Recent Developments in the Area of Click‐Crosslinked Nanocarriers for Drug Delivery

Dai, Yu; Chen, Xin; Zhang, Xiaojin

doi:10.1002/marc.201800541

Cited by 13 publications

(13 citation statements)

References 113 publications

(149 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This eliminates the additional synthetic steps of labelling the material. These photoclick reactions have also found applications in drug delivery owing to their faster kinetics and specificity [82] . This strategy enables drug encapsulation without undergoing any side reactions.…”

Section: Applicationsmentioning

confidence: 99%

Click Chemistry Mediated by Photochemical Energy

Arora

Singh

2022

ChemistrySelect

View full text Add to dashboard Cite

Light mediated chemical reactions have emerged as an important class of reactions known as photoclick reactions. These reactions have allowed synthesis of complex molecular structures to be performed under mild conditions. The spatiotemporal control offered by photoclick reactions cannot be achieved by thermal processes. This review captures the advances in the area of photoclick chemistry and highlights the importance of light induced cycloaddition reactions, thiol‐ene/yne reactions and hetero‐Diels–Alder reactions.

show abstract

Section: Applicationsmentioning

confidence: 99%

Click Chemistry Mediated by Photochemical Energy

Arora

Singh

2022

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…[15] Advancements of cross-linking strategies have enabled the applications of thermodynamically stable micelles in biomedicine, such as the encapsulation and solubilization of hydrophobic compounds for their site specific delivery. [16] Micellar catalysis in aqueous media has become a wellestablished green alternative to traditional catalysis in organic solvents. [17] The simple core-shell structure of micelles creates nanoenvironments or compartments separated from incompatible bulk media, reagents, or other catalysts.…”

Section: Introductionmentioning

confidence: 99%

Cross‐Linked Polymeric Micelles as Catalytic Nanoreactors

Kuepfert

Ahmed

et al. 2021

Eur J Inorg Chem

View full text Add to dashboard Cite

Cross-linked micelles have emerged as promising catalyst supports over the past two decades due to their improved structural stability, chemical diversity in multiple domains, and catalyst recovery compared to their uncross-linked analogues. We highlight the different physicochemical properties that arise by cross-linking the shell or core-domain and the subsequent impact on catalysis. Both, shell cross-linked micelles (SCMs) and core cross-linked micelles (CCMs) were initially designed to include one catalytic entity. Later on, SCMs were used to compartmentalize catalysts for non-orthogonal tandem catalysis while CCMs were investigated as phase transfer agents in biphasic catalysis. Current challenges in this field and new design trends for advanced micellar nanoreactors are discussed.

show abstract

“…Subsequently, Alkyne-PEG-MAL and Alkyne-PEG-OCH 3 were covalently attached by the azide–alkyne click chemistry to create the UiO-66-PEG-OCH 3 /MAL (UiO-66-PEG) conjugates. Click reactions have been widely used in biomedical applications due to their fast reaction speed and good reaction yield. − Such covalent modification is stable and controllable, and it can also provide functional sites for connecting tumor-targeting molecules.…”

Section: Introductionmentioning

confidence: 99%

PEGylated Nanoscale Metal–Organic Frameworks for Targeted Cancer Imaging and Drug Delivery

et al. 2021

View full text Add to dashboard Cite

Nanoscale metal−organic frameworks (nMOFs) are a unique type of hybrid materials, which are broadly applicable as cargo delivery systems. However, the relatively low material stability and insufficient cancer cell interacting capacity have limited nMOFs' applications in cancer theranostics. Herein, a zirconium-based nMOF UiO-66-N 3 was synthesized, and its surface was covalently functionalized with alkyne-containing polyethylene glycol (PEG) via the azide−alkyne click chemistry. After that, F3 peptide was attached for targeting of cancer cells (the material was denoted as UiO-66-PEG-F3). Doxorubicin (DOX) served as a therapeutic drug and a fluorescent label in this study, and it was transported into UiO-66-PEG conjugates with sufficient drug loading efficiency. pH-responsive release of DOX from UiO-66 conjugates was witnessed. The structural integrity of UiO-66-N 3 was maintained post the surface modification process. Flow cytometry and confocal fluorescence microscopy revealed that DOX/UiO-66-PEG-F3 had stronger accumulation in MDA-MB-231 cells (nucleolin + ) compared with DOX/UiO-66-PEG. In order to track the pharmacokinetic behavior (organ distribution profile) in vivo, the positron-emitting zirconium-89 ( 89 Zr) was incorporated into UiO-66-N 3 . Similar PEGylation and F3 peptide conjugation resulted in the formation of 89 Zr-UiO-66-PEG-F3. Serial positron emission tomography (PET) imaging demonstrated that the preferential accumulation of 89 Zr-UiO-66-PEG-F3 in MDA-MB-231 tumors, and their liver clearance was faster than PEGylated UiO-66 using noncovalent methods. Thus, the PEGylated nMOFs using covalent strategies may find broad application in future cancer theranostics.

show abstract

Recent Developments in the Area of Click‐Crosslinked Nanocarriers for Drug Delivery

Cited by 13 publications

References 113 publications

Click Chemistry Mediated by Photochemical Energy

Click Chemistry Mediated by Photochemical Energy

Cross‐Linked Polymeric Micelles as Catalytic Nanoreactors

PEGylated Nanoscale Metal–Organic Frameworks for Targeted Cancer Imaging and Drug Delivery

Contact Info

Product

Resources

About