Recent developments on polysaccharide-based chiral stationary phases for liquid-phase separation of enantiomers

Chiral Pharmaceuticals in Diverse Environmental Matrices: Occurrence, Removal and Toxicity

“…93 A Cromatografia Líquida com FEQ (Figura 4) tem tido uma elevada reputação na separação enantiosseletiva, tanto no modo analítico como preparativo. [93][94][95] Há muitos tipos de colunas quirais comerciais, recentemente revistas na literatura. 93 111 sendo importante ter em conta a variação da FE na sua biodegradação e/ou remoção nas ETE, uma vez que os microrganismos podem degradar ambos os enantiômeros de forma não enantiosseletiva ou podem degradar seletivamente um enantiômero, além de poderem efetuar modificações que levam à formação de metabolitos/produtos de transformação quirais a partir de substratos aquirais.…”

The Preparation of a New Protein Based HPLC Column Packing Material and Enantiomeric Resolution of Some Pharmaceutical Related Compounds via This Column

“…Bu polisakkaritlerin asit klorürler ve izosiyanatlarla reaksiyonu sonucu oluşan ester ya da karbamatları kiral tanıma özelliğine sahiptir. Polisakkarit temelli CSP'ler, birçok kiral bileşiğin enantiyomerik rezolüsyonunda yaygın olarak kullanılmaktadır [6,12,34,39].…”

Liquid Chromatographic Resolution of Fendiline and Its Analogues on a Chiral Stationary Phase Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid

“…Various liquid chromatographic CSPs have been applied to the determination of enantiomeric composition of chiral compounds [5,6]. For example, CSPs based on polysaccharide derivatives [7], cyclodextrines [8], macrocyclic antibiotics [9,10], cyclofrutanes [11], chiral crown ethers [11][12][13][14] and other small molecules [15] were quite successful for the resolution of racemic compounds. However, liquid chromatographic enantioseparation of fendiline on CSPs is quite rare.…”

“…Fendiline also contains a secondary amino group and, in this instance, it is expected to be resolved on CSP 1. In this study, we wish to report the resolution of fendiline and its analogues (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) shown in Figure 2 on CSP 1.…”