Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms

Huang, Biqing; Wang, Jianwei; Li, Lanjuan

doi:10.1186/s13099-023-00547-y

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…This interaction between the host and gut microbes is posited to be a central determinant of these immune responses [52]. Both clinical cases and animal models have demonstrated the ability of the gut microbial community to influence the effectiveness of vaccines [62]. This emerging knowledge holds the potential to be harnessed for the enhancement of therapeutic vaccination strategies through deliberate manipulation of the gut microbiota.…”

Section: Immune Modulationmentioning

confidence: 99%

Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era

Wang,

Ju,

Zeng

2024

Biomedicines

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The human gut microbiota, comprising trillions of microorganisms residing in the gastrointestinal tract, has emerged as a pivotal player in modulating various aspects of human health and disease. Recent research has shed light on the intricate relationship between the gut microbiota and pharmaceuticals, uncovering profound implications for drug metabolism, efficacy, and safety. This review depicted the landscape of molecular mechanisms and clinical implications of dynamic human gut Microbiota-Drug Interactions (MDI), with an emphasis on the impact of MDI on drug responses and individual variations. This review also discussed the therapeutic potential of modulating the gut microbiota or harnessing its metabolic capabilities to optimize clinical treatments and advance personalized medicine, as well as the challenges and future directions in this emerging field.

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Section: Immune Modulationmentioning

confidence: 99%

Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era

Wang,

Ju,

Zeng

2024

Biomedicines

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“…In addition, SARS‐CoV‐2 replication requires certain key enzymes, and regulation of the abundance of bacterial flora and its metabolite concentrations by probiotics may affect related processes and improve vaccine efficacy. 184 , 185 , 186 The research and use of SARS‐CoV‐2 intranasal spray vaccine have attracted increasing attention. Considering the characteristics of upper respiratory tract flora changes after virus infection and its potential function in regulating the virus and immune microenvironment, further exploration of the role of flora and the mechanisms of immune regulation is imperative for developing and using related vaccines.…”

Section: Microbiota‐based Implications For Therapeutic Interventionsmentioning

confidence: 99%

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Qiu,

Mo,

Chen

et al. 2024

MedComm

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 million deaths. Patients with coronavirus disease (COVID‐19) may suffer from diarrhea, sleep disorders, depression, and even cognitive impairment, which is associated with long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients with COVID‐19 have alterations in microbiota and their metabolites, particularly in the gut, which may be involved in the regulation of immune responses. Consumption of probiotics may alleviate the discomfort caused by inflammation and oxidative stress. However, the pathophysiological process underlying the alleviation of COVID‐19‐related symptoms and complications by targeting the microbiota remains unclear. In the current study, we summarize the latest research and evidence on the COVID‐19 pandemic, together with symptoms of SARS‐CoV‐2 and vaccine use, with a focus on the relationship between microbiota alterations and COVID‐19‐related symptoms and vaccine use. This work provides evidence that probiotic‐based interventions may improve COVID‐19 symptoms by regulating gut microbiota and systemic immunity. Probiotics may also be used as adjuvants to improve vaccine efficacy.

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“…The role of gut microbial populations has been considered in the formulation of vaccine regimes. This is because dysbiosis may impair vaccination efficacy by affecting the immunological milieu and how the immune system reacts to vaccine antigens ( Huang et al., 2023 ; Mańkowska-Wierzbicka et al., 2023 ). Dysbiosis causes systemic repercussions that migrate beyond the gut environment and cause infection in other organs.…”

Section: Clinical Studies On Gut Microbiotamentioning

confidence: 99%

“…Thus, a healthy gut microbiota may aid in the resolution of inflammation and avoidance of chronic immune activation when the body recovers from the viral induced disease. Additional, immune memory has been related to the gut microbiome and is critical for efficiently responding to future infections or immunisations ( Huang et al., 2023 ). Tissue repair and healing have also been linked to certain gut flora and their metabolites.…”

Section: Post Covid-19 Immune Responses Of Gut Microbiotamentioning

confidence: 99%

COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

Raj,

Bruce,

Anbalagan

et al. 2024

Front. Cell. Infect. Microbiol.

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The novel coronavirus disease 2019 (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has garnered unprecedented global attention. It caused over 2.47 million deaths through various syndromes such as acute respiratory distress, hypercoagulability, and multiple organ failure. The viral invasion proceeds through the ACE2 receptor, expressed in multiple cell types, and in some patients caused serious damage to tissues, organs, immune cells, and the microbes that colonize the gastrointestinal tract (GIT). Some patients who survived the SARS-CoV-2 infection have developed months of persistent long-COVID-19 symptoms or post-acute sequelae of COVID-19 (PASC). Diagnosis of these patients has revealed multiple biological effects, none of which are mutually exclusive. However, the severity of COVID-19 also depends on numerous comorbidities such as obesity, age, diabetes, and hypertension and care must be taken with respect to other multiple morbidities, such as host immunity. Gut microbiota in relation to SARS-CoV-2 immunopathology is considered to evolve COVID-19 progression via mechanisms of biochemical metabolism, exacerbation of inflammation, intestinal mucosal secretion, cytokine storm, and immunity regulation. Therefore, modulation of gut microbiome equilibrium through food supplements and probiotics remains a hot topic of current research and debate. In this review, we discuss the biological complications of the physio-pathological effects of COVID-19 infection, GIT immune response, and therapeutic pharmacological strategies. We also summarize the therapeutic targets of probiotics, their limitations, and the efficacy of preclinical and clinical drugs to effectively inhibit the spread of SARS-CoV-2.

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Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms

Cited by 8 publications

References 39 publications

Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era

Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

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