Recent developments of nanomedicine delivery systems for the treatment of pancreatic cancer

Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers

“…Being asymptomatic in the early stages, this disease is often discovered quite late. Moreover, pancreatic cancer treatment is impeded by the inaccessible anatomical position of this organ and the inability of chemotherapeutic agents to penetrate the dense extracellular matrix surrounding pancreatic tumor cells [ 9 , 127 , 128 , 129 ]. This unfortunate context has led to the prediction that, by 2030, pancreatic cancer will become the second leading cause of cancer death in the absence of better-suited therapeutics [ 9 ].…”

“…In this respect, a plethora of nanomaterials have been researched for biocompatible delivery systems for anticancer drugs [5,7]. Including chemoth in engineered nanovehicles is promising for reducing unwanted cytotoxicity, solubility and stability, and ensuring controlled and sustained drug release [9 One attractive alternative to designing carriers for anticancer medicines im cyclodextrins. These cyclic oligosaccharides of natural origin are recognized fo profile, ability to encapsulate various moieties within their cavity, and the po facile chemical modification [1,5].…”

“…In this respect, a plethora of nanomaterials have been researched for fabricating biocompatible delivery systems for anticancer drugs [ 5 , 7 ]. Including chemotherapeutics in engineered nanovehicles is promising for reducing unwanted cytotoxicity, improving solubility and stability, and ensuring controlled and sustained drug release [ 9 , 10 ].…”