The future evolution of the Antarctic Ice Sheet represents the largest uncertainty in sea-level projections of this and upcoming centuries. Recently, satellite observations and high-resolution simulations have suggested the initiation of an ice-sheet instability in the Amundsen Sea sector of West Antarctica, caused by the last decades' enhanced basal ice-shelf melting. Whether this localized destabilization will yield a full discharge of marine ice from West Antarctica, associated with a global sea-level rise of more than 3 m, or whether the ice loss is limited by ice dynamics and topographic features, is unclear. Here we show that in the Parallel Ice Sheet Model, a local destabilization causes a complete disintegration of the marine ice in West Antarctica. In our simulations, at 5-km horizontal resolution, the region disequilibrates after 60 y of currently observed melt rates. Thereafter, the marine ice-sheet instability fully unfolds and is not halted by topographic features. In fact, the ice loss in Amundsen Sea sector shifts the catchment's ice divide toward the Filchner-Ronne and Ross ice shelves, which initiates grounding-line retreat there. Our simulations suggest that if a destabilization of Amundsen Sea sector has indeed been initiated, Antarctica will irrevocably contribute at least 3 m to global sea-level rise during the coming centuries to millennia.West Antarctic Ice Sheet | sea-level rise | tipping point | instability | marine ice-sheet instability T he Antarctic Ice Sheet is losing mass at an accelerating rate, and thus increasingly contributes to global sea-level rise (1,2). To what extent this is caused by anthropogenic warming of the atmosphere is unclear. The Amundsen Sea sector of West Antarctica accounts for the largest part of the ice loss, manifesting in a speed-up, thinning, and retreat of tributaries such as Pine Island Glacier and Thwaites Glacier during the last 4 decades (3-5). Large portions of the West Antarctic Ice Sheet (WAIS) are grounded on bedrock below sea level (6, 7). These so-called marine parts of the ice sheet hold an ice volume that would elevate global mean sea level by about 3.3 m (8). The bed below this marine ice is generally down-sloping in the inland direction. A grounding line (the line that separates the grounded ice sheet from the floating ice shelf) that is located on such bed has been shown to be potentially unstable (9, 10). The associated marine ice-sheet instability (i.e., self-sustained ice-sheet retreat) can be hindered by the buttressing of ice shelves, which has been investigated in different modeling frameworks (11)(12)(13)(14).The recently inferred destabilization of the Amundsen Sea sector coincides with an increase in the volume and temperature of relatively warm circumpolar deep water that reaches into the ice-shelf cavities in the Amundsen Sea (15, 16). The resulting substantially enhanced sub-ice-shelf melting facilitated the retreat of the grounding line of several tributaries onto the potentially unstable down-sloping bed section. Complex, high...