Recent Developments in the Use of Nitrates for Treatment of Angina Pectoris

Abstract

Organic nitrates are effective in the treatment and prophylaxis of angina pectoris. The major clinical problem of tolerance may be avoided if the daily plasma concentrations of the active metabolite, isosorbide-5-mononitrate are maintained at 100-300 ng/ml. The most promising development in achieving this is the use of sustained release preparations.

A Review of Clinical Influencing Factors in the Selection of Cardiac Medications in the Elderly

“…Nitrates are effective in preventing and treating angina pectoris [15]. These medications also treat other heart conditions such as ischemia, heart failure, MI, and hypertension emergencies [16].…”