Recent developments in Process Systems Engineering as applied to medicine

Bogle, David

doi:10.1016/j.coche.2012.09.007

Current Opinion in Chemical Engineering

2012

DOI: 10.1016/j.coche.2012.09.007

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Recent developments in Process Systems Engineering as applied to medicine

David Bogle

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Cited by 5 publications

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“…Understanding how cells interact with and respond to the changes in their environment is essential for developing new approaches in biotechnology and medicine 9 10 . There is a continuous growing interest in applying Process Systems Engineering (PSE) techniques to biomedical problems 11 . For example, temperature is considered one of the fundamental factors in the analysis of cancer growth and a relationship between temperature and energy flow is evident when cellular metabolism is studied by analysing the substrate oxidative reactions 12 conditioned by the temperature itself 12 13 .…”

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Constructal thermodynamics combined with infrared experiments to evaluate temperature differences in cells

Lucia

Grazzini

Montrucchio

et al. 2015

Sci Rep

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The aim of this work was to evaluate differences in energy flows between normal and immortalized cells when these distinct biological systems are exposed to environmental stimulation. These differences were considered using a constructal thermodynamic approach, and were subsequently verified experimentally. The application of constructal law to cell analysis led to the conclusion that temperature differences between cells with distinct behaviour can be amplified by interaction between cells and external fields. Experimental validation of the principle was carried out on two cellular models exposed to electromagnetic fields. By infrared thermography we were able to assess small changes in heat dissipation measured as a variation in cell internal energy. The experimental data thus obtained are in agreement with the theoretical calculation, because they show a different thermal dispersion pattern when normal and immortalized cells are exposed to electromagnetic fields. By using two methods that support and validate each other, we have demonstrated that the cell/environment interaction can be exploited to enhance cell behavior differences, in particular heat dissipation. We propose infrared thermography as a technique effective in discriminating distinct patterns of thermal dispersion and therefore able to distinguish a normal phenotype from a transformed one.

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confidence: 99%

Constructal thermodynamics combined with infrared experiments to evaluate temperature differences in cells

Lucia

Grazzini

Montrucchio

et al. 2015

Sci Rep

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Liver function as an engineering system

et al. 2016

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Process Systems Engineering has tackled a wide range of problems including manufacturing, the environment, and advanced materials design. Here we discuss how tools can be deployed to tackle medical problems which involve complex chemical transformations and spatial phenomena looking in particular at the liver system, the body's chemical factory. We show how an existing model has been developed to model distributed behavior necessary to predict the behavior of drugs for treating liver disease. The model has been used to predict the effects of suppression of de novo lipogenesis, stimulation of b-oxidation and a combination of the two. A reduced model has also been used to explore the prediction of behavior of hormones in the blood stream controlling glucose levels to ensure that levels are kept within safe bounds using interval methods. The predictions are made resulting from uncertainty in two key parameters with oscillating input resulting from regular feeding. V C 2016 The Authors AIChE Journal published by Wiley Periodicals, Inc. on behalf of American Institute of Chemical Engineers AIChE J, 62: 3285-3297, 2016 Keywords: mathematical modeling, biomedical engineering, systems biology, medical, controlThe liver, its regulation, and its diseases Why systems engineering of the liver?Systems Engineering is the discipline of the management of complex engineering systems over their whole life cycle. Process Systems Engineering is the study of complex process engineering systems involving chemical and physical change. Prof Roger Sargent was a pioneer from the 1950s in seeing the potential that computers could have to revolutionize the way that we tackled these problems.1 He also saw the way Chemical Engineering was broadening its base into molecular and biological systems to improve manufacturing. 1,2The liver is one part of a very complex processing system which ensures that all parts of the body receive the energy and nutrients that they need, that waste products are removed efficiently from the various streams, and that short and long term well being are maintained. It is the body's central chemical processing organ. Considering the liver system as one which controls chemical and physical change within the body, particularly of nutrition, makes it a legitimate area of study for Process Systems Engineers. A number of Chemical Engineers have also contributed to the use for Process Systems Engineering to a range of medical applications. Bogle 3 reviews recent

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A process systems Engineering approach to analysis of fructose consumption in the liver system and consequences for Non-Alcoholic fatty liver disease

Liao

Davies

Bogle

2022

Chemical Engineering Science

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Recent developments in Process Systems Engineering as applied to medicine

Cited by 5 publications

References 18 publications

Constructal thermodynamics combined with infrared experiments to evaluate temperature differences in cells

Constructal thermodynamics combined with infrared experiments to evaluate temperature differences in cells

Liver function as an engineering system

A process systems Engineering approach to analysis of fructose consumption in the liver system and consequences for Non-Alcoholic fatty liver disease

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