Recent developments in the significant effect of mRNA modification (M6A) in glioblastoma and esophageal cancer

Akinlalu, Alfred Olaoluwa; Njoku, Prisca Chinonso; Nzekwe, Chisom Vivian; Oni, Rukayat Olayemi; Fojude, Toyosi; Faniyi, Akinwale John; Olagunju, Abolaji Samson

doi:10.1016/j.sciaf.2022.e01347

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 141 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 48 XRN1 is involved in transcription, mRNA translation, and mRNA decay, and its modification plays a crucial role in post-transcriptional and translational activities that promote tumor development and chemoresistance. 18 , 48 , 49 Therefore, changes in the availability of the XRN1 protein and alterations in mRNA metabolism can lead to anomalous mRNA accumulation in PDAC tumor cells, which may trigger inflammatory responses and/or necrosis. 19 , 48 Thus, we consider XRN1 protein as the potential therapeutic target of AA treatment, complementary to the targets for GEM.…”

Section: Discussionmentioning

confidence: 99%