Recent developments in the etiology, treatment, and potential therapeutic targets for Parkinson's disease: a focus on biochemistry

Chaudhary, Sapana; Chaudhary, Sameer; Rawat, Sakshi; Natesan, Saieswari; Pardeshi, Tanvee; Alexiou, Athanasios; Ashraf, Ghulam Md

doi:10.1016/b978-0-12-815946-0.00005-3

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Neurodegenerative Disorders and Their Association With Mitoc...1

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2022

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“…PD is the second common neurodegenerative disorder that affects the serotonergic, adrenergic, and dopaminergic systems, causing a depletion in the neurotransmitters of the respective systems developing defective motor non-motor coordination [ 104 - 106 ]. Studies suggest the role of mutation of various variants, including α-synuclein, Leucine-rich repeat kinase 2 (LRRK 2), glucocerebrosidase gene (GBA), microtubule-associated protein τ (MAPT), MDR1, Parkin, and PINK1 [ 87 , 88 ].…”

Section: Neurodegenerative Disorders and Their Association With Mitoc...mentioning

confidence: 99%

The Role of Mitochondrial Genes in Neurodegenerative Disorders

Kumar

Harila

Parambi

et al. 2022

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: Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and Stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains unclear in depth.

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