Recent field effect transistors and electrical impedance spectroscopy based biosensing strategies for cancer biomarker screening: A mini review

Chakraborty, Ananya; Dutta, Priyanka; Wakankar, A.; RoyChaudhuri, C.

doi:10.1016/j.biosx.2022.100253

Cited by 4 publications

(6 citation statements)

References 38 publications

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“…In the last decades, multiple technologies have been developed to facilitate these processes and reduce their costs. [164] For example, nanotechnologies were employed to aid the diagnosis of oral cancer, [135] breast cancer, [165] prostate cancer, [165] and ovarian cancer. [166] There is a vast literature on cancer diagnostics based on fluorescence, [87,167,168] colorimetry, [133] chemoluminescence, [169] surface enhanced Raman scattering (SERS), [170] surface charge sensing, [91] and electrochemical sensing, [165,171] to detect nucleicacids, [172] aptamers, [173,174] and other cancer biomarkers.…”

Section: Cancer Diagnostics Based On Electricitymentioning

confidence: 99%

“…[166] There is a vast literature on cancer diagnostics based on fluorescence, [87,167,168] colorimetry, [133] chemoluminescence, [169] surface enhanced Raman scattering (SERS), [170] surface charge sensing, [91] and electrochemical sensing, [165,171] to detect nucleicacids, [172] aptamers, [173,174] and other cancer biomarkers. [175] These involve the employment of different materials and devices, including nanoparticles, [135,174,176,177] field-effect transistors, [164] and 2D materials. [178][179][180] In this review, selected recent advancements are presented based on their action mechanisms which involve cancer bioelectricity.…”

Section: Cancer Diagnostics Based On Electricitymentioning

confidence: 99%

“…The nanoparticle-cell complex is designed such to exhibit optical properties which allow its selective visualization using imaging techniques, including magnetic resonance imaging (MRI) or computed tomography (CT) scanning. [87,164,183] (iii) Sensing. Charged nanoparticles can also be used to detect cancer biomarkers.…”

Section: Cancer Diagnostics Based On Electricitymentioning

confidence: 99%

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Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

Moreddu

2023

Advanced Science

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Bioelectricity is the electrical activity that occurs within living cells and tissues. This activity is critical for regulating homeostatic cellular function and communication, and disruptions of the same can lead to a variety of conditions, including cancer. Cancer cells are known to exhibit abnormal electrical properties compared to their healthy counterparts, and this has driven researchers to investigate the potential of harnessing bioelectricity as a tool in cancer diagnosis, prognosis, and treatment. In parallel, bioelectricity represents one of the means to gain fundamental insights on how electrical signals and charges play a role in cancer insurgence, growth, and progression. This review provides a comprehensive analysis of the literature in this field, addressing the fundamentals of bioelectricity in single cancer cells, cancer cell cohorts, and cancerous tissues. The emerging role of bioelectricity in cancer proliferation and metastasis is introduced. Based on the acknowledgement that this biological information is still hard to access due to the existing gap between biological findings and translational medicine, the latest advancements in the field of nanotechnologies for cellular electrophysiology are examined, as well as the most recent developments in micro‐ and nano‐devices for cancer diagnostics and therapy targeting bioelectricity.

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Section: Cancer Diagnostics Based On Electricitymentioning

confidence: 99%

Section: Cancer Diagnostics Based On Electricitymentioning

confidence: 99%

Section: Cancer Diagnostics Based On Electricitymentioning

confidence: 99%

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Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

Moreddu

2023

Advanced Science

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“…Biosensors have emerged as a crucial component in clinical point-of-care diagnosis [1,2], which works by converting biological responses into electrical signals [3,4]. Here, there are two approaches for detection of the analytes: the labeled technique [5,6], and the unlabeled technique [7,8]. Amongst the labeled methods, the use of nanoparticle-based tags to achieve enhanced sensitivity [9] changes the inherent nature of the infected cells and requires extra time and expense [10].…”

Section: Introductionmentioning

confidence: 99%

A negative capacitance field effect transistor with a modified gate stack and drain-side cavity for label-free biosensing

Kansal,

Medury

2024

Semicond. Sci. Technol.

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Dielectrically modulated (DM) Negative Capacitance Field Effect Transistor (NCFET) based label-free Biosensors have emerged as promising devices for accurate detection of various biomolecules, where the sensitivity of DM architectures strongly depends on the sensing mechanism as well as on the size of the nano-cavity. Therefore, to achieve higher sensitivity along with reduced fabrication complexity, we propose to utilize a pre-existing drain-sided spacer region as a nano-cavity, in a Fully Depleted Silicon-on-insulator (FDSOI) based NCFET architecture. The Ferroelectric (FE) layer in the Metal-Ferroelectric-Insulator-Semiconductor (MFIS) configuration meaningfully alters the impact of drain's electric field on the source-sided electrostatics, which results in higher sensitivity. Having quantified the sensitivity for an FE-DE gate stack based NCFET Biosensor, we now propose to include a Paraelectric (PE) layer between Ferroelectric (FE) and Dielectric (DE) materials, thus modifying the gate stack from FE-DE to FE-PE-DE with an equivalent negative capacitance seen from both the stacks, where a remarkable improvement is seen in the FE-PE-DE gate stack based NCFET with nearly identical linearity performance as seen from the high value of Pearson's coefficient (r2 ≥ 0.9). Therefore, in order to illustrate the efficacy of the proposed sensing mechanism and the modified gate stack (FE-PE-DE), dielectric constant (kBio) values in the range of kBio = 4.5 to kBio = 75.99 are considered. Finally, the effect of scaling the channel length (Lg) on the sensitivity of the FE-PE-DE NCFET device is shown and a high value, particularly at lower permittivity, demonstrates the versatility and wide applicability of the proposed NCFET Biosensor.

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“…Prostate-specific antigen (PSA) has been used as a serum marker for detecting prostate cancer, which not only offers great diagnostic benefits in assisting with staging and early detection but also plays an important role in preventing cancer from developing. 1,2 Although commonly used detection methods, including immunofluorescence technology, radioimmunoassay, enzyme-linked immunosorbent assay, have greatly facilitated the development of antigen detection biology, [3][4][5] the inherent shortcomings, such as complex operation, expensive instruments, long reaction time, and poor stability, hinder their widespread applications. Recently, biosensors based on extended-gate transistors with excellent device performance have been developed for highly sensitive detection of antigen molecule concentrations.…”

Section: Introductionmentioning

confidence: 99%

Electrolyte-gated amorphous IGZO transistors with extended gates for prostate-specific antigen detection

Yin,

Ji,

Liu

et al. 2024

Lab Chip

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Recent field effect transistors and electrical impedance spectroscopy based biosensing strategies for cancer biomarker screening: A mini review

Cited by 4 publications

References 38 publications

Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

A negative capacitance field effect transistor with a modified gate stack and drain-side cavity for label-free biosensing

Electrolyte-gated amorphous IGZO transistors with extended gates for prostate-specific antigen detection

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