Recent Developments and Chemical Diversity of Cone Snails with Special Reference to Indian Cone Snails

Palanisamy, Satheesh Kumar; Dhanabalan, Senthil Kumar; Sundaresan, Umamaheswari

doi:10.1002/9783527801718.ch14

Cited by 1 publication

(1 citation statement)

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“…As all conotoxins reported, our conotoxin could be modulating a receptor or channel, in this case on bacterial membrane. As we know, the O1 superfamily is one of the largest groups composed of six cysteine frameworks (VI/VII, XII, I, XIV, IX, XVI), with extensive target repertoire over ion channel [ 20 ]. In this report, we included to O1_cal29b in a new framework not described before in this superfamily.…”

Section: Discussionmentioning

confidence: 99%

The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity

Bernáldez-Sarabia

Figueroa-Montiel

Dueñas

et al. 2019

Toxins

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Californiconus californicus, previously named Conus californicus, has always been considered a unique species within cone snails, because of its molecular, toxicological and morphological singularities; including the wide range of its diet, since it is capable of preying indifferently on fish, snails, octopus, shrimps, and worms. We report here a new cysteine pattern conotoxin assigned to the O1-superfamily capable of inhibiting the growth of Mycobacterium tuberculosis (Mtb). The conotoxin was tested on a pathogen reference strain (H37Rv) and multidrug-resistant strains, having an inhibition effect on growth with a minimal inhibitory concentration (MIC) range of 3.52–0.22 μM, similar concentrations to drugs used in clinics. The peptide was purified from the venom using reverse phase high-performance liquid chromatography (RP-HPLC), a partial sequence was constructed by Edman degradation, completed by RACE and confirmed with venom gland transcriptome. The 32-mer peptide containing eight cysteine residues was named O1_cal29b, according to the current nomenclature for this type of molecule. Moreover, transcriptomic analysis of O-superfamily toxins present in the venom gland of the snail allowed us to assign several signal peptides to O2 and O3 superfamilies not described before in C. californicus, with new conotoxins frameworks.

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Section: Discussionmentioning

confidence: 99%