Recent Developments for the Facile Synthesis of Triazole‐Fused Heterocyles

A Facile One-Pot Synthesis of New Poly Functionalized Pyrrolotriazoles via a Regioselective Multicomponent Cyclisation and Suzuki–Miyaura Coupling Reactions

“…1 H NMR (400 MHz, Chloroform-d): δ 7.38-7.17 (m, 9H), 6.91 (s, 1H), 5.26 (s, 2H), 4.87 (hept, J = 6.8 Hz, 1H), 2.37 (s, 3H), 1.60 (d, J = 6.8 Hz, 6H). 13 C NMR (101 MHz, Chloroform-d): δ 151.1 (C q ), 136.9 (C q ), 136.3 (C q ), 130.8 (C q ), 129.5 (2 × CH Ar ), 128.8 (2 × CH Ar ), 128.0 (CH Ar ), 128.0 (2 × CH Ar ), 127.7 (2 × CH Ar ), 127.2 (CH Ar ), 125.3 (C q ), 106.9 (C q ), 52.7 (CH), 50.6 (CH 2 ), 22 The reaction was carried out as described in general procedure C using 6-bromo-1-(4-Methoxybenzyl)-4-methyl-1,4-dihydropyrrolo [2,3-d][1,2,3]triazole 21 (58 mg, 0.18 mmol, 1.0 eq. ), p-tolyl boronic acid (37 mg, 0.27 mmol, 1.5 eq.…”

“…For these reasons, their introduction in medicinal chemistry programs has grown, in particular in the context of molecular diversity and innovative chemical space research [18,19]. These two small heterocycles have been fused in bicyclic systems [20][21][22][23][24], providing original building blocks for medicinal chemists [25,26]. Nevertheless, the literature reports only one example of these two cycles combined together in a [5:5] fused ring which was designed by Cirrincione et al to access benzylated pyrrolo [2,3-d] [1,2,3]triazoles of type B [27].…”