Recent Developments in the Photochemical Synthesis of Functionalized Imidazopyridines

Abstract

Imidazopyridines constitute one of the most important scaffolds in medicinal chemistry, as their skeleton could be found in a myriad of biologically active molecules. Although numerous strategies were elaborated for imidazopyridine preparation in the 2010s, novel eco-compatible synthetic approaches have emerged, conscious of climate change concerns. In this framework, photochemical methods have been promoted to conceive this heterocyclic motif over the last decade. This review covers the recently published works on synthesizing highly functionalized imidazopyridines by light induction.

Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review

“…Photocatalytic reactions have been applied with metallic or metal-free catalysts for the synthesis and functionalization of IZPs. Tran et al, 2022, reviewed the literature on recent advancements in the photochemical synthesis of IZPs [ 56 ].…”

C(sp2)‐H Imination of Imidazo[1,2‐a]pyridines: A Catalyst‐Free, Multicomponent Approach

“…[9] Consequently, several synthetic methodologies are developed to construct this fascinating framework. [10][11] Particularly, C3-functionalized imidazo [1,2a]pyridines were of special interest (see Figure 1).…”

“…Therefore, notable developments in C3‐functionalization of imidazo[1,2‐ a ]pyridines using various catalysts, such as photochemical approach, [11a] radical‐mediated functionalization, [11b] metal‐free, [10e] and transition‐metal free approaches were developed [11d] . These C−H functionalization strategies of imidazopyridines include alkylation, arylation, aroyl methylation, hydroxy‐alkylation, thio‐carbamation, aminomethylation, sulfonylation, thio‐cyanation, selenization, halogenation, amination, trifluoromethylation, sulfenylation, carbonylation, and selenocyanation.…”

A practical perspective for chromatic orthogonality for implementing in photolithography

“…Before beginning any synthetic endeavor, the absorption spectrum can be computationally determined using quantum chemistry techniques like density functional theory (DFT). Information from the absorption spectrum alone cannot forecast the wavelength at which photochemical reaction pathways can be most successfully activated [6][7][8] .…”