Recent developments in the clinical application of thyroid cancer biomarkers

Shibru, Daniel; Chung, Ki-Wook; Kebebew, Electron

doi:10.1097/cco.0b013e3282f27e49

Cited by 56 publications

(44 citation statements)

References 47 publications

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“…The most common genetic alterations occurring in thyroid cancers are related with signal transduction pathways, including tyrosine kinase receptors [RET/PTC and neurotrophic tyrosine receptor kinase (NTRK)], signaling proteins (BRAF and RAS), and nuclear proteins [paired box (PAX) 8 and peroxisome proliferator-activated receptor γ (PPAR-γ)] (Vriens et al, 2009). These genetic changes are always mutually exclusive (Shibru et al, 2008) and have something to show about the deregulated miRNAs.…”

Section: Correlation Of Somatic Mutations With Deregulated Mirna Exprmentioning

confidence: 99%

Deregulation of microRNA expression in thyroid tumors

Yuan

Yang

Zheng

2014

J. Zhejiang Univ. Sci. B

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MicroRNAs (miRNAs or miRs) are endogenous non-coding RNAs that negatively regulate gene expression by binding to the 3' non-coding regions of target mRNAs, resulting in their cleavage or blocking their translation. miRNAs may have an impact on cell differentiation, proliferation, and survival, and their deregulation can be inclined to diseases and cancers, including thyroid tumors. The purpose of this review is to summarize the existing findings of deregulated miRNAs in different types of thyroid tumors and to exhibit their potential target genes, especially to demonstrate those involved in tumor invasion and metastasis. In addition, new findings of circulating miRNA expression profiles, single nucleotide polymorphism (SNP) in thyroid tumors, and the correlation of somatic mutations with deregulated miRNA expression in thyroid tumors were all included in this review.

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Section: Correlation Of Somatic Mutations With Deregulated Mirna Exprmentioning

confidence: 99%

Deregulation of microRNA expression in thyroid tumors

Yuan

Yang

Zheng

2014

J. Zhejiang Univ. Sci. B

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“…Until a few years ago, thyroid carcinoma was believed to originate from well-differentiated normal thyroid follicular cells as a consequence of multiple mutations accumulated throughout the entire life span (17). More recently, the existence of several degrees of differentiation has lead to the assumption that a pool of stem cells at different stages of differentiation are responsible for thyroid cancer initiation and progression.…”

Section: Introductionmentioning

confidence: 99%

Tumorigenic and Metastatic Activity of Human Thyroid Cancer Stem Cells

et al. 2010

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“…In the past decade, the incidence of thyroid cancer has increased by 2.3-fold with annual rates of 5.4% in men and 6.5% in women (Siegel et al, 2014). Most thyroid cancers are derived from follicular cells, and consist of conventional papillary thyroid carcinoma (PTC), follicular variant of PTC (FPTC), follicular thyroid carcinoma (FTC), Hürthle cell thyroid carcinomas, and anaplastic thyroid carcinoma (ATC) (Shibru et al, 2008;Vriens et al, 2009;Pallante et al, 2010). The diagnostic rate of thyroid nodules is over 7% in the adult population; however, most thyroid nodules are benign, and only 5% of thyroid nodules are proven to be malignant (Dean and Gharib, 2008).…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis

Zhou¹,

Xiao²,

Zhao³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). The summary receiver-operating characteristic curve (SROC) and area under the SROC curve (AUC) were used to further evaluate the overall diagnostic value. Overall, 20 studies from 7 articles, including 266 thyroid cancer patients and 277 controls with benign thyroid disease, were available for analysis. The pooled sensitivity, specificity, PLR, NLR, and DOR were: 0. 7279-7289 (2015) 0.95 versus 0.82, suggesting that the multiple miRNA assay is a more credible method for thyroid cancer detection. In summary, miRNA assays, especially multiple miRNA assays, may play an important role as a second-line diagnostic tool to improve the diagnostic accuracy of fine needle aspiration biopsy in indeterminate lesions. However, further studies are warranted to confirm our findings.

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Recent developments in the clinical application of thyroid cancer biomarkers

Cited by 56 publications

References 47 publications

Deregulation of microRNA expression in thyroid tumors

Deregulation of microRNA expression in thyroid tumors

Tumorigenic and Metastatic Activity of Human Thyroid Cancer Stem Cells

MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis

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