Recent developments in biomedical applications of metasurface optics

We proposed a sensor architecture for surface-enhanced Raman scattering (SERS) based on Fe ion doped LN (FLN) crystal, which was modified by large-area laser-induced periodic surface structures (LIPSS) and subsequently decorated with Ag nanoparticles (Ag NPs). Based on such a FLN/LIPSS/Ag substrate, strikingly boosted SERS enhancement was obtained at constant temperature owing to the LIPSS-related hot spot improvement. Benefiting from the pyroelectric effect of the FLN crystal, further enhanced SERS was achieved under heating and cooling processes, which can be ascribed to the additional charge transfer between molecules and Ag NPs triggered by pyroelectric potential. The experimental results highlight the high fabrication efficiency, ultrasensitivity, high uniformity, and high universality of the substrate, integrating the advantages of both LIPSS and the FLN crystal. More interestingly, selective suppression of Raman signals under cooling processes was observed, which further extends the applications of the FLN/LIPSS/Ag substrate for the detection of molecule complexes such as lake water polluted by crystal violet and 4-aminothiophenol molecules.

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Design and development of a portable compound microscope for interactive bioscience learning

Waheed,

Javed,

Zubair

2024

Optical Instrument Science, Technology, and Applications III

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Many biological processes and microstructures are imperceptible to the naked eye. To pose this challenge microscope is regarded as an indispensable tool for studying and working with the microworld. With the use of a microscope, one can examine an object at the cellular level and determine the structure of cells, tissues, and microbes. Using microscopes, science, technology, engineering, and math (STEM), education has been able to overcome significant obstacles, and learning has become more interactive and engaging. Students can explore the intricate details of the microstructures they are studying, which enhances comprehension and retention of knowledge. In biology courses, students are encouraged to engage in hands-on microscope experiments. With the remarkable technological advancements in interactive learning (IL) over the last decade, there has been a notable increase in productivity and interactivity. Consequently, IL has emerged as a potentially valuable way to enhance the understanding and practical competencies of students. This study introduces an educational compound microscopic system that utilizes IL technology to facilitate the examination of under-observation samples by showing information in real time. Students can complete most microscope-based experiments in biology courses and will be able to identify and analyze the biological samples when the prepared slides are seen under our designed compound microscope. The integration of IL technology enhances the performance and applicability of traditional compound microscopes. In addition to this, our portable microscope is costeffective, easy to use, and more efficient than traditional compound microscopes utilized for education purposes.

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Recent developments in biomedical applications of metasurface optics

Cited by 3 publications

References 126 publications

A metasurface processor that supports synchronous operation of analog and digital computing

A metasurface processor that supports synchronous operation of analog and digital computing

Laser-induced periodic surface structures on Fe ion doped LN crystal for pyroelectric SERS analysis

Design and development of a portable compound microscope for interactive bioscience learning

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