Recent Development of Photothermal Agents (PTAs) Based on Small Organic Molecular Dyes

Lv, Shibo; Miao, Yuyang; Liu, Dapeng; Song, Fengling

doi:10.1002/cbic.202000089

Cited by 61 publications

(29 citation statements)

References 118 publications

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“…), and some organic small molecule photothermal agents (porphyrin, phthalocyanine, cyanine, etc.) (Lv et al, 2020). The current research aims to develop materials with excellent biocompatibility in addition to photothermal performance.…”

Section: Nanomaterials Used In Photothermal Therapy and Photodynamic ...mentioning

confidence: 99%

Recent Advance of Nanomaterial-Mediated Tumor Therapies in the Past Five Years

Hao

Xiang

et al. 2022

Front. Pharmacol.

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Cancer has posed a major threat to human life and health with a rapidly increasing number of patients. The complexity and refractory of tumors have brought great challenges to tumor treatment. In recent years, nanomaterials and nanotechnology have attracted more attention and greatly improved the efficiency of tumor therapies and significantly prolonged the survival period, whether for traditional tumor treatment methods such as radiotherapy, or emerging methods, such as phototherapy and immunotherapy, sonodynamic therapy, chemodynamic therapy and RNA interference therapeutics. Various monotherapies have obtained positive results, while combination therapies are further proposed to prevent incomplete eradication and recurrence of tumors, strengthen tumor killing efficacy with minimal side effects. In view of the complementary promotion effects between different therapies, it is vital to utilize nanomaterials as the link between monotherapies to achieve synergistic performance. Further development of nanomaterials with efficient tumor-killing effect and better biosafety is more in line with the needs of clinical treatment. In a word, the development of nanomaterials provides a promising way for tumor treatment, and here we will review the emerging nanomaterials towards radiotherapy, phototherapy and immunotherapy, and summarized the developed nanocarriers applied for the tumor combination therapies in the past 5 years, besides, the advances of some other novel therapies such as sonodynamic therapy, chemodynamic therapy, and RNA interference therapeutics have also been mentioned.

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Section: Nanomaterials Used In Photothermal Therapy and Photodynamic ...mentioning

confidence: 99%

Recent Advance of Nanomaterial-Mediated Tumor Therapies in the Past Five Years

Hao

Xiang

et al. 2022

Front. Pharmacol.

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“…The ACQ of luminescence may enhance the photothermal conversion efficiency of NIR dyes, which provides a straightforward strategy for the design of more efficient photothermal nanoagents without structural modulation. [58,59] For instance, Liu and co-workers utilized the surfactant-stripped frozen micelles method by using F127 to noncovalently confer a hydrophobic NIR dye, β-thiophene-fused BF 2 -azadipyrromethene (aza-BDTP) with excellent aqueous solubility. The resulting aza-BDTP-containing micelles exhibited high photothermal conversion efficiency at 33.9%, significantly higher than 16.9% for bare aza-BDTP molecules, owing to ACQ of aza-BDTP fluorescence.…”

Section: Aggregation Of Nir Dyementioning

confidence: 99%

Luminescent nano‐bioprobes based on NIR dye/lanthanide nanoparticle composites

et al. 2021

Aggregate

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Near-infrared (NIR) light, which has ignorable tissue scattering/absorption, minimal photodamage, and no autofluorescence interference, is highly favorable for bioapplications. NIR dye and lanthanide-doped nanoparticle (LnNP), as representative NIR-excited luminescence probes, have attracted increasing interest due to their unique optical property and low biological toxicity. Design of luminescence probes based on NIR dye/LnNP nanocomposites cannot only integrate the advantages but also achieve additional functions via regulating internal energy transfer pathways. In this review, we focus on the most recent advances in the development of NIR dye/LnNP nanocomposites as potential bioprobes, which cover from their fundamental photophysics to bioapplications, including energy transfer mechanisms, interface engineering (involving binding interaction, distance, and aggregation as key factors), and their applications for dye-sensitized upconversion/downshifting luminescent bioimaging, detection of biomolecules, and NIR-triggered diagnosis and therapy. Some future prospects and efforts toward this active research field are also envisioned. K E Y W O R D S dye sensitization, energy transfer, interface engineering, lanthanide-doped nanoparticle, nano-bioprobe, NIR dye This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…PTT relies on photothermal agents (PTAs) that can convert the absorbed light energy into heat, which causes the local temperature of the tumor issues increasing, and finally plays the role of cancer cell apoptosis inducer. Based on related literatures, the synthesized PTAs can be categorized into three types: organic small-molecule dyes, inorganic nanomaterials, and polymer agents 3 , 4 . Due to the good biodegradability and ease of renal clearance, the organic small-molecule dye type of PTAs represent one of the great success in the field of PTT 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Based on related literatures, the synthesized PTAs can be categorized into three types: organic small-molecule dyes, inorganic nanomaterials, and polymer agents 3 , 4 . Due to the good biodegradability and ease of renal clearance, the organic small-molecule dye type of PTAs represent one of the great success in the field of PTT 4 . Moreover, organic small-molecule PTAs exhibit great potential of easy reproducibility, controlling the preparation, and versatile synthetic modification 5 .…”

Section: Introductionmentioning

confidence: 99%

A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy

Zhang¹,

Hou²,

Kong³

et al. 2022

Theranostics

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Photothermal agents (PTAs) based on organic small-molecule dyes emerge as promising theranostic strategy in imaging and photothermal therapy (PTT). However, hydrophobicity, photodegradation, and low signal-to-noise ratio impede their transformation from bench to bedside. In this study, a novel supramolecular PTT formulation by a stimuli-responsive macrocyclic host is prepared to overcome these obstacles of organic small-molecule PTAs. Methods: Sulfonated azocalix[4]arene (SAC4A) was synthesized as a hypoxia-responsive macrocyclic host. Taking IR780 as an example, the supramolecular nanoformulation IR780@SAC4A was constructed by grinding method, and its solubility, photostability, and photothermal conversion were evaluated. The hypoxia tumor-selective imaging and supramolecular PTT of IR780@SAC4A were further evaluated in vitro and in vivo . Results: IR780@SAC4A is capable of enhancing the solubility, photostability, and photothermal conversion of IR780 significantly, which achieve this supramolecular formulation with good imaging-guided PTT efficacy in vitro and in vivo . Conclusions: This study demonstrates that the supramolecular PTT strategy is a promising cancer theranostic method. Moreover, this supramolecular approach is applicative to construct kinds of supramolecular PTAs, opening a general avenue for extending smart PTT formulations.

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Recent Development of Photothermal Agents (PTAs) Based on Small Organic Molecular Dyes

Cited by 61 publications

References 118 publications

Recent Advance of Nanomaterial-Mediated Tumor Therapies in the Past Five Years

Recent Advance of Nanomaterial-Mediated Tumor Therapies in the Past Five Years

Luminescent nano‐bioprobes based on NIR dye/lanthanide nanoparticle composites

A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy

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