Recent developments in innervation imaging using iodine-123-metaiodobenzylguanidine scintigraphy in Lewy body diseases

Treglia, Giorgio; Cason, Ernesto; Gabellini, A. S.; Giordano, Alessandro; Fagioli, Giorgio

doi:10.1007/s10072-010-0239-z

Cited by 21 publications

(51 citation statements)

References 34 publications

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“…Several MIBG studies have demonstrated that cardiac sympathetic denervation occurs in patients with LBD. [2][3][4][6][7][8] Treglia et al Recent evidence supports the notion that myocardial sympathetic involvement is a very early event in the evolution of LBD in humans, occurring prior to the deposition of α-synuclein pathology in the central nervous system in many patients. 9,10 Several investigators have, therefore, suggested that myocardial MIBG scintigraphy could be used to identify those with underlying LBD regardless of the other clinical features being exhibited; therefore, reduced myocardial MIBG uptake may be one of the most specific biomarkers for underlying LBD.…”

Section: Introductionmentioning

confidence: 82%

“…Labeling MIBG with iodine-123 permits the visualization of adrenergic innervation in vivo; MIBG scintigraphy not only displays the presence of noradrenergic innervation, but also its functional capability. [1][2][3][4] About myocardial innervation imaging, radiolabeled MIBG is intravenously administered at rest, and early (from 10 to 30 min after injection) and delayed (from 3 to 4 h after injection) images are obtained (see Figures 1 and 2). Planar images with anterior view are adequate for the evaluation of cardiac sympathetic function.…”

Section: Scintigraphic Methodsmentioning

confidence: 99%

“…Tomographic images (single photon emission computed tomography) are often acquired to evaluate the three-dimensional myocardial uptake pattern. [1][2][3][4] The most common semiquantitative indices used for interpretation of myocardial innervation images are the heart to mediastinum (H/M) ratio and the washout rate (WR) obtained from the anterior planar images. Regions of interest (ROIs) are set in the heart (H; target region) and the mediastinum (M; background region) in early and delayed images to obtain the mean count in each ROI, after which the H/M ratio is calculated.…”

Section: Scintigraphic Methodsmentioning

confidence: 99%

“…[1][2][3][4] In recent years, it has been revealed that Parkinson's disease (PD) and dementia with Lewy bodies (DLB) share one clinicopathological entity: Lewy body disease (LBD) has thus become a general term for these diseases. 5 LBD presents an impairment of adrenergic function and consequently an abnormal myocardial MIBG innervation imaging: the involvement of myocardial postganglionic sympathetic nerves may account for the reduction of myocardial MIBG uptake in patients with DLB, as well as in patients with PD.…”

Section: Introductionmentioning

confidence: 99%

“…5 LBD presents an impairment of adrenergic function and consequently an abnormal myocardial MIBG innervation imaging: the involvement of myocardial postganglionic sympathetic nerves may account for the reduction of myocardial MIBG uptake in patients with DLB, as well as in patients with PD. [2][3][4][5] Like PD and DLB, other Lewy body disorders, including pure autonomic failure and idiopathic rapid eye movement (REM) sleep behavior disorder (RBD), have been reported to develop cardiac sympathetic denervation. Several MIBG studies have demonstrated that cardiac sympathetic denervation occurs in patients with LBD.…”

Section: Introductionmentioning

confidence: 99%

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Usefulness of MIBG scintigraphy in idiopathic REM sleep behavior disorder: a systematic review

Treglia¹,

Cocciolillo²,

Stefanelli³

et al. 2011

RRNM

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Background and purpose:It has been widely demonstrated that Parkinson's disease (PD) and dementia with Lewy bodies (DLB) share one clinicopathological entity; Lewy body disease (LBD) has thus become a general term for these diseases. LBD presents an impairment of adrenergic function and consequently an abnormal myocardial metaiodobenzylguanidine (MIBG) innervation imaging. Like PD and DLB, other Lewy body disorders, including pure autonomic failure and idiopathic rapid eye movement sleep behavior disorder (RBD), have been reported to develop cardiac sympathetic denervation. This study is designed to systematically review whether iodine-123-MIBG scintigraphy in patients with RBD demonstrates reduced myocardial uptake thereby suggesting cardiac sympathetic denervation, a typical finding of LBD, in these patients. Methods: A comprehensive computer literature search of studies published through December 2010 regarding MIBG scintigraphy in patients with RBD was performed in PubMed/Medline and EMBASE databases. Only studies in which MIBG scintigraphy was performed in more than two patients with RBD were selected. Results: Ultimately, six studies comprising a total of 139 patients with RBD were identified and discussed. Conclusions: RBD usually show a markedly reduced cardiac MIBG uptake, consistent with a sympathetic denervation, a typical finding of a LBD.

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Section: Introductionmentioning

confidence: 82%

Section: Scintigraphic Methodsmentioning

confidence: 99%

Section: Scintigraphic Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Usefulness of MIBG scintigraphy in idiopathic REM sleep behavior disorder: a systematic review

Treglia¹,

Cocciolillo²,

Stefanelli³

et al. 2011

RRNM

Self Cite

View full text Add to dashboard Cite

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Movement disorders: role of imaging in diagnosis

Mascalchi

Vella

Ceravolo

2012

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI and single‐photon emission computed tomography (SPECT) have a considerable role in the diagnosis of the single patient with movement disorders. Conventional MRI demonstrates symptomatic causes of parkinsonism but does not show any specific finding in Parkinson's disease (PD). However, SPECT using tracers of the dopamine transporter (DAT) demonstrates an asymmetric decrease of the uptake in the putamen and caudate from the earliest clinical stages. In other degenerative forms of parkinsonism, including progressive supranuclear palsy (PSP), multisystem atrophy (MSA), and corticobasal degeneration (CBD), MRI reveals characteristic patterns of regional atrophy combined with signal changes or microstructural changes in the basal ganglia, pons, middle and superior cerebellar peduncles, and cerebral subcortical white matter. SPECT demonstrates a decreased uptake of tracers of the dopamine D2 receptors in the striata of patients with PSP and MSA, which is not observed in early PD. MRI also significantly contributes to the diagnosis of some inherited hyperkinetic conditions including neurodegeneration with brain iron accumulation and fragile‐X tremor/ataxia syndrome by revealing characteristic symmetric signal changes in the basal ganglia and middle cerebellar peduncles, respectively. A combination of the clinical features with MRI and SPECT is recommended for optimization of the diagnostic algorithm in movement disorders. J. Magn. Reson. Imaging 2012;239‐256. © 2011 Wiley Periodicals, Inc.

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