Recent Evidence-Based Clinical Guide for the Use of Dinutuximab Beta in Pediatric Patients with Neuroblastoma

Abstract

The anti-GD2 antibody dinutuximab beta (Qarziba ® ) has been added to the present standard of care for patients with highrisk neuroblastoma in Europe based on the positive results obtained in different studies. In both the first-line and relapsed/ refractory settings, treatment with dinutuximab beta attains objective clinical responses in children with high-risk neuroblastoma. Its incorporation has changed the outcome for these patients and optimized management should be guaranteed to minimize possible adverse effects. Most prevalent adverse events include pain, allergic reactions, fever and capillary leak syndrome. There are still no evidence-based clinical guidelines that include the latest published evidence to optimize its use, as it depends on the experience gained in each referral center. Topics such as the mode of preparation and administration, the concomitant use of interleukin-2, the recommended pediatric age and dose for its use, or the adequate management of possible toxicities are important aspects to review. The objective of this article was to update the clinical guide to management with dinutuximab beta of children with neuroblastoma based on the most recent published evidence and our own experience in clinical practice.

Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review

“…Neuroblastoma tumour microenvironment and cytotoxic action induced by anti-GD2. [71] Reproduced from [73] and recreated with Bio-Render.com. https://www.nature.com/articles/nrm2510 cofactors and are homologues of the yeast protein Sir2.…”

“… Neuroblastoma tumour microenvironment and cytotoxic action induced by anti‐GD2 [71] . Reproduced from [73] and recreated with BioRender.com.…”

Cost‐effectiveness analysis of dinutuximab β for the treatment of high‐risk neuroblastoma in China

“…In this study, the treatment strategies were based on the authoritative researches 7,8 and NB guidelines. 16 Furthermore, traditional therapy with isotretinoin (TT group) and add-on treatment with dinutuximab β (GD2 group) were compared.…”