Recent developments of functional magnetic resonance imaging research for drug development in Alzheimer's disease

Hampel, Harald; Prvulovic, David; Teipel, Stefan J.; Bokde, Arun L.W.

doi:10.1016/j.pneurobio.2011.05.012

Cited by 23 publications

(12 citation statements)

References 109 publications

(96 reference statements)

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“…Functional MRI studies have also consistently implicated the DMN as the most vulnerable network in AD [30, 31]. The posterior (temporo-parietal-predominant) DMN may be particularly susceptible in early-stage AD [32–34]. These studies therefore support our findings that a significant correlation exists between CBF and cognition, in the PCC and IPL.…”

Section: Discussionsupporting

confidence: 87%

Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study

et al. 2017

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BackgroundTo analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer’s disease (AD).MethodsForty-one patients diagnosed with AD or mild cognitive impairment due to AD were recruited for this study. CBF images were obtained using ASL-MRI (n = 41) with a post-labeling delay (PLD) of 1.5 and 2.5 s (PLD1.5 and PLD2.5, respectively) using a 3 T scanner, in addition to brain perfusion SPECT with N-isopropyl-4-[I-123]iodoamphetamine (n = 28). Voxel-based analyses were performed for ASL-MRI and SPECT using Mini-Mental State Examination (MMSE) scores as covariates. Differences in CBF between PLD1.5 and PLD2.5 were assessed using a paired t-test with SPM12.ResultsSignificant positive correlations were observed between MMSE scores and CBF at PLD1.5 in the right posterior cingulate cortex (PCC), and both temporo-parietal association cortexes. At PLD2.5, significant positive correlations were determined for MMSE scores and CBF in the superior parietal lobule and the right temporo-parietal association cortex. SPECT showed significant positive correlations in the PCC and both temporo-parietal association cortexes (right-side dominant). PLD1.5 showed significantly higher CBF than PLD2.5 in the proximal areas of vascular territories of the anterior, middle, and posterior cerebral arteries.ConclusionsSignificant positive correlations in CBF, measured with both ASL-MRI and SPECT, with cognition were found in the PCC and temporo-parietal association cortexes. PLD1.5 and PLD2.5 showed similar correlations with cognition, although the CBF images had significant differences.

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Section: Discussionsupporting

confidence: 87%

Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study

et al. 2017

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“…The advent of neuroimaging techniques such as EEG [48,49] , magnetoencephalography [19,50] , MRI [51,52] , functional MRI (fMRI) [53,54] , structural MRI (sMRI) have increased the study of cognitive neuroscience. They facilitate the noninvasive research of human brain mechanism and study of its complex connectivity [55,56] .…”

Section: Eeg-based Diagnosis Of Admentioning

confidence: 99%

Clinical Neurophysiological and Automated EEG-Based Diagnosis of the Alzheimer's Disease

Bhat¹,

Acharya

Dadmehr³

et al. 2015

Eur Neurol

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Alzheimer's disease (AD) is a progressive disorder affecting intellectual, behavioral and functional abilities. It is associated with age and pathological alterations leading to the formation of amyloid plaques and tangles. It is the most common source of dementia in the older population, which varies in its degrees of severity. We are yet to find efficient methods of diagnosis of AD, as its symptoms vary among individuals. This paper presents a review of recent research on the clinical neurophysiological and automated electroencephalography-based diagnosis of the AD. Various therapeutic measures are also discussed briefly.

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“…Importantly, this will allow for the application of preventive measures at the earliest and potentially fully reversible stages of disease inception. Moreover, functional neuroimaging may offer potentially unprecedented possibilities to develop mechanism independent surrogate markers that will serve to accurately predict clinical outcome in interventional trials and AD drug development (Hampel et al, 2011b; Ewers et al, 2011). Of note, while backed up by substantial and evergrowing body of evidence, these functional neuroimaging markers await confirmation and validation from longitudinal studies as well as from clinicopathological studies with autopsy-verified diagnosis.…”

mentioning

confidence: 99%

Neurodegenerative disease biomarkers: Guideposts for disease prevention through early diagnosis and intervention

Trojanowski

Hampel

2011

Progress in Neurobiology

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Recent developments of functional magnetic resonance imaging research for drug development in Alzheimer's disease

Cited by 23 publications

References 109 publications

Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study

Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study

Clinical Neurophysiological and Automated EEG-Based Diagnosis of the Alzheimer's Disease

Neurodegenerative disease biomarkers: Guideposts for disease prevention through early diagnosis and intervention

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