Recent innovations in non-invasive brain stimulation (NIBS) for the treatment of unipolar and bipolar depression: a narrative review

Piccoli, Eleonora; Cerioli, M.; Castiglioni, Michele; Larini, L.; Scarpa, Carolina; Dell’Osso, Bernardo

doi:10.1080/09540261.2022.2132137

Cited by 5 publications

(3 citation statements)

References 63 publications

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“…Indeed, in recent years, NIBS techniques have been promising in the treatment of various pathological conditions that require the modulation of brain networks, e.g., depression and substance addiction [ 41 , 42 ]. Considering that they are safe and well-tolerated, interest in their application is growing, particularly in pathological contexts, where usual treatments are ineffective or even unavailable [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Cortical Responses after Transcranial Direct Current Stimulation in Disorders of Consciousness: An Exploratory Study

Straudi,

Antonioni,

Baroni

et al. 2023

JCM

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Disorders of consciousness (DoC) due to severe traumatic brain injury (TBI) are associated with severe disability and an alteration of cortical activation, angiogenesis, and inflammation, which are crucial elements for behavioural recovery. This exploratory study aimed to evaluate anti-inflammatory and cortical responses after transcranial direct current stimulation (tDCS) in traumatic prolonged disorders of consciousness. Ten minimally conscious state (MCS) patients underwent ten sessions of anodal tDCS (five sessions/week, two weeks, 40 min/session) on the primary motor cortex bilaterally. Clinical evaluations were performed using the Coma Recovery Scale–Revised (CRS-R) pre- and post-treatment. In contrast, after single and multiple tDCS sessions, the haemodynamic cortical response was obtained with functional near-infrared spectroscopy (fNIRS). Moreover, angiogenesis (angiopoietin-2, BMP9, endoglin, HbEFG, HGF, IL8, Leptin, PLGF, VEGF-A, and VEGF-C) and inflammation (GM-CSF, IFNg, IP10, MCP1, and TNFα) circulating biomarkers were collected. A significant haemodynamic response was observed after a single tDCS session, with an increased activation from 4.4 (3.1–6.1) to 7.6 (2.9–15.7) a.u. (p = 0.035). After ten tDCS sessions, a significant reduction of angiopoietin-2, VEGF-C, and IP-10 was detected. Moreover, a correlation between behavioural (CRS-R), TNFα (r = 0.89; p = 0.007), and IP10 (r = 0.81; p = 0.014) variation was found. In conclusion, a single tDCS session can increase the cortical activation in MCS patients. Moreover, multiple tDCS sessions showed an anti-inflammatory effect related to behavioural improvement.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Cortical Responses after Transcranial Direct Current Stimulation in Disorders of Consciousness: An Exploratory Study

Straudi,

Antonioni,

Baroni

et al. 2023

JCM

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“…Transcranial magnetic stimulation and transcranial direct and alternating current stimulations are considered to be the most developed NIBS techniques [1-3], so are rhythmic sensory stimulation (acoustic, video-and audiovisual) [4][5][6]. NIBS techniques enable to achieve improved outcomes in neurological rehabilitation of neurologic patients [7][8][9][10][11][12], in cognitive and stress-induced impairments [13][14][15][16][17][18], when treating psychiatric disorders [19][20][21][22][23][24], and in enhancing cognitive functions in healthy people [25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Brain State-Dependent Non-Invasive Neurostimulation with EEG Feedback: Achievements and Prospects

Fedotchev,

Zemlyanaya

2023

Sovrem Tehnol Med

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Non-invasive brain stimulation with electroencephalogram (EEG) feedback is an intensively developing and promising area of neurophysiology. The review considers the literature data over the past 5 years on the achievements and promising directions for the further development of this research line. Modern data on the developed approaches to the practical use of various types of brain state-dependent adaptive neurostimulation with EEG feedback were analyzed. The main attention is paid to the studies using non-invasive magnetic and electrical stimulation, as well as acoustic and audiovisual stimulation. The paper considers the possibilities and prospects for using these technologies in clinical medicine. The results of the authors' own research are presented.

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“…Non-invasive brain stimulation (NIBS) paradigms are used for a variety of purposes, including attempted treatment of several psychiatric conditions (e.g. major depressive disorder [1,2], schizophrenia [3], bipolar disorder [4]), and investigating neural oscillation properties and controllability [5][6][7]. Despite reported clinical efficacy, many questions remain about the mechanisms involved [8] as well as how to optimize their use.…”

Section: Introductionmentioning

confidence: 99%

Morphological variability may limit single-cell specificity to electric field stimulation

Trotter

Pariz

Hutt

et al. 2023

Preprint

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Non-invasive brain stimulation techniques are widely used for manipulating the behaviour of neuronal circuits and the excitability of the neurons therein. While the usage of these techniques is widely studied at the meso- and macroscopic scales, less is known about the specificity of such approaches at the level of individual cells. Here we use models based on the morphologies of real pyramidal and parvalbumin neurons from mouse primary visual cortex created by the Allen Institute for Brain Science to explore the variability and evoked response susceptibility of different morphologies to uniform electric fields. We devised a range of metrics quantifying various aspects of cellular morphology, ranging from whole cell attributes to net compartment length, branching, diameter to orientation. In supporting layer- and cell-type specific responses, none of these physical traits passed statistical significance tests. While electric fields can modulate somatic, dendritic and axonal compartments reliably and subtype-specific responses could be observed, the specificity of such stimuli was blurred by the variability in cellular morphology. These null results suggest that morphology alone may not account for the reported subtype specificity of brain stimulation paradigms, and question the extent to which such techniques may be used to probe and control neural circuitry.

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Recent innovations in non-invasive brain stimulation (NIBS) for the treatment of unipolar and bipolar depression: a narrative review

Cited by 5 publications

References 63 publications

Anti-Inflammatory and Cortical Responses after Transcranial Direct Current Stimulation in Disorders of Consciousness: An Exploratory Study

Anti-Inflammatory and Cortical Responses after Transcranial Direct Current Stimulation in Disorders of Consciousness: An Exploratory Study

Brain State-Dependent Non-Invasive Neurostimulation with EEG Feedback: Achievements and Prospects

Morphological variability may limit single-cell specificity to electric field stimulation

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