Recent developments in the treatment of migraine in children and adolescents

Freitag, Frederick G.; Schloemer, Fallon; Shumate, Derrick

doi:10.4172/2472-1913.100009

Cited by 6 publications

(7 citation statements)

References 65 publications

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“…In the United States, more than 28% people are suffering from migraine headache (2). The triptans and nonsteroidal anti-inflammatory drugs have been found to provide a symptomatic relief in migraine (3). Rizatriptan benzoate is a selective 5-hydroxytriptamine (5-HT) 1B/1D receptor agonist which is used for the acute treatment of migraine in adults with or without aura (4).…”

Section: Introductionmentioning

confidence: 99%

Taste Masked Oral Fast Dissolving Sublingual Strips of Rizatriptan Benzoate for Migraine Therapy

Mali¹,

Dias²,

Ghorpade³

et al. 2017

Marmara Pharmaceutical Journal

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The aim of present investigation was to develop a taste masked fast dissolving sublingual strips of rizatriptan benzoate. The fast dissolving strips (FDS) were prepared by solvent casting method using polyox N-10 and polyethylene glycol 400 (PEG 400) as polymer and plasticizer respectively. The FDS were evaluated for pH, folding endurance, tensile strength, moisture absorption, disintegration time and in vitro dissolution. All formulations were free from bubble and exhibited smooth appearance. The pH of the films was acidic. It was observed that increase in the concentration of polyox N-10 increased the disintegration time but reduced the dissolution rate. The formulation A2 showed all the evaluation parameters within the acceptable range and was considered as optimized formulation. The optimized formulation was subjected to the taste masking and stability study. The results of taste masking study indicated an efficient masking of the bitter taste of drug by the flavouring agents in the film. The formulation A2 was found to be stable for three months with an insignificant change in the drug content and mean dissolution time (MDT). The compatibility study performed using ATR-FTIR and DSC analysis indicated absence of any unusual interaction between drug and excipients used in formulation. Thus, the FDS comprised of polyox N-10 and PEG 400 may be a better alternative to the other available fast dissolving systems for delivery of rizatriptan benzoate.

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Section: Introductionmentioning

confidence: 99%

Taste Masked Oral Fast Dissolving Sublingual Strips of Rizatriptan Benzoate for Migraine Therapy

Mali¹,

Dias²,

Ghorpade³

et al. 2017

Marmara Pharmaceutical Journal

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“…According to the American Migraine Prevalence and Prevention (AMPP) Study, approximately 12% of adults suffer with migraine in the United States . And it is thought to be prevalent in up to 10% of the pediatric population . This often debilitating neurological condition also carries high disability.…”

Section: My Pickmentioning

confidence: 99%

A Review of Complementary and Alternative Medicine Use Among U.S. Adults with Headache or Migraine: Results from the 2012 National Health Interview Survey

Krasenbaum

2017

Headache

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“…Pharmacologic therapy can be helpful in treating and preventing chronic headaches . However, medications alone are not consistently effective at preventing headache in children and adolescents .…”

Section: Introductionmentioning

confidence: 99%

“…5 Pharmacologic therapy can be helpful in treating and preventing chronic headaches. 6 However, medications alone are not consistently effective at preventing headache in children and adolescents. 7 Prior studies suggest that nonmedical therapy is an important component of care, particularly in patients with significant disability due to headache.…”

Section: Introductionmentioning

confidence: 99%

Group Education and Multidisciplinary Management for Chronic Headaches Among Adolescents in a Military Treatment Facility: A Retrospective Chart Review

et al. 2018

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Recent developments in the treatment of migraine in children and adolescents

Cited by 6 publications

References 65 publications

Taste Masked Oral Fast Dissolving Sublingual Strips of Rizatriptan Benzoate for Migraine Therapy

Taste Masked Oral Fast Dissolving Sublingual Strips of Rizatriptan Benzoate for Migraine Therapy

A Review of Complementary and Alternative Medicine Use Among U.S. Adults with Headache or Migraine: Results from the 2012 National Health Interview Survey

Group Education and Multidisciplinary Management for Chronic Headaches Among Adolescents in a Military Treatment Facility: A Retrospective Chart Review

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