Recent Developments in Isoxazole Chemistry

Synthesis and Characterization of Some New 1-(3-(heterocyclic-2-yl)-4,5-dihydroisoxazol-5-yl)Pentane-1,2,3,4,5-Pentaol Derivatives from New Chalcone

“…Isoxazoles possess interesting medicinal [2] properties and have some industrial utility [3]. Many biologically active isoxazoles and reduced isoxazole derivatives have been reported, viz., the naturally occurring antituberculosis, antibiotic cycloserine, the mono amine oxidase inhibitor: isocarboxazid, useful in psychotherapy and Isoxazole steroids show anabolic activity, eg., Denazole [4]. The CNS active isoxazoles, ibotenic acid, muscimol and muscazone are isolated from amanita muscaria and other amanita species.…”

Mild and efficient oxidation of 2-pyrazolines and isoxazolines by trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxalane–NH4Cl–HOAc in water–MeCN

“…Isoxazoles and 2-pyrazoles can be easily obtained by oxidation of isoxazolines [12][13][14][15][16][17] and 2-pyrazolines [18], respectively. Several methods have been reported for oxidation of isoxazolines and 2-pyrazolines including Pd-C-acetic acid [19], carbon-activated oxygen [20], cobalt soap of fatty acids [21] [23], manganese dioxide [24], potassium permanganate [24,25], silver nitrate [26], iodobenzene diacetate [27], zirconium nitrate [28], nickel peroxide [29], chromite [16], N-bromosuccinimide (NBS) [30], manganese triacetate [31], sodium bicarbonate-dimethylformamide [32], 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) [33], sodium carbonate-methanol [10], and tetrakis pyridine nickel(II) dichromate [34]. However, many of these methods have such disadvantages as long reaction times, low yields, and toxicity because of the elements present in the reagents used.…”

The Regiospecific Synthesis of Some New 3,5‐Disubstituted Isoxazoles

“…1 Various pharmacologically important isoxazoles with antibacterial, antiviral, antiinflammatory, antidiabetic, antifungal, antiparkinson, antihypertensive and antitumor activity have already been reported. 2 Isoxazoles are unique in their chemical behavior, not only among heterocyclic compounds in general, but also among related azoles. This is because isoxazoles possess the typical properties of the aromatic system, which are in fact rather pronounced in these derivatives, together with high lability of the ring under certain conditions, particularly at the nitrogen-oxygen bond.…”

“…This is because isoxazoles possess the typical properties of the aromatic system, which are in fact rather pronounced in these derivatives, together with high lability of the ring under certain conditions, particularly at the nitrogen-oxygen bond. 2 They were first synthesized in 1903. 3 The preparation of several isoxazoles with antipicornavirus activity has also been achieved by G. D. Diana et al 4,5 Recently, we synthesized new analogues of isoxazoles and studied their electrochemical behaviours.…”