Recent heart rate history affects QT interval duration in atrial fibrillation

Riad, Fady S.; Razak, Eathar; Saba, Samir; Shalaby, Alaa; Němec, Jan

doi:10.1371/journal.pone.0172962

Cited by 9 publications

(13 citation statements)

References 29 publications

(33 reference statements)

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“…Moreover, it affirms the importance of RR of the first preceding beat in determining QT (this also has been found on a class of exponentially weighted models in Ref. 22 . The RR→QT transfer, being a direct measure of QT dependence on RR, is affected by the mutual QT/RR configuration.…”

Section: Qt-rr Coupling Configurationssupporting

confidence: 84%

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Information transfer in QT-RR dynamics: Application to QT-correction

Potapov

Latukka

Kim

et al. 2018

Preprint

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The relation between the electrical properties of the heart and the beating rate is essential for the heart functioning. This relation is central when calculating the "corrected QT interval" -an important measure of the risk of potentially lethal arrhythmias. We use the transfer entropy method from information theory to quantitatively study the mutual dynamics of the ventricular action potential duration (the QT interval) and the length of the beat-to-beat (RR) interval. We show that for healthy individuals there is a strong asymmetry in the information transfer: the information flow from RR to QT dominates over the opposite flow (from QT to RR), i.e. QT depends on RR to a larger extent than RR on QT. Moreover, the history of the intervals has a strong effect on the information transfer: at sufficiently long QT history length the information flow asymmetry inverts and the RR influence on QT dynamics weakens. Finally, we demonstrate that the widely used QT correction methods cannot properly capture the changes in the information flows between QT and RR. We conclude that our results obtained through a model-free informational perspective can be utilised to improve and test the QT correction schemes in clinics. 2/123/12

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Section: Qt-rr Coupling Configurationssupporting

confidence: 84%

“…In the literature, other attempts have been made to quantify the dynamic QT-RR coupling 4,22,[36][37][38] . These approaches rely on statistical models of the given form and, thus, have assumptions behind the models.…”

Section: Discussionmentioning

confidence: 99%

Information transfer in QT-RR dynamics: Application to QT-correction

Potapov

Latukka

Kim

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…Moreover, it affirms the importance of RR of the first preceding beat in determining QT (this also has been found on a class of exponentially weighted models in ref. 22 ).…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, recent evidence demonstrates improvements in the QT correction procedures when a range of the past values of HR is taken into account 4 , 21 , 22 . The correction improvement is especially profound in patients with atrial fibrillation, where HR values are unpredictable 23 , 24 .…”

Section: Introductionmentioning

confidence: 99%

Information transfer in QT-RR dynamics: Application to QT-correction

Potapov

Latukka

Kim

et al. 2018

Sci Rep

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The relation between the electrical properties of the heart and the beating rate is essential for the heart functioning. This relation is central when calculating the “corrected QT interval” — an important measure of the risk of potentially lethal arrhythmias. We use the transfer entropy method from information theory to quantitatively study the mutual dynamics of the ventricular action potential duration (the QT interval) and the length of the beat-to-beat (RR) interval. We show that for healthy individuals there is a strong asymmetry in the information transfer: the information flow from RR to QT dominates over the opposite flow (from QT to RR), i.e. QT depends on RR to a larger extent than RR on QT. Moreover, the history of the intervals has a strong effect on the information transfer: at sufficiently long QT history length the information flow asymmetry inverts and the RR influence on QT dynamics weakens. Finally, we demonstrate that the widely used QT correction methods cannot properly capture the changes in the information flows between QT and RR. We conclude that our results obtained through a model-free informational perspective can be utilised to improve and test the QT correction schemes in clinics.

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“…The current literature contains several studies [24][25][26][27][28][29][30] on HRV in different clinical scenarios and environments. However, within the hospital environment, and specifically during the weaning process of mechanical ventilation, the findings are still not well understood.…”

Section: Discussionmentioning

confidence: 99%

Modulação autonômica cardíaca durante diferentes modos de desmame em ventilação mecânica

Guerra

Zangirolami-Raimundo

Sarmento³

et al. 2019

jhgd

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Introdução: A variabilidade da frequência cardíaca (VFC) é um método não invasivo para analisar variações de intervalos de tempo entre batimentos cardíacos. A VFC é um método promissor para analisar o balanço autonômico quantitativamente. Durante o processo de desmame da ventilação mecânica, ocorrem alterações na atividade autonômica. Objetivo: Analisar o comportamento da modulação autonômica da frequência cardíaca em diferentes modos do desmame da VM. Método: 18 pacientes foram estudados. Os parâmetros cardiorrespiratórios (PAS, PAD, PAM, FR, SpO2) iniciais e finais foram registrados em uma ficha. Um cardiofrequencimetro foi posicionado (relógio no punho e cinta no tórax). Os pacientes foram mantidos em decúbito Fowler e permaneceram 10’ em cada modo ventilatório (A/C, SIMV, PSV 18 e 10 e nebulização com Tubo T). Os sinais captados pelo cardiofrequencimetro foram analisados através do software Kubios®. Resultados: Os parâmetros da Variabilidade da Frequência Cardíaca foram analisados nos domínios do tempo, frequência e índices geométricos. Houve aumento na média rMSSD - modulação parassimpática, do momento A/C para o momento PSV 10 (p=0,027), aumento entre os momentos SIMV e PSV 10 (p=0,042), mas reduziu entre os momentos PSV 10 e TUBO T (p=0,035). Houve aumento na média do LF (low frequency) -modulação simpática, dos momentos SIMV e PSV 10 para TUBO T (p=0,011 e p=0,037). A média de LF apresentou queda entre os momentos A/C e SIMV (p=0,024), aumento nos momentos SIMV e PSV 10 para TUBO T (p =0,049 e p=0,027). HF (high frequency) - modulação simpática aumentou entre os momentos SIMV e PSV 10 (p=0,020) e também entre os momentos SIMV e TUBO T (p=0,044). Houve redução na média HF entre os momentos PSV e TUBO T (p=0,026). Conclusão: Modos controlados apresentaram diminuição da VFC e maior predomínio simpático em relação a modos espontâneos.

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Recent heart rate history affects QT interval duration in atrial fibrillation

Cited by 9 publications

References 29 publications

Information transfer in QT-RR dynamics: Application to QT-correction

Information transfer in QT-RR dynamics: Application to QT-correction

Information transfer in QT-RR dynamics: Application to QT-correction

Modulação autonômica cardíaca durante diferentes modos de desmame em ventilação mecânica

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