Recent Developments in Enantioselective Domino Reactions. Part B: First Row Metal Catalysts

Abstract

This review updates the field of enantioselective domino reactions promoted by chiral catalysts derived from first row metals, such as zinc, iron, copper, scandium, nickel, cobalt, titanium, chromium and magnesium as special case, published since the beginning of 2019. It illustrates how much a diversity of these catalysts allow an impressive range of novel highly enantioselective domino reactions of many types to be achieved, providing a one‐pot access to very complex and functionalized chiral molecules from simple starting materials.

Recent Developments in Enantioselective Scandium-Catalyzed Transformations

“…A wide number of asymmetric domino reactions have been successfully catalyzed by many types of chiral metal complexes, allowing the synthesis of very complex molecules [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. In the last few years, different types of chiral ligands, including N,N ′ -dioxides, pyridine-2,6-bisoxazolines, bipyridines, phosphine oxides, and phosphoric acids, have been chelated to scandium to promote a range of unprecedented highly efficient domino reactions.…”

Recent Advances in the Domino Annulation Reaction of Quinone Imines

“…By exploring a series of reliable synthetic methods, it is possible to efficiently construct the structurally complex molecular frameworks found in natural products and biologically active compounds, including carbocyclic and heterocyclic structures, thereby facilitating the discovery of potential new drugs and pesticides [ 7 , 8 , 9 , 10 , 11 , 12 ]. Among the numerous reported synthetic strategies, domino reactions have attracted considerable attention due to their potential to conserve resources, reduce waste generation during the synthesis process, and align with the principles of green chemistry [ 13 , 14 , 15 , 16 ]. Most importantly, they enable the rapid assembly of polycyclic structures from simple starting materials [ 17 , 18 , 19 , 20 , 21 , 22 ].…”

Asymmetric cascades of the π-allyl complex: a journey from transition-metal catalysis to metallaphotocatalysis

“…Catalytic enantioselective cascades have been one of the preferred strategies for the construction of asymmetric C–C and C–X centres. 1–12 These processes are so economical and viable that they have found abundant use among the synthetic community and have been used for the synthesis of valuable bio-active natural products, pharmacophores, and synthetically useful intermediates. In this domain, the enantioselectivity could be achieved through organocatalysis or transition-metal catalysis, where a transition metal complex is used along with a chiral ligand.…”