Recent Innovations in Non-dairy Prebiotics and Probiotics: Physiological Potential, Applications, and Characterization

Khan, Fasiha Fayyaz; Sohail, Aamir; Ghazanfar, Shahina A.; Ahmad, Asif; Riaz, Abid; Abbasi, Kashif Sarfraz; Ibrahim, Muhammad Sohail; Uzair, Mohammad; Arshad, Muhammad Umair

doi:10.1007/s12602-022-09983-9

Cited by 13 publications

(5 citation statements)

References 207 publications

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“…Probiotics are mainly isolated from dairy products, fermented foods, fruits, vegetables, soil, and healthy human feces (Khan et al., 2023). In addition to basic nutrients, immune cells, and other bioactive molecules that are suitable for infant development, breast milk also contains various microbes, including bacteria and fungi (Stinson et al., 2021).…”

Section: Discussionmentioning

confidence: 99%

Probiotic properties and the ameliorative effect on DSS‐induced colitis of human milk–derived Lactobacillus gasseri SHMB 0001

Wang,

Dong,

Liu

et al. 2024

Journal of Food Science

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Human milk contains a variety of microorganisms that exert benefit for human health. In the current study, we isolated a novel Lactobacillus gasseri strain named Lactobacillus gasseri (L. gasseri) SHMB 0001 from human milk and aimed to evaluate the probiotic characteristics and protective effects on murine colitis of the strain. The results showed that L. gasseri SHMB 0001 possessed promising potential probiotic characteristics, including good tolerance against artificial gastric and intestinal fluids, adhesion to Caco‐2 cells, susceptibility to antibiotic, no hemolytic activity, and without signs of toxicity or infection in mice. Administration of L. gasseri SHMB 0001 (1 × 108 CFU per gram of mouse weight per day) reduced weight loss, the disease activity index, and colon shortening in mice during murine colitis conditions. Histopathological analysis revealed that L. gasseri SHMB 0001 treatment attenuated epithelial damage and inflammatory infiltration in the colon. L. gasseri SHMB 0001 treatment increased the expression of colonic occludin and claudin‐1 while decreasing the expression of pro‐inflammatory cytokine genes. L. gasseri SHMB 0001 modified the composition and structure of the gut microbiota community and partially recovered the Clusters of Orthologous Groups (COG) and Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways altered by dextran sulfate sodium (DSS). Overall, our results indicated that the human breast milk–derived L. gasseri SHMB 0001 exhibited promising probiotic properties and ameliorative effect on DSS‐induced colitis in mice. L. gasseri SHMB 0001 may be applied as a promising probiotic against intestinal inflammation in the future.Practical ApplicationL. gasseri SHMB 0001 isolated from human breast milk showed good tolerance to gastrointestinal environment, safety, and protective effect against DSS‐induced mice colitis via enforcing gut barrier, downregulating pro‐inflammatory cytokines, and modulating gut microbiota. L. gasseri SHMB 0001 may be a promising probiotic candidate for the treatment of intestinal inflammation.

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Section: Discussionmentioning

confidence: 99%

Probiotic properties and the ameliorative effect on DSS‐induced colitis of human milk–derived Lactobacillus gasseri SHMB 0001

Wang,

Dong,

Liu

et al. 2024

Journal of Food Science

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“…Probiotics can heal inflamed periodontal tissues as they release antioxidants that can counter the reactive oxygen species (Ardila et al, 2022). However, one should note that, unlike antibiotics which show their effect in a short time, the effects of probiotics will occur slowly and upon prolonged administration (Khan et al, 2022;Wang et al, 2017;Yoon & Yoon, 2018;Zdarta & Kaczorek, 2023). Therefore probiotics cannot immediately reduce PI and GI scores, unlike antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of probiotics compared to antibiotics to treat periodontal disease: Systematic review

Puzhankara,

Banerjee,

Chopra

et al. 2023

Oral Diseases

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ObjectivesProbiotics are promising adjuncts to non‐surgical periodontal therapy (scaling and root planing (SRP)) for managing gingival and periodontal diseases. Probiotics are considered alternatives to antibiotics, especially with the emergence of antimicrobial resistance. Hence, the present systematic review aims to generate evidence on the role of probiotics compared to antimicrobial agents for managing periodontal diseases (gingivitis and periodontitis).MethodSix electronic databases (PubMed, SCOPUS, Web of Science, EBSCO, Cochrane, Clinical Trial Registry) were searched to collect studies comparing the effect of probiotics with antibiotics for periodontal disease. In total, 5530 articles were retrieved from all databases, of which 1891 were included for title and abstract screening. After screening, a total of ten clinical studies were included for data extraction and analysis. Probing pocket depth (PPD), Clinical attachment loss (CAL), bleeding on probing (BOP), plaque index (PI), gingival index (GI), and microbial profile were recorded.ResultsProbiotics showed a significant reduction in the PPD and CAL compared to antibiotics. Antibiotics were more effective in reducing the PI and GI. A combination of probiotics and antibiotics superior compared to probiotics and antibiotics alone.ConclusionProbiotics can be used as an alternative to antibiotics, however, a combination is more effective for managing periodontal disease.

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“…Neural pathways connecting the gut and bone contribute to the bilateral communication between these systems. Sensory nerves in the gut can relay signals to the central nervous system, influencing the release of neurotransmitters that impact bone cells [95–106,107 ▪ ]. GM can indirectly influence hormones and growth factors involved in bone metabolism, such as modulating insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta (TGF-β).…”

Section: Mechanisms Of Interaction Between the Gastrointestinal Micro...mentioning

confidence: 99%

The interaction between gut microbiome and bone health

Inchingolo,

Piras

et al. 2024

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review This review critically examines interconnected health domains like gut microbiome, bone health, interleukins, chronic periodontitis, and coronavirus disease 2019 (COVID-19), offering insights into fundamental mechanisms and clinical implications, contributing significantly to healthcare and biomedical research. Recent findings This review explores the relationship between gut microbiome and bone health, a growing area of study. It provides insights into skeletal integrity and potential therapeutic avenues. The review also examines interleukins, chronic periodontitis, and COVID-19, highlighting the complexity of viral susceptibility and immune responses. It highlights the importance of understanding genetic predispositions and immune dynamics in the context of disease outcomes. The review emphasizes experimental evidence and therapeutic strategies, aligning with evidence-based medicine and personalized interventions. This approach offers actionable insights for healthcare practitioners and researchers, paving the way for targeted therapeutic approaches and improved patient outcomes. Summary The implications of these findings for clinical practice and research underscore the importance of a multidisciplinary approach to healthcare that considers the complex interactions between genetics, immune responses, oral health, and systemic diseases. By leveraging advances in biomedical research, clinicians can optimize patient care and improve health outcomes across diverse patient populations.

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Recent Innovations in Non-dairy Prebiotics and Probiotics: Physiological Potential, Applications, and Characterization

Cited by 13 publications

References 207 publications

Probiotic properties and the ameliorative effect on DSS‐induced colitis of human milk–derived Lactobacillus gasseri SHMB 0001

Probiotic properties and the ameliorative effect on DSS‐induced colitis of human milk–derived Lactobacillus gasseri SHMB 0001

Effectiveness of probiotics compared to antibiotics to treat periodontal disease: Systematic review

The interaction between gut microbiome and bone health

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