Recent insights into near-infrared light-responsive carbon dots for bioimaging and cancer phototherapy

Zhou, Bo; Guo, Zhengxi; Lin, Zhaoxing; Zhang, Lizheng; Jiang, Bang‐Ping; Shen, Xing‐Can

doi:10.1039/c9qi00201d

Cited by 79 publications

(32 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Owing to the diverse structures of CDs synthesized from various precursors under different conditions, CDs usually exhibit specific properties, including high hydrophilicity, low toxicity, long‐wavelength emission and two‐photon (TP) fluorescence. [ 68–71 ]…”

Section: Characteristics Of Cdsmentioning

confidence: 99%

Applications of carbon dots on tumour theranostics

et al. 2021

VIEW

View full text Add to dashboard Cite

Carbon dots (CDs) have been extensively investigated as prime candidates for developing tumour theranostic platform due to their tunable fluorescence emission and excitation, good photostability, high water solubility and biocompatibility. Herein, we will update the recent research and latest development on the preparation, hydrophilicity, biotoxicity and optical property of CDs, as well as their applications in multimodal bioimaging and anticancer drug delivery. We will mainly highlight their applications in in vivo imaging and tumour‐targeted theranostics with a special emphasis on large amino acid‐mimicking carbon quantum dots‐based tumour theranostics through a large neutral amino acid transporter 1 (LAT1)‐mediated targeted strategy. Finally, we will also discuss the current status, key challenges and future directions of CDs in tumour theranostics. We expect that this review will summarize recent advances to inspire more researches on CDs for biomedical and clinical applications in the near future.

show abstract

Section: Characteristics Of Cdsmentioning

confidence: 99%

Applications of carbon dots on tumour theranostics

et al. 2021

VIEW

View full text Add to dashboard Cite

show abstract

“…Because of these excellent properties, carbon-based nanomaterials have become promising alternatives to other nanomaterials in a variety of biological applications, such as imaging, sensing and drug delivery (Xu Q. et al, 2019). Among all these carbon-based nanomaterials, 0D carbon-based nanomaterials have inimitable electrical, optical properties, low toxicity and high quantum yield; therefore can be used to produce micro-sensors with superior performance and low power consumption (Shi et al, 2019;Zhou et al, 2019). In this section, we will give a detailed introduction to the latest progress in the application of 0D carbon-based nanomaterials in the field of biosensing.…”

Section: D Carbon-based Nanomaterialsmentioning

confidence: 99%

Application of Zero-Dimensional Nanomaterials in Biosensing

et al. 2020

View full text Add to dashboard Cite

Zero-dimensional (0D) nanomaterials, including graphene quantum dots (GQDs), carbon quantum dots (CQDs), fullerenes, inorganic quantum dots (QDs), magnetic nanoparticles (MNPs), noble metal nanoparticles, upconversion nanoparticles (UCNPs) and polymer dots (Pdots), have attracted extensive research interest in the field of biosensing in recent years. Benefiting from the ultra-small size, quantum confinement effect, excellent physical and chemical properties and good biocompatibility, 0D nanomaterials have shown great potential in ion detection, biomolecular recognition, disease diagnosis and pathogen detection. Here we first introduce the structures and properties of different 0D nanomaterials. On this basis, recent progress and application examples of 0D nanomaterials in the field of biosensing are discussed. In the last part, we summarize the research status of 0D nanomaterials in the field of biosensing and anticipate the development prospects and future challenges in this field.

show abstract

“…The change in band gap and size permits them to emit photons from the visible to the near infra-red region. The emission of photons as a result of variance in atomic composition enables the tuning of the absorption spectra [21,22]. Their usefulness in bio imaging, phototherapy, drug delivery and biosensing can be attributed to their size dependent optical properties and tunable emissions to the near infrared region [23,24].…”

Section: Key Concept Of Ternary Qdsmentioning

confidence: 99%

Synthesis strategies and application of ternary quantum dots — in cancer therapy

Aladesuyi

Oluwafemi

2020

Nano-Structures & Nano-Objects

View full text Add to dashboard Cite

Semiconductor nanoparticles also known as quantum dots (QDs) have continued to receive more attention from researchers due to their unique optical, magnetic and photo physical properties which made them useful as biomedical materials, solar cells, catalyst etc. However, ternary I-III-VI QDs have shown to be a safer alternative to the binary II-VI or IV-VI QDs due to the absent of heavy toxic elements such as Cd and Pb. Cancer management and therapy in Africa has been bedevilled by a lot of challenges such as inaccurate diagnosis and ineffective therapeutic methods. Therefore, the need to develop an appropriate approach for cancer detection and treatment is of paramount importance. Tunable optical properties and absorption in the near infra-red region of the ternary QDs makes them useful as fluorescent probes in cancer detection and treatment. They have the ability to detect specific cancer cells including those that are not easily detected by modern imaging technique. Also, properties such as non-bleaching, stability, water solubility etc. made them a desirable fluorophore when compared to conventional dyes. Most cancer drugs suffer from inherent shortcomings such as limited absorption, insolubility and aggregation. However, these shortcomings can be overcome when these drugs are applied in form of conjugated systems. The use of QDs as conjugates has revolutionise the treatment of cancer in the 21st century. This review provides information about the synthesis strategies, optical properties, hydrophilization and bioconjugation of ternary I-III-VI QDs. Furthermore, we described the various biomedical applications in biosensors, bioimaging, drug delivery and phototherapeutic techniques. Finally, we looked at the challenges and future perspective of these QDs in cancer management.

show abstract

Recent insights into near-infrared light-responsive carbon dots for bioimaging and cancer phototherapy

Abstract: The current developments of NIR-responsive CDs and their applications in bioimaging and phototherapy are highlighted in this review.

Cited by 79 publications

References 108 publications

Applications of carbon dots on tumour theranostics

Applications of carbon dots on tumour theranostics

Application of Zero-Dimensional Nanomaterials in Biosensing

Synthesis strategies and application of ternary quantum dots — in cancer therapy

Contact Info

Product

Resources

About