Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease

Wu, Gao-Qi; Xu, Yan‐Ming; Lau, Andy T. Y.

doi:10.1186/s12935-020-01226-7

Cited by 31 publications

(25 citation statements)

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“…eIF5A1 is abundantly expressed in most cells and functions as a translation elongation factor. It was also shown that eIF5A1 is implicated in certain human diseases, including diabetes, several human cancer types, viral infections and diseases of the nervous system ( 12 ). Meanwhile, eIF5A2 is overexpressed in numerous cancers, expressed few normal tissues, is a candidate oncogene and plays an important role in the development and progression of cancers ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)

et al. 2020

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Cancer is the leading cause of death worldwide. The absence of obvious symptoms and insufficiently sensitive biomarkers in early stages of carcinoma limits early diagnosis. Cancer therapy agents and targeted therapy have been used extensively against tissues or organs of specific cancers. However, the intrinsic and/or acquired resistance to the agents or targeted drugs as well as the serious toxic side effects of the drugs would limit their use. Therefore, identifying biomarkers involved in tumorigenesis and progression represents a challenge for cancer diagnosis and therapeutic strategy development. The eukaryotic translation factor 5A (eIF5A), originally identified as an initiation factor, was later shown to promote translation elongation of iterated proline sequences. There are two eIF5A isoforms (eIF5A1 and eIF5A2). eIF5A2 protein consists of 153 residues, and shares 84% amino acid identity with eIF5A1. However, the biological functions of these two isoforms may be significantly different. Recently, it was demonstrated that eIF5Ais widely involved in the pathogenesis of a number of diseases, including cancers. In particular, eIF5A plays an important role in regulating tumor growth, invasion, metastasis and tumor microenvironment. It was also shown to serve as a potential biomarker and target for the diagnosis and treatment of cancers. The present review briefly discusses the latest findings of eIF5A in the pathogenesis of certain malignant cancers and evolving clinical applications.

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Section: Introductionmentioning

confidence: 99%

Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)

et al. 2020

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“…EIF5A is important both for translational elongation, particularly at ribosome stalling sites, and for termination 38 . EIF5A2 may also function in mRNA decay in response to stress 39 , and both factors have been implicated in human diseases such as cancer 40 .…”

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confidence: 99%

Neuronal control of maternal provisioning in response to social cues

Wasson

Harris

Keppler-Ross

et al. 2021

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Mothers contribute cytoplasmic components to their progeny in a process called maternal provisioning. Provisioning is influenced by the parental environment, but the molecular pathways that transmit environmental cues from mother to progeny are not well understood. Here we show that in C. elegans, social cues modulate maternal provisioning to regulate gene silencing in offspring. Intergenerational signal transmission depends on a pheromone-sensing neuron and neuronal FMRF (Phe-Met-Arg-Phe)-like peptides. Parental FMRF signaling promotes the deposition of mRNAs for translational components in progeny, which in turn reduces gene silencing. Previous studies had implicated FMRF signaling in short-term responses such as modulated feeding behavior in response to the metabolic state1,2, but our data reveal a broader role, to coordinate energetically expensive processes such as translation and maternal provisioning. This study identifies a new pathway for intergenerational communication, distinct from previously discovered pathways involving small RNAs and chromatin, that links sensory perception to maternal provisioning.

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“…EIF5A is important both for translational elongation, particularly at ribosome stalling sites, and for termination ( 43 ). EIF5A2 may also function in mRNA decay in response to stress ( 44 ), and both factors have been implicated in human diseases such as cancer ( 45 ).…”

Section: Resultsmentioning

confidence: 99%

Neuronal control of maternal provisioning in response to social cues

et al. 2021

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Mothers contribute cytoplasmic components to their progeny in a process called maternal provisioning. Provisioning is influenced by the parental environment, but the molecular pathways that transmit environmental cues between generations are not well understood. Here, we show that, in Caenorhabditis elegans, social cues modulate maternal provisioning to regulate gene silencing in offspring. Intergenerational signal transmission depends on a pheromone-sensing neuron and neuronal FMRFamide (Phe-Met-Arg-Phe)-like peptides. Parental FMRFamidelike peptide signaling dampens oxidative stress resistance and promotes the deposition of mRNAs for translational components in progeny, which, in turn, reduces gene silencing. This study identifies a previously unknown pathway for intergenerational communication that links neuronal responses to maternal provisioning. We suggest that loss of social cues in the parental environment represents an adverse environment that stimulates stress responses across generations.

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Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease

Cited by 31 publications

References 123 publications

Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)

Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)

Neuronal control of maternal provisioning in response to social cues

Neuronal control of maternal provisioning in response to social cues

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Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease

Cited by 31 publications

References 123 publications

Eukaryotic translation initiation factor&nbsp;5A in the pathogenesis of cancers (Review)

Eukaryotic translation initiation factor&nbsp;5A in the pathogenesis of cancers (Review)

Neuronal control of maternal provisioning in response to social cues

Neuronal control of maternal provisioning in response to social cues

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Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)

Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)