Recent developments in detection and therapeutic approaches for antibiotic-resistant bacterial infections

Abstract

Owing to the widespread emergence and proliferation of antibiotic-resistant bacteria, the therapeutic benefits of antibiotics have been reduced. In addition, the ongoing evolution of multidrug-resistant pathogens poses a challenge for the scientific community to develop sensitive analytical methods and innovative antimicrobial agents for the detection and treatment of drug-resistant bacterial infections. In this review, we have described the antibiotic resistance mechanisms that occur in bacteria and summarized the recent developments in detection strategies for monitoring drug resistance using different diagnostic methods in three aspects, including electrostatic attraction, chemical reaction, and probe-free analysis. Additionally, to understand the effective inhibition of drug-resistant bacterial growth by recent nano-antibiotics, the underlying antimicrobial mechanisms and efficacy of biogenic silver nanoparticles and antimicrobial peptides, which have shown promise, and the rationale, design, and potential improvements to these methods are also highlighted in this review. Finally, the primary challenges and future trends in the rational design of facile sensing platforms and novel antibacterial agents against superbugs are discussed.

Evaluating Antioxidant Performance, Biosafety, and Antimicrobial Efficacy of Houttuynia cordata Extract and Microwave-Assisted Synthesis of Biogenic Silver Nano-Antibiotics

“…Moreover, the influence of silver nanomaterials on bacterial cells and the production of ROS in bacterial cells were also examined. The experimental finding revealed that HCE-AgNPs induce oxidative stress by damaging the cell wall, ultimately resulting in cell death [24,51]. Additionally, ATP, which is involved in the metabolism of cellular energy, was reduced due to the remarkable inhibition by the AgNPs, causing bacterial apoptosis.…”

A bismuth-based double-network hydrogel-mediated synergistic photothermal-chemodynamic therapy for accelerated wound healing

“…2,3 However, the misuse of antibiotics has contributed to the emergence of multidrug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA), severely hindering the effectiveness of treatments. 4–6…”

Synthesis of Benzylpenicillin esters and evaluate the change in the anti-bacterial effects by Docking and bacteriological study

“…Most developed drug candidates fail the clinical stages due to their substandard pharmacokinetic properties, and the introduction of a new treatment to the market normally takes 10 to 15 years and a substantial expenditure. Therefore, it is imperative to construct fresh, cutting-edge methods for creating new medications, especially antibiotics [15]. Antimicrobial actions and selectivity with target sites have been enhanced through the use of technology like computational methods like in silico and Fragment-based drug design FBDD [16].…”