Recent developments in comprehensive two-dimensional gas chromatography (GC×GC)

Adahchour, M.; Beens, Jan; Vreuls, René J. J.; Brinkman, U.A.Th.

doi:10.1016/j.trac.2006.03.002

Cited by 270 publications

(139 citation statements)

References 255 publications

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“…Observing the experimental conditions described, just two analytes (exemestane and furazabol metabolite) presented wrap-around, the phenomenon in which second-dimension peaks leave the second column in a modulation later than the one in which they entered the second column. 39 The classic wrap around profile for exemestane can be observed in Figure 1. Despite the wrap-around, a correct identification of analytes occurred in both cases without harming qualitative analysis.…”

Section: Resultsmentioning

confidence: 96%

Specificity and selectivity improvement in doping analysis using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry

Barbosa¹,

Leal²,

Padilha³

et al. 2012

Quím. Nova

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Recebido em 5/9/11; aceito em 21/11/11; publicado na web em 31/1/12Comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry was used for the identification of forty doping agents. The improvement in the specificity was remarkable, allowing the resolution of analytes that could not be done by one-dimensional chromatographic systems. The sensitivity observed for different classes of prohibited substances was clearly below the value required by the World Anti-Doping Agency. In addition time-of-flight mass spectrometry gives full spectrum for all analytes without any interference from the matrix, resulting in selectivity improvements. These results could support the implementation of an exhaustive monitoring approach for hundreds of doping agents in a single injection.

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Section: Resultsmentioning

confidence: 96%

Specificity and selectivity improvement in doping analysis using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry

Barbosa¹,

Leal²,

Padilha³

et al. 2012

Quím. Nova

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“…Fig. 7.34 shows one of the often-cited figures (Adahchour et al, 2006) that clearly illustrates how data from 2D-LC experiments are handled to produce 2D chromatograms. In the absence of software dedicated to the analysis of 2D-LC data, these steps can be accomplished by first exporting raw data from the chromatography data system, and then manipulating those data using any of a number of programming and analysis packages such as MatLab or Mathematica.…”

Section: Data Analysis Software and Quantitationmentioning

confidence: 99%

Theory and Practice of UHPLC and UHPLC–MS

Guillarme

Veuthey

2017

Handbook of Advanced Chromatography /Mass Spectrometry Techniques

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“…Most popular are the cryogenic modulators where fractions from the first column are trapped and released onto the second-dimension column by repeated cooling and heating of cryotraps. For a more detailed discussion on modulators for GC6GC, the reader is referred to the recent literature [25]. In LC6LC and LC6GC, interfaces can be constructed from standard LC valves.…”

Section: Principles Of Comprehensive Multidimensional Separationsmentioning

confidence: 99%

The role of comprehensive chromatography in the characterization of edible oils and fats

Janssen

Steenbergen

Koning³

2009

Euro J Lipid Sci & Tech

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Chromatography has a very long history in the analysis of edible oils and fats. Hyphenations of two chromatographic methods, or couplings of a chromatographic separation technique with spectroscopic detection and identification devices, are used if the resolving power of the technique needs to be improved. More recently, the analytical benefits of comprehensive two-dimensional (2D) chromatography, in its various operational modes, have been exploited by the oil and fat chromatographic community. In comprehensive 2D chromatography, the entire sample injected is subjected to two independent separation processes. In the present contribution, the principles of comprehensive 2D chromatography are briefly discussed. Next, the advantages of comprehensive separations for lipid analysis are illustrated using the concept of generic chromatographic applications. This concept distinguishes three generic reasons to apply chromatographic separations: target compound analysis, group-type separation, and chromatographic fingerprinting. Examples of how comprehensive multi-dimensional methods were successfully applied to solve problems in the edible oils and fats area are given. We believe that these multi-dimensional techniques truly add new dimensions to oil and fat analysis, providing researchers in the area with novel tools for unraveling edible oil or fat samples with their complex compositions.

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Recent developments in comprehensive two-dimensional gas chromatography (GC×GC)

Cited by 270 publications

References 255 publications

Specificity and selectivity improvement in doping analysis using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry

Specificity and selectivity improvement in doping analysis using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry

Theory and Practice of UHPLC and UHPLC–MS

The role of comprehensive chromatography in the characterization of edible oils and fats

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