Although insight into the structure of our Galaxy can be sought in various ways, study of the radio emission from the neutral hydrogen component is particularly suitable. Neutral atomic hydrogen, HI, is the main observed constituent of the interstellar medium; its physical properties are closely related to the properties of other Galactic constituents, both stellar and interstellar. The interstellar medium is transparent enough to hydrogen emission at the 21-cm radio wavelength that investigation of the entire Galaxy is possible, with the exception of a few directions along the Galactic equator. This transparency allows investigation of regions of the Galaxy which are too distant to be studied optically. HI is particularly important for the information it provides on the form and overall mass in the outer Galaxy, where it is the only directly observable constituent. Interstellar neutral hydrogen is so abundant and is distributed in such a general fashion throughout the Galaxy that the 21-cm hyperfine transition line has been detected in emission in every direction in the sky at which a suitably equipped radio telescope has been pointed. No time variation of a neutral hydrogen line has been found.The 21-cm line of atomic hydrogen results from a hyperfine transition in the ground state of the atom. This state is characterized by two possible relative orientations of the spins of the electron and proton; when the spins are parallel the energy of the system is slightly greater than when they are antiparallel. The energy separation between the two hyperfine sublevels corresponds to a quantum of radiation with a natural frequency of 1420.406 MHz. The probability that this spin-flip transition from the F = 1 to the F = 0 state will occur spontaneously is given by the Einstein emission coefficient, A 10 = 2.85 X to-15 S-1. Thus a spontaneous electron spin flip would occur after some eleven million years. In fact, atomic encounter collisions largely determine the relative populations of the two energy levels. At the typical HI densities of about 0.4 em -3 which characterize much of interstellar space, encounters result in reorientation of the spins of a hydrogen atom about once every three or four hundred years. Effects of ambient interstellar radiation field on the spin states are less important than those of encounters, except in certain unusual interstellar environments such as found near recent supernovae or near regions of intense star formation.