“…Hemostatic, antiseptic and antiparasitic activities on wounds and skin infections are also reported for polysaccharides extracted from plants. These carbohydrates can also be used as tonic, stomach, abortifacient, antipyretic and for rheumatism [73] and some plants also have a piscicidal property. Polysaccharides can provide lubrication and thus facilitate the propulsion of colon contents by acting as a short-chain fatty acid production [13].…”
Section: Screening the Biological Potential Of Polysaccharides: Randomly Or Not?mentioning
confidence: 99%
“…As seen previously, the absence of polysaccharide toxicity (or very low) is an important aspect for their medical use [177]. Toxicity testing is an important step in the drug development process evaluating the potential of a medicinal plant before it can be considered for clinical trials [73]. Numerous patents have been filed on the use of natural polysaccharides as active drug ingredients [178].…”
Section: Economic Interestsmentioning
confidence: 99%
“…Such unique versatility allows these intelligent and durable hydrogels to be used in a wide range of applications, such as tissue engineering, biomedical devices, soft electronics, sensors, and actuators, among others; biomedical, controlled release and bioelectrode devices, minimally invasive deployment, gastric mucosal seals and perforations, electronic skin and electrochemical display devices, agricultural systems [1,179]. An increasing number of studies have focused on polysaccharide-based nanoparticle synthesis due to their unique structural properties [73]. One of the roles of these spherical biopolymers is to act as stabilizers as nano-carriers.…”
Polysaccharides are highly variable and complex biomolecules whose inventory of structures is still very incomplete, as nature still preserves unexplored biotopes. Plants, macroalgae and microalgae are an integral part of the daily life of human being regardless of culture, time, or knowledge development of a country. Natural medicine is an ancestral knowledge widely distributed throughout the world, handed down for centuries from generation to generation by those commonly referred to as “nganga” healers or shamans. It is also called alternative medicine or traditional medicine, and has been associated for millennia to legends. This review gives an emphasis regarding the ethnobotanic approach associated to the structural variability of poly- and oligosaccharides for designing the new polysaccharide-based drugs and hydrocolloids of tomorrow. The guiding thread is to survey the potential of plants (and some macroalgae) from Africa as a source of polysaccharides with original structures and, secondly, to correlate these structures with biological and/or functional properties in particular to address and advance the sustainable development and economic growth of mankind.
“…Hemostatic, antiseptic and antiparasitic activities on wounds and skin infections are also reported for polysaccharides extracted from plants. These carbohydrates can also be used as tonic, stomach, abortifacient, antipyretic and for rheumatism [73] and some plants also have a piscicidal property. Polysaccharides can provide lubrication and thus facilitate the propulsion of colon contents by acting as a short-chain fatty acid production [13].…”
Section: Screening the Biological Potential Of Polysaccharides: Randomly Or Not?mentioning
confidence: 99%
“…As seen previously, the absence of polysaccharide toxicity (or very low) is an important aspect for their medical use [177]. Toxicity testing is an important step in the drug development process evaluating the potential of a medicinal plant before it can be considered for clinical trials [73]. Numerous patents have been filed on the use of natural polysaccharides as active drug ingredients [178].…”
Section: Economic Interestsmentioning
confidence: 99%
“…Such unique versatility allows these intelligent and durable hydrogels to be used in a wide range of applications, such as tissue engineering, biomedical devices, soft electronics, sensors, and actuators, among others; biomedical, controlled release and bioelectrode devices, minimally invasive deployment, gastric mucosal seals and perforations, electronic skin and electrochemical display devices, agricultural systems [1,179]. An increasing number of studies have focused on polysaccharide-based nanoparticle synthesis due to their unique structural properties [73]. One of the roles of these spherical biopolymers is to act as stabilizers as nano-carriers.…”
Polysaccharides are highly variable and complex biomolecules whose inventory of structures is still very incomplete, as nature still preserves unexplored biotopes. Plants, macroalgae and microalgae are an integral part of the daily life of human being regardless of culture, time, or knowledge development of a country. Natural medicine is an ancestral knowledge widely distributed throughout the world, handed down for centuries from generation to generation by those commonly referred to as “nganga” healers or shamans. It is also called alternative medicine or traditional medicine, and has been associated for millennia to legends. This review gives an emphasis regarding the ethnobotanic approach associated to the structural variability of poly- and oligosaccharides for designing the new polysaccharide-based drugs and hydrocolloids of tomorrow. The guiding thread is to survey the potential of plants (and some macroalgae) from Africa as a source of polysaccharides with original structures and, secondly, to correlate these structures with biological and/or functional properties in particular to address and advance the sustainable development and economic growth of mankind.
“…It is native to North America, and copiously available throughout the world, especially in United States, Turkey, China, and France [1,2]. Corn silk is a thread-like silky material found between an ear of corn and an outer husk that expands from the female flower of the corn and changes color from light green to red/yellow/golden and brown [3]. Corn silk has been used in traditional medicine as an effective herbal remedy for alleviating symptoms of many diseases [1,3].…”
Section: Introductionmentioning
confidence: 99%
“…Corn silk is a thread-like silky material found between an ear of corn and an outer husk that expands from the female flower of the corn and changes color from light green to red/yellow/golden and brown [3]. Corn silk has been used in traditional medicine as an effective herbal remedy for alleviating symptoms of many diseases [1,3]. Some recent pharmacological studies [3,4] have shown the effectiveness of corn silk against hyperglycemia, obesity, cardiovascular and neurological disorders, cystitis, prostatitis, edema, nephritis, gout, urinary infections [5][6][7][8][9][10], inflammation [11], oxidative stress [12,13], and bacterial infections [14].…”
Phytochemical investigation of corn silk resulted in isolation and characterization of four flavone C-glycosides, chrysoeriol 6-C-β-oliopyranosyl-7-O-β-D-glucopyranoside (1), 3′-methoxycassiaoccidentalin A (2), chrysoeriol 6-C-β-boivinopyranosyl-7-O-β-D-glucopyranoside (3), and ax-4"-OH-3′-methoxymaysin (4), a triterpenoid, friedelin (5), two sterols, (22E)-5,8-epidioxyergosta-6,22-dien-3β-ol (6) and 6β-hydroxystigmasta-4,22-diene-3-one (7), and a mixture of β-sitosterol and stigmasterol. Compounds 1 and 2 were previously undescribed. Structure elucidation of the isolated compounds was attained using spectral data including 1D and 2D NMR and HRESIMS. Compounds 1, 2, 5, and 6 inhibited iNOS activity in LPS-induced macrophages and decreased nitrite levels by 68.64+4.46, 65.67 + 6.47, 88.50 + 0.50, and 94.00 + 4.00 %, respectively, at 50 µM. Compound 5 also showed inhibition of NF-κB (51.00+1.50 %). Compounds 1 and 2 induced NAG-1 activity in chondrocytes by 1.80 + 0.05 and 2.00 + 0.13 fold, respectively. The extract of corn silk, however, did not exhibit inhibition of iNOS or NF-κB but induced NAG-1 by 1.80+ 0.51 fold.
In this study, the second-order model, Fick’s second law of diffusion, and the Peleg model were used to evaluate the extraction kinetic model of polysaccharide (CPP) from
Codonopsis pilosula
. The characteristic functional groups, surface structure, and physical and chemical properties of CPP were analyzed by multi-spectroscopic and microscopic techniques. The results showed that the extraction process agreed well with the second-order model, Fick’s second diffusion law, and Peleg model. Rheological tests showed that CPP exhibited different viscosity changes under different conditions (Solution viscosity was inversely proportional to temperature, time, etc.; proportional to polysaccharide concentration, Na
+
content, etc.). CPP was composed of molecular aggregates composed of small particles, with more pore structure and basically completely decomposed at 130 °C. The hypoglycemic study showed that CPP had a strong inhibitory effect on α-glycosidase than α-amylase. The morphology and subsequent structural features, anti-diabetic potential, and rheological properties of CPP were revealed to provide a theoretical basis for the development of pharmaceutical preparations or health food and functional food for the treatment of diabetes.
Graphic Abstract
Supplementary Information
The online version contains supplementary material available at 10.1007/s13399-022-02518-w.
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