Recent insights in nanotechnology-based drugs and formulations designed for effective anti-cancer therapy

Abstract

The rapid development of nanotechnology provides alternative approaches to overcome several limitations of conventional anti-cancer therapy. Drug targeting using functionalized nanoparticles to advance their transport to the dedicated site, became a new standard in novel anti-cancer methods. In effect, the employment of nanoparticles during design of antineoplastic drugs helps to improve pharmacokinetic properties, with subsequent development of high specific, non-toxic and biocompatible anti-cancer agents. However, the physicochemical and biological diversity of nanomaterials and a broad spectrum of unique features influencing their biological action requires continuous research to assess their activity. Among numerous nanosystems designed to eradicate cancer cells, only a limited number of them entered the clinical trials. It is anticipated that progress in development of nanotechnology-based anti-cancer materials will provide modern, individualized anti-cancer therapies assuring decrease in morbidity and mortality from cancer diseases. In this review we discussed the implication of nanomaterials in design of new drugs for effective antineoplastic therapy and describe a variety of mechanisms and challenges for selective tumor targeting. We emphasized the recent advantages in the field of nanotechnology-based strategies to fight cancer and discussed their part in effective anti-cancer therapy and successful drug delivery.

Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

“…An emerging therapeutic strategy is the use of nanoparticles as drug carriers. 19,20 Studies show that the immobilization/encapsulation process improves the overall biological effectiveness of active agents including pharmacokinetic parameters (bioavailability, clearance) and reduces the side effects. [21][22][23] In addition, it has been noted that the antibiotic resistance of drug-resistant pathogens may be overcome by using nanoparticles as antibiotic carriers.…”

“…24 Among the many types of nanostructures, core-shell magnetic iron oxide nanoparticles are the most commonly used drug carriers in biomedical studies. 20,25 Due to their unique properties (size, magnetic moment, surface properties), the use of magnetic nanomaterials (MNPs) may represent a new approach for the treatment of infections caused by drugresistant pathogens. These nanoparticles are able to interact with planktonic bacteria as well as those embedded in a biofilm matrix.…”

CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells

“…[8][9][10][11][12] The enhanced permeability and retention effect is the theoretical foundation of tissue targeting of nanoparticle delivery systems. Nanoscale drug delivery systems (NDDS) have shown physical, chemical, pharmacokinetic, and pharmacodynamics properties, which give them advantages when compared with conventional pharmaceutical preparations in the treatment of malignant tumors.…”

Enzymosomes: A Rising Effectual Tool for Targeted Drug Delivery System

“…In the research work done in the reference article, the maleimide derivatives of lipids were cross-connected better due to the presence of long spacing reactive arms [93]. The enzyme is then coupled with these liposomes and is designed in such a manner to use its ability to conjugate in a specific manner with membrane-linked antigens, producing different nanocarriers with physicochemical features efficient as a drug delivery system [94].…”