Recent findings and applications of biomedical engineering for COVID-19 diagnosis: a critical review

Bui, Le Minh; Phung, Huong Thi Thu; Thi, Thuy-Tien Ho; Singh, Vijai; Maurya, Rupesh; Khambhati, Khushal; Wu, Chin-Shan; Uddin, Jamal; Trung, Do Minh; Chu, Dinh Toi

doi:10.1080/21655979.2021.1987821

Cited by 11 publications

(9 citation statements)

References 227 publications

(168 reference statements)

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“…The recent COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (also known as nCoV-2 or SARS-CoV-2) has become an important global health problem in the last three years because it is responsible for more than 6.5 million ( https://www.worldometers.info/coronavirus ) deaths worldwide and enormous economic and social limitations [ 59 ]. However, the antiviral drug Veklury (remdesivir) has been approved for the treatment of patients (Oct 2020); Some others, such as monoclonal antibody therapies, have been approved through the emergency use authorization (EUA) [ 60 ].…”

Section: Clinical Applications Of the Crispr Systemmentioning

confidence: 99%

An Update on the Application of CRISPR Technology in Clinical Practice

et al. 2023

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The CRISPR/Cas system, an innovative gene-editing tool, is emerging as a promising technique for genome modifications. This straightforward technique was created based on the prokaryotic adaptive immune defense mechanism and employed in the studies on human diseases that proved enormous therapeutic potential. A genetically unique patient mutation in the process of gene therapy can be corrected by the CRISPR method to treat diseases that traditional methods were unable to cure. However, introduction of CRISPR/Cas9 into the clinic will be challenging because we still need to improve the technology's effectiveness, precision, and applications. In this review, we first describe the function and applications of the CRISPR–Cas9 system. We next delineate how this technology could be utilized for gene therapy of various human disorders, including cancer and infectious diseases and highlight the promising examples in the field. Finally, we document current challenges and the potential solutions to overcome these obstacles for the effective use of CRISPR–Cas9 in clinical practice.

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Section: Clinical Applications Of the Crispr Systemmentioning

confidence: 99%

An Update on the Application of CRISPR Technology in Clinical Practice

et al. 2023

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“…However, these studies were mainly cross-sectional studies and lacked sound study design to evaluate the intervention measures and could not analyze the causal relationship between the measures and WPV or PVV ( 17 ). In addition, COVID-19 is one of the most severe global health crises that humanity has ever faced ( 19 ). Relevant studies have focused on the impact of the IPC measures on occupational infections in HWs, psychological distress, and WPV ( 20 ), but fewer studies have specifically examined PVV and its trends.…”

Section: Instructionmentioning

confidence: 99%

Effects of infection prevention and control measures on patient and visitor violence against health workers in China during COVID-19 pandemic

Cheng

Huang

2023

Front. Public Health

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ObjectiveTo examine trends in patient and visitor violence (PVV) among large public hospitals from 2016 to 2020 in China, and investigate the effects of infection prevention and control (IPC) measures on PVV during the COVID-19 pandemic.MethodsThe hospital-level data of PVV used in this study from 2016 to 2020 in three cities in northern China were extracted from the database of the Medical Quality and Safety Notification System from 41 public hospitals. The difference-in-difference (DID) method was used to estimate the effects of IPC measures on PVV. The empirical strategy was to compare changes in the incidence rate of PVV in public hospitals where IPC measures were stricter to relatively weaker hospitals.ResultsFrom 2019 to 2020, the incidence rate of PVV decreases from 4.59 to 2.15% for high-IPC measure level hospitals and increases from 4.42 to 4.56% for medium-IPC measure level hospitals. The results from the DID models showed that as the IPC measure level increased, the incidence rate of PVV (β = −3.12, 95% CI = −5.74 ~ −0.50) decreased more significantly based on controlling for hospital fixed effects and time trends.ConclusionThe multi-dimensional and comprehensive IPC measures throughout the pandemic in China have not only controlled the pandemic, but also directly or indirectly reduced the incidence rate of PVV by alleviating the stress of health workers and the crowded working environment, creating a good order of admission, and reducing patient waiting time.

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“…The ongoing COVID-19 pandemic has emphasized the importance of diagnostic testing in outbreak control [ 44 , 45 ]. Efforts to end the COVID-19 pandemic require the accurate utilization of diagnostic testing in high volumes and the rapid use of the results to help implement the appropriate therapy and policy, preventing further disease spread [ 46 ]. Conducting such high throughput diagnostic tests is challenging, especially in areas with limited health personnel and infrastructures.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Update on the Development of Toehold Switch-Based Approach for Molecular Diagnostic Tests of COVID-19

Geraldi

Puspaningsih

Khairunnisa

2022

Journal of Nucleic Acids

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A high volume of diagnostic tests is needed during the coronavirus disease 2019 (COVID-19) pandemic to obtain representative results. These results can help to design and implement effective policies to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Diagnosis using current gold standard methods, i.e., real-time quantitative PCR (RT-qPCR), is challenging, especially in areas with limited trained personnel and health-related infrastructure. The toehold switch-based diagnostic system is a promising alternative method for detecting SARS-CoV-2 that has advantages such as inexpensive cost per testing, rapid, and highly sensitive and specific analysis. Moreover, the system can be applied to paper-based platforms, simplifying the distribution and utilization in low-resource settings. This review provides insight into the development of toehold switch-based diagnostic devices as the most recent methods for detecting SARS-CoV-2.

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Recent findings and applications of biomedical engineering for COVID-19 diagnosis: a critical review

Cited by 11 publications

References 227 publications

An Update on the Application of CRISPR Technology in Clinical Practice

An Update on the Application of CRISPR Technology in Clinical Practice

Effects of infection prevention and control measures on patient and visitor violence against health workers in China during COVID-19 pandemic

Update on the Development of Toehold Switch-Based Approach for Molecular Diagnostic Tests of COVID-19

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