Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology

Dent, Elsa; Hanlon, Peter; Sim, Marc; Jylhävä, Juulia; Liu, Zuyun; Vetrano, Davide L.; Stolz, Erwin; Pérez-Zepeda, Mario Ulises; Crabtree, Daniel R.; Nicholson, Caroline; Job, Jenny; Ambagtsheer, Rachel C.; Ward, Paul R.; Shi, Sandra M.; Huynh, Quan; Hoogendijk, Emiel O.

doi:10.1016/j.arr.2023.102082

Cited by 10 publications

(2 citation statements)

References 191 publications

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“…Frail patients demonstrate decreased physiologic reserve and impaired responses to physiologic stresses, including illness and surgery [53,54]. Poor functional status is a known predictor of postoperative mortality and postoperative length of stay, and frail patients show significantly increased risk of complications even following ambulatory and minor surgical procedures [55].…”

Section: Frailty and Decreased Functional Statusmentioning

confidence: 99%

Lingering effects of COVID-19 in the care of perioperative patients

Jia,

Navare,

Hoyler

2024

Current Opinion in Anaesthesiology

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Purpose of review Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can lead to organ dysfunction and clinical symptoms beyond the acute infection phase. These effects may have significant implications for the management of perioperative patients. The purpose of this article is to provide a systems-based approach to the subacute and chronic effects of SARS-CoV-2 that are most relevant to anesthesiology practice. Recent findings In 2024, COVID-19 remains a concern for anesthesiologists due ongoing new infections, evolving viral strains, and relatively low rates of booster vaccination in the general population. A growing body of literature describes the post-COVID-19 syndrome in which patients experience symptoms more than 12 weeks after acute infection. Recent literature describes the lingering effects of SARS-CoV-2 infection on all major organ systems, including neurologic, pulmonary, cardiovascular, renal, hematologic, and musculoskeletal, and suggests an increased perioperative mortality risk in some populations. Summary This review offers anesthesiologists an organ system-based approach to patients with a history of COVID-19. Recognizing the long-term sequelae of SARS-CoV-2 infection can help anesthesiologists to better evaluate perioperative risk, anticipate clinical challenges, and thereby optimize patient care.

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Section: Frailty and Decreased Functional Statusmentioning

confidence: 99%

Lingering effects of COVID-19 in the care of perioperative patients

Jia,

Navare,

Hoyler

2024

Current Opinion in Anaesthesiology

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“…It is postulated that bacteria present in the oral cavity may serve as potential pathogens implicated in the etiology of respiratory infections (Gomes‐Filho et al, 2010; Scannapieco, 1999). A narrative review has revealed that there is an emerging need for early identification and management of oral frailty in older adults to prevent frailty (Dent et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

The relationship between oral frailty and oral dysbiosis among hospitalized patients aged older than 50 years

Chen,

Ku,

Tsai

et al. 2024

Clinical & Exp Dental Res

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ObjectiveThis study aimed to clarify the relationship between oral frailty and oral dysbiosis among hospitalized patients aged ≥ 50 years.MethodsA prospective observational study was conducted. Number of teeth, masticatory ability, articulatory oral motor skill, tongue pressure, swallowing pressure, and choking were used to assess oral frailty. Saliva samples were collected from the oral cavity for bacterial culture.ResultsA total 103 in patients enrolled and 53.4% suffered from oral frailty. Oral frailty was found to have a 3.07‐fold correlation with the presence of Enterobacterales in the oral cavity (p = 0.037), especially in poor articulatory oral motor skill, which showed at greater risk of Enterobacterales isolated from the oral cavity by 5.58‐fold (p = 0.01).ConclusionHalf of hospitalized patients was found to have oral frailty that was related to more Enterobacterales in the oral cavity. This evidence suggests that the enhancement of articulatory oral motor skills may serve as a potential strategy for mitigating the presence of Enterobacterales within the oral cavity.

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Higher plant-derived nitrate intake is associated with lower odds of frailty in a cross-sectional study of community-dwelling older women

Hayes,

Dent,

Shannon

et al. 2024

Eur J Nutr

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Purpose Dietary nitrate intake is inversely related to numerous contributors towards frailty, including cardiovascular disease and poor physical function. Whether these findings extend to frailty remain unknown. We investigated if habitual nitrate intake, derived from plants or animal-based foods, was cross-sectionally associated with frailty in women. Methods Community-dwelling older Australian women (n = 1390, mean age 75.1 ± 2.7 years) completed a validated semi-quantitative food frequency questionnaire (FFQ). Nitrate concentrations in food were obtained from international nitrate databases. We adopted the Rockwood frailty index (FI) of cumulative deficits comprising 33 variables across multiple health domains (scored 0 to 1), which predicts increased hospitalisation and mortality risk. A FI ≥ 0.25 indicated frailty. Cross-sectional associations between nitrate intake (total plant and animal nitrate, separately) and frailty were analysed using multivariable-adjusted logistic regression models (including lifestyle factors), as part of restricted cubic splines. Results A non-linear inverse relationship was observed between total plant nitrate intake and frailty. Compared to women with the lowest plant nitrate intake (Quartile [Q]1), women with greater intakes in Q2 (OR 0.69 95%CI 0.56–0.84), Q3 (OR 0.67 95%CI 0.50–0.90) and Q4 (OR 0.66 95%CI 0.45–0.98) had lower odds for frailty. A nadir in the inverse association was observed once intakes reached ~ 64 mg/d (median Q2). No relationship was observed between total animal nitrate and frailty. Conclusion Community-dwelling older women consuming low amounts of plant-derived nitrate were more likely to present with frailty. Consuming at least one daily serving (~ 75 g) of nitrate-rich green leafy vegetables may be beneficial in preventing frailty.

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Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology

Cited by 10 publications

References 191 publications

Lingering effects of COVID-19 in the care of perioperative patients

Lingering effects of COVID-19 in the care of perioperative patients

The relationship between oral frailty and oral dysbiosis among hospitalized patients aged older than 50 years

Higher plant-derived nitrate intake is associated with lower odds of frailty in a cross-sectional study of community-dwelling older women

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