Abstract:This review summarizes the literatures dealing with the synthesis of some important nitrogen or nitrogen/sulfur heterocyclic, spiroheterocyclic, and fused heterocyclic compounds.
“…The mechanism was described as due to nucleophilic attacked of 54a–d , j to the C═C double bond of 44 followed by elimination of a molecule of malononitrile to form first intermediate 203a–e (Scheme ). Then intramolecular nucleophilic attack of NH to the carbonyl group to give second intermediate 204a–e was followed by elimination of H 2 O to provide thioxoindenotriazines 205a–e (Scheme ) .…”
The inherent reactivity of thiocarbohydrazides and thiosemicarbazides makes them valuable as building blocks for the synthesis of other heterocyclic motifs. This review article discusses the recent applications of classes of compounds in syntheses of five‐membered to seven‐membered heterocycles of biological activities and remarkable number of metal complexes. Many previous reviews dealt with the reactivity of either thiosemicarbazides or thiocarbohydrazides. However, a large number of publications have recently dealt with the reactivity of thiosemicarbazides and thiocarbohydrazides. Consequently, we have found that it is of importance to shed new light on these interesting molecules.
“…The mechanism was described as due to nucleophilic attacked of 54a–d , j to the C═C double bond of 44 followed by elimination of a molecule of malononitrile to form first intermediate 203a–e (Scheme ). Then intramolecular nucleophilic attack of NH to the carbonyl group to give second intermediate 204a–e was followed by elimination of H 2 O to provide thioxoindenotriazines 205a–e (Scheme ) .…”
The inherent reactivity of thiocarbohydrazides and thiosemicarbazides makes them valuable as building blocks for the synthesis of other heterocyclic motifs. This review article discusses the recent applications of classes of compounds in syntheses of five‐membered to seven‐membered heterocycles of biological activities and remarkable number of metal complexes. Many previous reviews dealt with the reactivity of either thiosemicarbazides or thiocarbohydrazides. However, a large number of publications have recently dealt with the reactivity of thiosemicarbazides and thiocarbohydrazides. Consequently, we have found that it is of importance to shed new light on these interesting molecules.
Recent Heterocyclic Compounds from (1,3-Dioxo-2,3-dihydro-1H-inden--2-ylidene)propanedinitrile -[59 refs.]. -(HASSAN*, A. A.; MOSTAFA, S. M.; J. Heterocycl. Chem. 51 (2014) 6, 1545-1557, http://dx.
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