Recent Developments in Metabolic Bone Diseases: a Gnathic Perspective

Raubenheimer, Erich J.; Noffke, C E E; Hendrik, Hilde D.

doi:10.1007/s12105-014-0580-2

Cited by 10 publications

(6 citation statements)

References 45 publications

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“… 39 – 44 Thus, osteopenia/osteoporosis is not considered an absolute contraindication for implant placement; 28 , 45 , 46 however, any concurrent medical histories including smoking, current, and recent radiotherapy, or the use of antiresorptive drugs present an additional risk of implant failure. 22 , 47 , 48 …”

Section: Introductionmentioning

confidence: 99%

Transcriptomic profiling of tantalum metal implant osseointegration in osteopenic patients

et al. 2018

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ObjectivesThe long-term success of dental implants is established by literature. Although clinically well defined, the complex genetic pathways underlying osseointegration have not yet been fully elucidated. Furthermore, patients with osteopenia/osteoporosis are considered to present as higher risk for implant failure. Porous tantalum trabecular metal (PTTM), an open-cell porous biomaterial, is suggested to present enhanced biocompatibility and osteoconductivity. The goal of this study was to evaluate the expression patterns of a panel of genes closely associated with osteogenesis and wound healing in osteopenic patients receiving either traditional titanium (Ti) or PTTM cylinders to assess the pathway of genes activation in the early phases of osseointegration.Material and methodsImplant cylinders made of Ti and PTTM were placed in osteopenic volunteers. At 2- and 4 weeks of healing, one Ti and one PTTM cylinder were removed from each subject for RT-PCR analysis using osteogenesis PCR array.ResultsCompared to Ti, PTTM-associated bone displayed upregulation of bone matrix proteins, BMP/TGF tisuperfamily, soluble ligand and integrin receptors, growth factors, and collagen genes at one or both time points. Histologically, PTTM implants displayed more robust osteogenesis deposition and maturity when compared to Ti implants from the same patient.ConclusionsOur results indicate that PTTM properties could induce an earlier activation of genes associated with osteogenesis in osteopenic patients suggesting that PTTM implants may attenuate the relative risk of placing dental implants in this population.

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Section: Introductionmentioning

confidence: 99%

Transcriptomic profiling of tantalum metal implant osseointegration in osteopenic patients

et al. 2018

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“…The early radiographic appearance of jawbone involvement in OFi are thinning of the cortices and loss of the lamina dura. 29 Root reabsorption and obliteration of the inferior alveolar canal are commonly found. 30 SBC can occur in association with FOCD, and SBC can manifest synchronously in jawbones.…”

Section: Teens and Those In Their 20smentioning

confidence: 99%

Synchronous jawbone diseases: a multicenter retrospective study

et al. 2023

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The aim of this study is to report an original case series of synchronous jawbone diseases. Data of patients seen over 13 years were extracted from the files of three Oral Radiology and Pathology diagnostic centers in Brazil. The clinical, radiographic, and laboratory characteristics were tabulated and analyzed by the authors; the patients were described according to lesion type. Seventy-two synchronous jawbone diseases were included in this study. Florid osseous dysplasia, Gorlin-Goltz syndrome, and cherubism were the most frequent disorders reported in this case series. In addition, the posterior mandible area was the main site of manifestation. Florid osseous dysplasia and Gorlin-Goltz syndrome represented two-thirds of our samples. With the utilization of adequate demographic, clinical, and radiologic information, it is possible to diagnose most of the synchronous lesions of jawbones. Sometimes, however, we need complementary exams, such as histopathologic and biochemical analysis or dosing of calcium, phosphorus, and alkaline phosphatase.

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“…Metabolic bone diseases (MBDs) include a significant spectrum of clinically related disorders, caused by calcium, phosphorus, magnesium or vitamin D abnormalities. The most common triggers for MBDs are hereditary hypophosphatemia, hyperparathyroidism or a deficiency of vitamin D. Osteoporosis, osteomalacia (with the childhood equivalent, rickets) and fluorosis are the most frequently diagnosed, while Paget’s disease, chronic kidney disease-mineral bone disorder, fibrous dysplasia and osteogenesis imperfecta are rarely met [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides-Calcium Phosphates Composite Beads as Bone Substitutes for Fractures Repair and Regeneration

et al. 2023

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The tendency of population aging is continuously increasing, which is directly correlated with a significative number of associated pathologies. Several metabolic bone diseases such as osteoporosis or chronic kidney disease–mineral and bone disorders involve a high risk of fractures. Due to the specific fragility, bones will not self-heal and supportive treatments are necessary. Implantable bone substitutes, a component of bone tissue engineering (BTE) strategy, proved to be an efficient solution for this issue. The aim of this study was to develop composites beads (CBs) with application in the complex field of BTE, by assembling the features of both biomaterials’ classes: biopolymers (more specific, polysaccharides: alginate and two different concentrations of guar gum/carboxymethyl guar gum) and ceramics (more specific, calcium phosphates), in a combination described for the first time in the literature. The CBs prepared by double crosslinking (ionic and physically) showed adequate physico-chemical characteristics and capabilities (morphology, chemical structure and composition, mechanical strength, and in vitro behaviour in four different acellular simulated body fluids) for bone tissue repair. Moreover, preliminary in vitro studies on cell cultures highlighted that the CBs were free of cytotoxicity and did not affect the morphology and density of cells. The results indicated that the beads based on a higher concentration of guar gum have superior properties than those with carboxymetilated guar, especially in terms of mechanical properties and behaviour in simulated body fluids.

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Recent Developments in Metabolic Bone Diseases: a Gnathic Perspective

Cited by 10 publications

References 45 publications

Transcriptomic profiling of tantalum metal implant osseointegration in osteopenic patients

Transcriptomic profiling of tantalum metal implant osseointegration in osteopenic patients

Synchronous jawbone diseases: a multicenter retrospective study

Polysaccharides-Calcium Phosphates Composite Beads as Bone Substitutes for Fractures Repair and Regeneration

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