Recent hot topics in contrast media

Thomsen, Henrik S.

doi:10.1007/s00330-010-2026-x

Cited by 15 publications

(7 citation statements)

References 32 publications

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“…Detected signals were reviewed to identify previously unlabeled AEs. Due to the close attention to contrast induced nephropathy (19), an additional analysis was performed for renal AEs. In this analysis, AEs were classified into two groups: renal AEs and non-renal AEs.…”

Section: Methodsmentioning

confidence: 99%

Comparison of the Safety of Seven Iodinated Contrast Media

et al. 2013

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We aimed to determine the characteristic adverse events (AEs) of iodinated contrast media (IOCM) and to compare the safety profiles of different IOCM. This study used the database of AEs reports submitted by healthcare professionals from 15 Regional Pharmacovigilance Centers between June 24, 2009 and December 31, 2010 in Korea. All reports of IOCM, including iopromide, iohexol, iopamidol, iomeprol, ioversol, iobitridol and iodixanol, were analyzed. Safety profiles were compared between different IOCM at the system organ level using the proportional reporting ratio (PRR) and 95% confidence interval (95% CI). Among a total of 48,261 reports, 6,524 (13.5%) reports were related to the use of IOCM. Iopromide (45.5%), iohexol (16.9%), iopamidol (14.3%) and iomeprol (10.3%) were identified as frequently reported media. 'Platelet, bleeding & clotting disorders' (PRR, 29.6; 95%CI, 1.9-472.6) and 'urinary system disorders' (PRR, 22.3; 95% CI, 17.1-29.1) were more frequently reported for iodixanol than the other IOCM. In conclusion, the frequency of AEs by organ class was significantly different between individual media. These differences among different IOCM should be considered when selecting a medium among various IOCM and when monitoring patients during and after its use to ensure optimum usage and patient safety.

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Section: Methodsmentioning

confidence: 99%

Comparison of the Safety of Seven Iodinated Contrast Media

et al. 2013

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“…Among these, two of the T1-shortening contrast agents have liver-specific characteristics: gadoxetic acid (Primovist®) and gadobenate dimeglumine (MultiHance®). These contrast agents have to be administered intravenously and contain gadolinium, which increases the risk of nephrogenic systemic fibrosis (NSF) in patients with low glomerular filtration rate (GFR) [6]. …”

Section: Introductionmentioning

confidence: 99%

MRI of colorectal cancer liver metastases: comparison of orally administered manganese with intravenously administered gadobenate dimeglumine

et al. 2011

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ObjectivesTo compare the sensitivity of MRI to detect colorectal cancer liver metastases (CRLM) after ingestion of manganese-based contrast agent (CMC-001) with that of a comprehensive intravenous gadobenate dimeglumine protocol, and to assess the safety and acceptability of oral manganese.Methods20 patients suspected of having 1–6 CRLM were included prospectively in this randomised cross-over study. Liver MRI was performed with a one-week interval at 1.5 T and included T1-w VIBE and T2-HASTE, before and after administration of 1.6 g CMC-001 or 0.1 mmol/kg gadobenate dimeglumine. The metastasis-to-liver signal intensity (SI) ratio was calculated. Standard of reference was histopathology after surgery, or combination of other imaging studies and/or follow up. Adverse events (AE) and clinicolaboratory tests were monitored.ResultsOf 44 metastases, 41 were detected after CMC-001 (93%) and 42 after gadobenate dimeglumine (95%). Fifteen false–positive lesions were found after CMC-001 and 2 after gadobenate dimeglumine. The metastasis-to-liver SI ratio was significantly higher after CMC-001 than after gadobenate dimeglumine (0.51 and 0.21 respectively, P < 0.0001). More AE occurred after manganese compared to gadobenate dimeglumine.ConclusionsCMC-001 is as sensitive as an extensive intravenous gadobenate dimeglumine protocol in detecting CRLM. It was relatively well tolerated but had higher rates of gastrointestinal AE.Key Points• Liver MRI after ingestion of manganese is highly sensitive for detecting metastases• High false–positive rate necessitates further evaluation, in some cases• The MR examination time is short• Oral ingestion of manganese seems safe and relatively well tolerated by patients• Manganese compounds may be useful for liver metastasis surveillance after colorectal cancer

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“…These T1w-Gd protocols simultaneously provide vascular and tissue contrast via a single acquisition, thereby reducing scan time and avoiding registration errors, and permit surgical planning using a single data set. However, the injection of gadolinium contrast has some associated medical risks (for example, uncommon nephropathy or systemic fibrosis, local skin reactions, and rare systemic allergy) 30,31,33 and cost. Most importantly, gadolinium contrast only achieves visualization of large vessels as the contrast decreases rapidly in smaller vessels due to partial volume averaging with surrounding tissue.…”

confidence: 99%

Neuronavigation using susceptibility-weighted venography: application to deep brain stimulation and comparison with gadolinium contrast

Bériault¹,

Sadikot

AlSubaie

et al. 2014

JNS

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Careful trajectory planning on preoperative vascular imaging is an essential step in deep brain stimulation (DBS) to minimize risks of hemorrhagic complications and postoperative neurological deficits. This paper compares 2 MRI methods for visualizing cerebral vasculature and planning DBS probe trajectories: a single data set T1-weighted scan with double-dose gadolinium contrast (T1w-Gd) and a multi-data set protocol consisting of a T1-weighted structural, susceptibility-weighted venography, and time-of-flight angiography (T1w-SWI-TOF). Two neurosurgeons who specialize in neuromodulation surgery planned bilateral STN DBS in 18 patients with Parkinson's disease (36 hemispheres) using each protocol separately. Planned trajectories were then evaluated across all vascular data sets (T1w-Gd, SWI, and TOF) to detect possible intersection with blood vessels along the entire path via an objective vesselness measure. The authors' results show that trajectories planned on T1w-SWI-TOF successfully avoided the cerebral vasculature imaged by conventional T1w-Gd and did not suffer from missing vascular information or imprecise data set registration. Furthermore, with appropriate planning and visualization software, trajectory corridors planned on T1w-SWI-TOF intersected significantly less fine vasculature that was not detected on the T1w-Gd (p < 0.01 within 2 mm and p < 0.001 within 4 mm of the track centerline). The proposed T1w-SWI-TOF protocol comes with minimal effects on the imaging and surgical workflow, improves vessel avoidance, and provides a safe cost-effective alternative to injection of gadolinium contrast.

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Recent hot topics in contrast media

Cited by 15 publications

References 32 publications

Comparison of the Safety of Seven Iodinated Contrast Media

Comparison of the Safety of Seven Iodinated Contrast Media

MRI of colorectal cancer liver metastases: comparison of orally administered manganese with intravenously administered gadobenate dimeglumine

Neuronavigation using susceptibility-weighted venography: application to deep brain stimulation and comparison with gadolinium contrast

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