Recent insight into potential acute respiratory distress syndrome

Amin, Zulkifli; Rahmawati, Fitriana Nur

doi:10.15537/smj.2017.4.15843

Cited by 8 publications

(7 citation statements)

References 54 publications

(98 reference statements)

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“…Increased IL-6 plasma levels correlated with morbidity and mortality in COVID-19 patients [32,33]. Furthermore, this cytokine might be directly involved in the pathogenesis of acute lung injury, presumably via recruitment of inflammatory cells in the lung [34][35][36]. It is a hallmark cytokine released during macrophage activation syndrome and cytokine storm, which are both potential key processes in COVID-19 disease exacerbation [37].…”

Section: Discussionmentioning

confidence: 99%

Lung Ultrasound and Respiratory Pathophysiology in Mechanically Ventilated COVID-19 Patients—an Observational Trial

Rojatti

Regli

Zanforlin

et al. 2020

SN Compr. Clin. Med.

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The relationship between respiratory system mechanics, lung ultrasound (LUS) abnormalities, and mortality in mechanically ventilated patients with COVID-19-associated respiratory failure is unknown. We assessed the pattern of respiratory mechanics and LUS, their changes over time, and the differences between survivors and non-survivors. We additionally analyzed the relationship between LUS findings and the severity of gas exchange impairment and interleukin 6 (IL-6). This was a twocenter retrospective, observational trial carried out in the intensive care units of the hospitals of Bolzano and Merano, Italy, from March 15 to April 20, 2020. We enrolled 41 consecutive patients. Seven patients (17%, 95% CI 8.5-31.3%) died. Mean compliance of the respiratory system on ICU admission was 41.6 (± 18.8) ml/mbar (42.5 (± 19.6) for survivors, 38.0 (± 16.3) for deceased, p = 0.605). Non-survivors had a significantly lower compliance over time, decreasing from day 14 after symptom onset, compared with survivors (p = 0.008). Mean LUS score on admission was 11.2 (± 3.7) and survivors had lower LUS scores on admission than non-survivors (10.5 (± 3.6), 13.9 (2.8), respectively, t test, p = 0.029). LUS score correlated with IL-6 concentrations (r = 0.52, p = 0.001) and arterial pCO 2 (r = 0.30, p = 0.033) and was inversely correlated with oxygenation (r = − 0.34, p = 0.001). No correlation was found between LUS and respiratory system compliance (r = − 0.02, p = 0.299). Nonsurvivors from COVID-19-associated respiratory failure had a significant decrease in compliance after day 14 of symptom onset. Compliance did not correlate with the degree of abnormalities found in LUS, but LUS score correlated with oxygenation, pCO 2 , and IL-6. Keywords COVID-19. ARDS. Mechanical ventilation. Lung ultrasound. Respiratory mechanics Background A new form of viral pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China, in December 2019 [1-3]. Due to its transmission dynamics, the virus spread quickly across the globe within a very short time and on March 11, 2020, the WHO declared the outbreak a pandemic [4]. Studies from Marco Rojatti and Ivo B. Regli contributed equally to this work. This article is part of the Topical Collection on COVID-19

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Section: Discussionmentioning

confidence: 99%

Lung Ultrasound and Respiratory Pathophysiology in Mechanically Ventilated COVID-19 Patients—an Observational Trial

Rojatti

Regli

Zanforlin

et al. 2020

SN Compr. Clin. Med.

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“…The immune system is a key player in the etiology of ARDS, according to current knowledge [4]. The severity of lung injury in ARDS patients was linked to serum cytokine and chemokine levels [5]. Infected epithelial cells release cytokines, which attract leukocytes, macrophages, and nearby endothelial cells, causing an increase in cytokine and chemokine production and the symptom known as cytokine storm [6].…”

Section: Introductionmentioning

confidence: 99%

Bio Actives from Albizia Lebbeck on Acute Lung Injury/ Acute Respiratory Distress Syndrome Molecular Targets: In-Silico Study

Tripathi¹

2022

ARR

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Nuclear factor-kappa B (NF-B), a transcription factor, was called after its ability to bind to the enhancer element of the immunoglobulin kappa light-chain of B cells [7]. It is an important inflammatory inducible factor that regulates the transcription of a number of pro inflammatory cytokines, chemokines, and adhesion molecules to mediate the inflammatory response. Punicalagin, for example, inhibits lipopolysaccharide (LPS)induced neuroinflammation, oxidative stress, and memory loss by blocking NF-kB activation [8]. urthermore, when the NF-B signaling pathway is engaged, secreted inflammatory cytokines and chemokines such as IL-1, IL-6, and TNF-α have been shown to have important effects on the course of ALI. Another study confirms that NF-B activation can speed up the transcription of IL-1, . TLR-4 plays a role in a variety of inflammatory diseases, including ischemic heart disease and

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“…The severity of lung injury in ARDS patients was linked to serum cytokine and chemokine levels [5]. Infected epithelial cells release cytokines, which attract leukocytes, macrophages, and nearby endothelial cells, causing an increase in cytokine and chemokine production and the symptom known as cytokine storm [6].…”

Section: Introductionmentioning

confidence: 99%

"Bio Actives from Albizia Lebbeck on Acute Lung Injury/ Acute Respiratory Distress Syndrome Molecular Targets: In-Silico Study"

Tripathi

2022

BJSTR

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This contemporary work is prepared with the aim of presenting natural phytoconstituents obtained from Albizia lebbeck (Bronco T) as a remedial option against Acute Lung Injury / Acute Respiratory Distress Syndrome (ARDS). The early onset of non-cardiogenic edema and subsequent gas-exchange impairment caused by a severe inflammatory process known as cytokine storm is Acute Respiratory Distress Syndrome (ARDS). The existing strategy includes mechanical ventilation and glucocorticosteroid. However they pose problems like diaphragm atrophy and down regulated immune response of the host In the lungs of patients with Acute Respiratory Distress Syndrome (ARDS), the nuclear regulatory factor NF-kappaB and TLR-4 is activated, which may contribute to increased expression of immune regulatory cytokines and other pro inflammatory mediators including IL-6 and TNF-alpha. Natural products play a pivotal role as it offers minimal and in some cases no toxicity. Albizia lebbeck is known as Sirisha in the folk language and is known for its antiinflammatory properties. Targeting the above mentioned receptors with bioactives from Albizia lebbeck would down regulate the signaling pathway and its associated mediators in ARDS. Through in-silico study including molecular docking, ADMET and Lipinski analysis, we are trying to narrow down the active phytoconstituent from Albizia lebbeck against ARDS.

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Recent insight into potential acute respiratory distress syndrome

Cited by 8 publications

References 54 publications

Lung Ultrasound and Respiratory Pathophysiology in Mechanically Ventilated COVID-19 Patients—an Observational Trial

Lung Ultrasound and Respiratory Pathophysiology in Mechanically Ventilated COVID-19 Patients—an Observational Trial

Bio Actives from Albizia Lebbeck on Acute Lung Injury/ Acute Respiratory Distress Syndrome Molecular Targets: In-Silico Study

"Bio Actives from Albizia Lebbeck on Acute Lung Injury/ Acute Respiratory Distress Syndrome Molecular Targets: In-Silico Study"

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