Recent Developments in Instrumentation of Functional Near-Infrared Spectroscopy Systems

Althobaiti, Murad; Al-Naib, Ibraheem

doi:10.3390/app10186522

Cited by 26 publications

(18 citation statements)

References 98 publications

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“…To date, there are many medical applications of NIRS techniques [30], including monitoring of tissue oxygenation during muscle exercise, detecting tumors in the breast with a tomography technique [31], monitoring of the inflammatory process in rheumatoid arthritis disease, assessment of tissue perfusion, and peripheral microcirculation in healthy subjects [32,33] and scleroderma [34][35][36], monitoring of healing of venous leg ulcers [37], detection of brown adipose tissue activation [38], functional brain imaging for studies of neuro activation [39] in infants, small children or patients with epilepsy and brain mapping for neurosurgery (see Figure 2).…”

Section: Near-infrared Spectroscopy (Nirs)mentioning

confidence: 99%

“…All the commercially available NIRS instruments [40] require a source for the generation of light at a specific wavelength (generally a laser), a detector such as a photomultiplier tube (PMT) or a silicon photodiode, and finally, electronics for the two probes. Light can enter the tissue using continuous wave, frequency domain, or time-resolved mode [39]. The measurement can be obtained point-by-point or in imaging configuration: for a point measurement, only one source location and one or more detector locations are required, while to obtain an image each detector should be able to detect light from two or more source locations.…”

Section: Instrumentsmentioning

confidence: 99%

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The Core of Medical Imaging: State of the Art and Perspectives on the Detectors

et al. 2021

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In this review, the roles of detectors in various medical imaging techniques were described. Ultrasound, optical (near-infrared spectroscopy and optical coherence tomography) and thermal imaging, magnetic resonance imaging, computed tomography, single-photon emission tomography, positron emission tomography were the imaging modalities considered. For each methodology, the state of the art of detectors mainly used in the systems was described, emphasizing new technologies applied.

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Section: Near-infrared Spectroscopy (Nirs)mentioning

confidence: 99%

Section: Instrumentsmentioning

confidence: 99%

The Core of Medical Imaging: State of the Art and Perspectives on the Detectors

et al. 2021

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“…In the field of functional near-infrared spectroscopy (fNIRS) neuroimaging, a similar challenge faced the scientific community [29]- [31]. In this regard, the researchers are interested in measuring hemodynamic brain activities.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Dual-Channel Near-Infrared Non-Invasive Glucose Level Measurement Sensors Based On Monte-Carlo Simulations

Althobaiti

Al-Naib

2021

IEEE Photonics J.

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Non-invasive glucose monitoring sensors are promising techniques in diabetes management. In particular, optical-based nearinfrared glucose sensors are label-free, compact, user-friendly, and inexpensive. They require no daily calibration and can provide continuous glucose level monitoring. However, these sensors are still in the development stage since their accuracy is still not widely accepted by medical professionals. Here, we introduce an optimized dual-channel approach for this kind of sensor where four optodes for short and long channels are employed. The long channel signal that contains useful information about the glucose level can be utilized to calculate the glucose contents in the dermis layer of the skin while the short channel is utilized to measure the interference "noise" signal originating from the epidermis layer. So, the latter can then be removed from the long channel signal. This work investigates the optimal source-detector separation (SDS) of both short and long channels for a wide range of wavelengths from 1200 nm to 1900 nm. Based on the sensitivity distributions of both dermis and epidermis layers and the signal-to-noise ratio, it is suggested that a 2 mm SDS distance with a wavelength of 1450 nm is a potential choice for the short channel. Moreover, 6 mm SDS at the wavelength of 1750 nm is the optimal choice for the long channel. This work may pave the way for further optimization of non-invasive near-infrared glucose sensors that will be widely adopted in the healthcare sector.

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“…FDDOT works were completed by the researchers for different clinics with various imagers such as by placing source and detectors on the back-reflected, transmission, or ring geometry. The review of these works was compiled in the literature [6] .…”

Section: Introductionmentioning

confidence: 99%

Photon phase shift imaging research on frequency domain diffuse optic tomography

Kazancı

2021

Opt Quant Electron

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Diffuse optic imaging is an important biomedical optic research tool. Diffuse optic tomography (DOT) modality needs progressive philosophical approaches for scientific contribution. Technological developments and philosophical approaches should both go forward. Phase-shift based frequency domain (FD) diffuse optical tomography (FDDOT) method was well established in the literature. The instruments were tested for brain neurofunctional imaging. A mixture of AC laser intensity and phase data were used at these works. According to those works; deep volume resolution was improved by only using phase data.Because phase data is only related to the photon mean free path in imaging tissue media. Besides this advantage, laser intensity data is also affected by noisy background light and electrical artifacts. Another most important advantage of only using phase data can be explained as time-resolved temporal change can be directly related to phase shift of modulated frequency source. At this work, the frequency domain (FD) DOT imaging method which uses phase shift data were used for simulation phantom. Laser source-driven forward model problem weight matrix simulation data was given to the simple pseudo-inverse-based inverse problem solution algorithm for one inclusion example. The inclusion image was reconstructed and demonstrated successfully. Forward model problem weight functions inside the tissue simulation media were calculated and used based on the phase shifts at the same core modulation frequency. 100 MHz modulation frequency was selected due to its FDDOT standard. 13 sources and 13 detectors were placed on the back-reflected imaging surface. 40 x, y, z cartesian coordinate grid elements were used in the image reconstruction algorithm. Photon absorption coefficient: a = 0.1 cm -1 , and scattering coefficient: s = 100 cm -1 values were set for background simulation phantom. One inclusion object was embedded inside the imaging tissue simulation phantom background. x, y, z cartesian coordinate grid sizes were selected for 100 m for each direction. Photon phase shift fluencies were added to the forward model problem. The forward model problem was built according to the frequency domain photon migration diffusion approximation. Forward model problem photon fluencies were calculated according to the diffusion equation approximation. The simple pseudoinverse mathematical inverse problem solution algorithm was applied to test the results. The embedded inclusion object was reconstructed successfully with the high-resolution image quality. In general, DOT techniques suffer for the low image quality, but in this work, the high-quality image was reconstructed and demonstrated. The philosophical approach has future promising DOT imaging capability. The phase shift version of the FDDOT modality has an important advantage for future purpose.

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Recent Developments in Instrumentation of Functional Near-Infrared Spectroscopy Systems

Cited by 26 publications

References 98 publications

The Core of Medical Imaging: State of the Art and Perspectives on the Detectors

The Core of Medical Imaging: State of the Art and Perspectives on the Detectors

Optimization of Dual-Channel Near-Infrared Non-Invasive Glucose Level Measurement Sensors Based On Monte-Carlo Simulations

Photon phase shift imaging research on frequency domain diffuse optic tomography

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