Recent Developments in the Transformation of 3-amino-2-azetidinones

Abstract

Functionalized 3-amino-2-azetidinones are important heterocyclic systems which can easily be transformed into functionally decorated heterocycles using β-lactam synthon protocol. The different synthetic methods have been explored for the transformation of functionalized 3-amino-2-azetidiones to various heterocyclic molecules, such as imidazolidin-2-ones, piperazines, hydantoins, 4-oxo-1H-pyrroles, 1,4-benzodiazepin2-ones, amino pyrrolidine-2-carboxylates etc., and β-lactam- based conjugates having diverse biological activities, such as anti-malarial activity, anti-tuberculosis, anti-trichomonas activity etc. The present review article summarizes the various reports on the synthetic transformation of functionalized 3-amino-2-azetidinones for the synthesis of a variety of heterocyclic systems.