Recent development of biotin conjugation in biological imaging, sensing, and target delivery

Abstract

Despite encouraging results from preliminary studies of anticancer therapies, the lack of tumor specificity remains an important issue in the modern pharmaceutical industry. New findings indicate that biotin or biotin-conjugates could be favorably assimilated by tumor cells that over-express biotin-selective transporters. Furthermore, biotin can form stable complexes with avidin and its bacterial counterpart streptavidin. The strong bridging between avidin and biotin moieties on other molecules is a proven adaptable tool with broad biological applications. Under these circumstances, a biotin moiety is certainly an attractive choice for live-cell imaging, biosensing, and target delivery.

The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis

“…[44] Extensive effort has therefore been made to develop biotin-based platforms for tumor targeting and diagnosis. [45]…”

Development of Protecting Groups for Prodrug-Type Oligonucleotide Medicines

“…Alternatively, by adding soluble functions to the protecting groups, the solubility of oligonucleotides could be improved (Chart 13). As described previously, functional groups such as carbohydrates 44,45) and vitamins 46,47) may improve the cellular …”

“…It has been known that functional groups such as carbohydrates 44,45) and vitamins 46,47) attached to oligonucleotides induce the cellular uptake of oligonucleotides. These functional molecules, attached to the bio-labile protecting groups, can be deprotected in cells, and naked oligonucleotide drugs will then be generated (Chart 7).…”

Trimethyl Lock: A Multifunctional Molecular Tool for Drug Delivery, Cellular Imaging, and Stimuli‐Responsive Materials

“…[7] In compound 67,C PT is attached by ac arbonate linkage at its tertiaryh ydroxyg roup in the Ering to as elf-immolative p-aminobenzyl alcoholu nit bearing the quinoneT ML connected througha na mide at the aminof unction. [103][104][105] In particular, Bvitamins such as folic acid (vitaminB9), [106][107][108][109][110] cobalamin (vitaminB 12), [111][112][113][114] and biotin (vitaminB7) [115] have been shown to be promising candi- Scheme14. Finally,1 ,2-elimination of carbon dioxide leads to the release of CPT and simultaneously restores its fluorescence.…”