Recent Discovery and Development of Inhibitors that Target CDK9 and Their Therapeutic Indications
Yuming Zhang,
Lianhai Shan,
Wentao Tang
et al.
Abstract:CDK9
is a cyclin-dependent kinase that plays pivotal roles in multiple
cellular functions including gene transcription, cell cycle regulation,
DNA damage repair, and cellular differentiation. Targeting CDK9 is
considered an attractive strategy for antitumor therapy, especially
for leukemia and lymphoma. Several potent small molecule inhibitors,
exemplified by TG02 (4), have progressed
to clinical trials. However, many of them face challenges such as
low clinical efficacy and multiple adverse reactions and may … Show more
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