensitivity modulation and, possibly, shaping neural dynamics 23,24 .…”

Section: Confounding Effects Of Heart Rate Breathing Rate and Frontal...mentioning

confidence: 99%

Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception

Candia-Rivera

Sappia

Horschig³

et al. 2022

Sci Rep

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Recent studies have established that cardiac and respiratory phases can modulate perception and related neural dynamics. While heart rate and respiratory sinus arrhythmia possibly affect interoception biomarkers, such as heartbeat-evoked potentials, the relative changes in heart rate and cardiorespiratory dynamics in interoceptive processes have not yet been investigated. In this study, we investigated the variation in heart and breathing rates, as well as higher functional dynamics including cardiorespiratory correlation and frontal hemodynamics measured with fNIRS, during a heartbeat counting task. To further investigate the functional physiology linked to changes in vagal activity caused by specific breathing rates, we performed the heartbeat counting task together with a controlled breathing rate task. The results demonstrate that focusing on heartbeats decreases breathing and heart rates in comparison, which may be part of the physiological mechanisms related to “listening” to the heart, the focus of attention, and self-awareness. Focusing on heartbeats was also observed to increase frontal connectivity, supporting the role of frontal structures in the neural monitoring of visceral inputs. However, cardiorespiratory correlation is affected by both heartbeats counting and controlled breathing tasks. Based on these results, we concluded that variations in heart and breathing rates are confounding factors in the assessment of interoceptive abilities and relative fluctuations in breathing and heart rates should be considered to be a mode of covariate measurement of interoceptive processes.

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“…Evidence has demonstrated that neural responses to heartbeat contribute to visual 9 , somatosensory 10 , auditory 11,12 , and self-perception [13][14][15] . Further, recent evidence has suggested that respiration is aligned with the perception of sensory inputs 16,17 , suggesting that it is involved in perceptual sensitivity modulation and, possibly, shaping neural dynamics 18 .…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20] Further, recent evidence has suggested that breathing is aligned with the perception of sensory inputs, 21,22 suggesting that it is involved in perceptual sensitivity modulation and, possibly, shaping neural dynamics. 23,24 Heartbeat-evoked potential has been repeatedly reported as a metric for interoceptive awareness, for both comparing good heartbeat-sensing performances with bad ones and correlating it with the estimated interoceptive accuracy (early evidence provided by Pollatos and Schandry, 2004, 25 a recent validation in heart-transplanted patients reported by Salamone et al, 2020, 26 and a review by Coll et al, 2021 andPark andBlanke, 2019). 27,28 Recent evidence has demonstrated that fluctuations in heart rate induce changes in stroke volume, which affects the estimation of heartbeat-evoked responses.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception

Candia-Rivera

Sappia

Horschig³

et al. 2022

Preprint

View full text Add to dashboard Cite

Recent studies have established that cardiac and respiratory phases can modulate perception and related neural dynamics. While heart rate and respiratory sinus arrhythmia are possibly affecting interoception biomarkers, such as heartbeat-evoked potentials, the relative changes in heart rate and cardiorespiratory dynamics in interoceptive processes have not yet been investigated. In this study, we investigated the variation in heart and respiration rates, as well as higher functional dynamics including cardiorespiratory correlation and frontal hemodynamics, during cardiac awareness tasks. To further investigate the functional physiology linked to changes in vagal activity caused by specific respiratory rates, we studied cardiac awareness and controlled respiration rate. The results demonstrate that focusing on heartbeats decreases respiration and heart rates in comparison, which may be part of the physiological mechanisms related to 'listening' to the heart, the focus of attention, and self-awareness. Focusing on heartbeats was also observed to increase frontal connectivity, supporting the role of frontal structures in the neural monitoring of visceral inputs. However, cardiorespiratory correlation is affected by both interoceptive and controlled respiration. Based on these results, we concluded that variations in heart and respiratory rates are confounding factors in the assessment of interoceptive abilities and relative fluctuations in respiration and heart rates should be considered to be a mode of covariate measurement of interoceptive processes.

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Recent insights into respiratory modulation of brain activity offer new perspectives on cognition and emotion

Cited by 25 publications

References 139 publications

Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling

Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling

Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception

Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception

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